Antidepressant-like effect of modafinil in mice: Evidence for the involvement of the dopaminergic neurotransmission

Mahmoudi, Javad; Farhoudi, Mehdi; Talebi, Mahnaz; Sabermarouf, Babak; Sadigh-Eteghad, Saeed

doi:10.1016/j.pharep.2014.11.005

Cited by 25 publications

(7 citation statements)

References 38 publications

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“…In this test, the tip of the tail of each mouse was fixed to a metal hook attached to the centre of a wooden panel (50 cm above the floor) using an adhesive tape and suspended for 6 min. The immobility time during the last 4 min of the test session was calculated (Mahmoudi, Farhoudi, Talebi, Sabermarouf, & Sadigh‐Eteghad, 2015).…”

Section: Methodsmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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This study evaluated the effects of a hydro-alcoholic extract of Melissa officinalis (HAEMO) on anxiety-and depressive-like behaviours, oxidative stress and apoptosis markers in restraint stress-exposed mice. In order to induce a depression-like model, mice were subjected to restraint stress (3 h day −1 for 14 days) and received normal saline or HAEMO (50, 75 and 150 mg kg −1 day −1 ) for 14 days. The administered doses of HAEMO were designated based on the concentration of one of the main phenolic compounds present in the extract, rosmarinic acid (2.55 mg kg −1 at lowest dose); other phytochemical analyses including assays for antioxidant activity, total phenols and flavonoids were also carried out. The behavioural changes in an open field task, elevated plus maze, tail suspension and forced swimming tests were evaluated. Also, malondialdehyde (MDA) levels and enzyme activities of superoxide dismutase and glutathione peroxidase, and total antioxidant capacity were assessed in the prefrontal cortex and hippocampus. Moreover, levels of Bcl-2, Bax and caspase 3 in the brain as well as serum concentration of corticosterone were evaluated. HAEMO (75 and 150 mg kg −1 ) significantly reversed anxiety-and depressive-like behaviours. Also, HAEMO reduced MDA levels, enhanced enzymatic antioxidant activities and restored serum levels of corticosterone. An immunoblotting analysis also demonstrated that HAEMO decreased levels of pro-apoptotic markers and increased anti-apoptotic protein levels in the prefrontal cortex and hippocampus of restraint stress-exposed mice. Our findings suggested that HAEMO reduced inflammation and had anxiolytic and antidepressant effects in mice.

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Section: Methodsmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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“…The tail suspension test (TST) is a behavioral model and one of the most frequently used tasks to evaluate depression-like behavior in mice (Mahmoudi et al, 2015). The apparatus used in the present work consisted of a wooden box (60 ×30 ×40 cm) with a metal hook positioned at the center of the top panel.…”

Section: Methodsmentioning

confidence: 99%

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Salehpour

Farajdokht

Cassano

et al. 2019

Brain Research Bulletin

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This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q10 (CoQ10) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive-like model, mice were subjected to sub-chronic restraint stress for 5 consecutive days. NIR PBM (810 nm laser, 33.3 J/cm2) and/or CoQ10 (500 mg/kg/day, gavage) were administered for five days concomitantly with immobilization. Behavior was evaluated by the forced swim test (FST), tail suspension test (TST), and open field test (OFT). Mitochondrial membrane potential as well as oxidative stress, neuroinflammatory, and markers of apoptosis were evaluated in the prefrontal cortex (PFC) and hippocampus (HIP). The serum levels of pro-inflammatory cytokines, cortisol, and corticosterone were also measured. PBM or CoQ10, or the combination, ameliorated depressive-like behaviors induced by restraint stress as indicated by decreased immobility time in both the FST and TST. PBM and/or CoQ10 treatments decreased lipid peroxidation and enhanced total antioxidant capacity (TAC), GSH levels, GPx and SOD activities in both brain areas. The neuroinflammatory response in the HIP and PFC was suppressed, as indicated by decreased NF-kB, p38, and JNK levels in PBM and/or CoQ10 groups. Intrinsic apoptosis biomarkers, BAX, Bcl-2, cytochrome c release, and caspase-3 and −9, were also significantly down-regulated by both treatments. Furthermore, both treatments decreased the elevated serum levels of cortisol, corticosterone, TNF-, and IL-6 induced by restraint stress. Transcranial NIR PBM and CoQ10 therapies may be effective antidepressant strategies for the prevention of psychopathological and behavioral symptoms induced by stress.

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“…Although the doses of modafinil were certainly different from that used in humans, yet we used these two doses. This was because 50–300 mg/kg of modafinil adequately affects wakefulness and other physiological activities in rodents [4, 24, 25]. …”

Section: Methodsmentioning

confidence: 99%

Disharmony between wake- and respiration-promoting activities: effects of modafinil on ventilatory control in rodents

et al. 2016

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BackgroundModafinil is a wake-promoting drug and has been widely used for daytime sleepiness in patients with narcolepsy and other sleep disorders. A recent case series reported that daily oral modafinil alleviated hypercapnic respiratory failure in patients with COPD. However, the precise action of modafinil on respiration such as hypercapnic and/or hypoxic ventilatory responses remains unclear. The aim of this study is to clarify the effect of modafinil on the ventilatory control.MethodsWe investigated the hypothesis that modafinil enhances resting ventilation as well as the stimulatory ventilatory responses to hypercapnia and hypoxia. We addressed the issue by examining minute ventilation, respiratory rate and volume components using plethysmography, combined with a concurrent EEG monitoring of the level of wakefulness before and after administration of modafinil in two doses of 100 mg/kg and 200 mg/kg in unanesthetized mice. In addition, we monitored the effect of the lower dose of modafinil on mice locomotor activity in a freely moving condition by video-recording.ResultsWakefulness, locomotor activity and variability of the breathing pattern in tidal volume were promoted by both doses of modafinil. Neither dose of modafinil increased the absolute values of resting ventilation or promoted the ventilatory responses to hypercapnia and hypoxia. Rather, higher dose of modafinil slightly suppressed respiratory rate in room air condition.ConclusionsModafinil is conducive to the state of wakefulness but does not augment resting ventilation or the hyperventilatory responses to chemical stimuli in unanesthetized rodents.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-016-0466-9) contains supplementary material, which is available to authorized users.

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Antidepressant-like effect of modafinil in mice: Evidence for the involvement of the dopaminergic neurotransmission

Abstract: Results show that modafinil induced an antidepressant property in TST and this effect apparently was mediated through interaction with the dopaminergic (D2 receptors) system.

Cited by 25 publications

References 38 publications

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Disharmony between wake- and respiration-promoting activities: effects of modafinil on ventilatory control in rodents

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