Antidepressant-like effect of <i>Cuminum cyminum</i> essential oil on the forced swim and tail suspension tests in male mice

Asadi, Kosar; Maleki, Saeed; Hashjin, Goudarz Sadeghi

doi:10.34172/jsums.2020.27

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…11,26 The γ-terpinene (4.4%), another major component of CREOs, has also shown antidepressant activity in previous experiments. 27,28 Moreover, β-caryophyllene, present in lower proportion in CREOs, has also been found to significantly improve depression-like effects. 29 These findings demonstrate the potential of CREOs as an effective antidepressant.…”

Section: Resultsmentioning

confidence: 99%

“… a Compounds listed in the order of elution from a methyl silicone capillary column. b RIs relative to n-alkanes (C 6 -C 40 ) on the same methyl silicone capillary column. Lawal et al 23 ; Espina et al 24 ; Chutia et al 25 ; Nengguo et al 26 Corse et al 27 Adelani Babarinde et al 28 . …”

Section: Resultsmentioning

confidence: 99%

“…Lawal et al 23 ; Espina et al 24 ; Chutia et al 25 ; Nengguo et al 26 Corse et al 27 Adelani Babarinde et al 28 .…”

Section: Resultsunclassified

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Antidepressant-Like Effect of Essential Oils From Citrus reticulata in Reserpine-Induced Depressive Mouse

Tang¹,

Ai²,

Zhu³

et al. 2022

Natural Product Communications

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Citrus reticulata Blanco has been widely used to cure some diseases such as cold, cough and indigestion. This study is aimed at determining the antidepressant-like effect of C. reticulata essential oils (CREOs) in reserpine-induced depression mice, as well as its possible mechanisms. The compositions of CREOs are firstly analyzed by gas chromatography-mass spectrometry (GC-MS), in which d-limonene is the main component. Moreover, the results from the forced swimming and tail suspension tests show that the inhalation of CREOs can significantly improve the depressive behavior of reserpine-induced depressed mice by reducing the weight of the mice and shortening the immobile time. After sniffing CREOs, the number of normal neurons in the hippocampus of reserpine-induced depressed mice is greatly increased. In addition, CREOs significantly increase the expression level of 5-hydroxytryptamine-1A receptors (5HT-1A), glucocorticoid receptors (GR) and brain-derived neurotrophic factor (BDNF) in the reserpine-treated mice brain tissue. Thus, these results have indicated that CREOs can be potential materials for drug and food development against depression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Antidepressant-Like Effect of Essential Oils From Citrus reticulata in Reserpine-Induced Depressive Mouse

Tang¹,

Ai²,

Zhu³

et al. 2022

Natural Product Communications

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“…Also, GPx acts as a donor to eliminate ROS and inhibiting oxidative damage to neurons and oligodendrocytes (Vodjgani et al 2020). Therefore, antioxidants and anti-in ammatory agents have valuable in the prevention and treatment of the MS (Asadi et al 2020). As seen, coadministration of the CPZ + crocin signi cantly improved adverse effect of the CPZ on serum antioxidants.…”

Section: Discussionmentioning

confidence: 92%

Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice

Tashakori

Hassanpour

Vazir

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Crocin is the main bioactive components of the saffron with neuro generative and protective activity, however, its activity in neurodegenerative disease in not fully elicited. So, the aim of the current study was to determine effects of the crocin on re exive motor behavior, depressive and serum antioxidant activities on cuprizone-induced (CPZ) model of multiple sclerosis (MS) mice. 40 male C57BL/6 mice were randomly assigned into 4 groups. Mice in the control group were treated with normal diet. In group 2, CPZ-induced demyelination was done by chew palate containing 0.2% (w/w) CPZ for 5 weeks. In group 3, normal diet was provided and mice orally received crocin (100 mg/kg) 3 times per week for 5 weeks. In group 4, mice feed CPZ containing diet and orally received crocin (100 mg/kg) three times per for 5 weeks. At the end of the study, re exive motor behavior and depressive tests were done. Also, serum and brain tissue antioxidant activity was determined. According to the data, crocin had positive effects on hind-limb foot angle, hind-and front-limb suspension, surface righting, grip strength and negative geotaxis while CPZ had adverse effect compare to control group (P < 0.05). Co-administration of the CPZ + crocin signi cantly decreased adverse effect of the CPZ on the re exive motor behavior tests (P < 0.05).CPZ signi cantly increased immobility time in the forced swimming test (FST), tail suspension test (TST) and crocin diminished it (P < 0.05). Co-administration of the CPZ + crocin signi cantly decreased adverse effect of the CPZ on immobility time (P < 0.05). CPZ decreased number of cross in open eld test (OFT) and spending time on rotarod and CPZ + crocin signi cantly lessened adverse effect of the CPZ (P < 0.05). CPZ signi cantly increased malondialdehyde (MDA) and decreased glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) and these effects reversed by crocin in brain tissue and serum (P < 0.05). Co-administration of the CPZ + crocin signi cantly improved adverse effect of the CPZ on serum and brain tissue antioxidants (P < 0.05). These results suggested crocin has protective effect against on CPZ-induced MS in mice.

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“…The lowest antioxidant activity and highest neuro-inflammation were seen in people with depression (Moghadam, 2016). Thus, administering antioxidants is useful for treating depression (Asadi et al, 2020). Terpenes are low molecular weight compounds and high lipophilicity permeable to the blood-brain barrier (Ghosh et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Effects of α-pinene Administration During Pregnancy on Depressive-like Behavior Following Delivery in Mice

Elahinia

Hassanpour

Asghari

et al. 2023

IJVM

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Background: Parturition depression is an important physiological problem, and several attempts have been made to ascertain this physiological phenomenon. Natural monoterpenes like α-pinene have numerous beneficial properties, but no studies have been done on their antidepressant potential in postpartum animals. Objectives: This study aimed to determine the effects of prenatal administration of α-pinene on the antidepressant-like behavior of mice following delivery. Methods: Pregnant female mice were randomly assigned into four groups. In the control group, the animals were injected with saline on their 5, 8, 11, 14, and 17 gestation days (GD). In groups 2 to 4, pregnant female mice were injected with α-pinene (0.1, 0.5, and 1 mg/kg, respectively) at GD 5, 8, 11, 14, and 17. On day 2 postpartum, open field test (OFT), rotarod, forced swimming test (FST), and tail suspension test (TST) were used to evaluate the antidepressant activity of α-pinene in mice. Also, serum samples were taken to determine the antioxidant activity. Results: According to the results, α-pinene (0.5 and 1 mg/kg) significantly increased activity in OFT and staying on the rotarod (P≤0.05). Also, α-pinene (0.5 and 1 mg/kg) diminished immobility time (s) in TST and FST on postpartum mice (P≤0.05). α-pinene (0.5 and 1 mg/kg) decreased malondialdehyde while increased glutathione peroxidase, superoxide dismutase, and total antioxidant status levels in postpartum mice as compared with the control group (P≤0.05). Conclusion: It seems that prenatal administration of the α-pinene can alleviate postpartum depression via its antioxidant property in mice.

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Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice

Cited by 6 publications

References 27 publications

Antidepressant-Like Effect of Essential Oils From Citrus reticulata in Reserpine-Induced Depressive Mouse

Antidepressant-Like Effect of Essential Oils From Citrus reticulata in Reserpine-Induced Depressive Mouse

Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice

Effects of α-pinene Administration During Pregnancy on Depressive-like Behavior Following Delivery in Mice

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