Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test

Aksöz, Elif; Aksoz, Tolga; Bilge, S. Sırrı; İlkaya, Fatih; Çelik, Süleyman Utku; Diren, B.

doi:10.1016/j.brainres.2008.08.011

Cited by 15 publications

(12 citation statements)

References 23 publications

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“…Dopaminergic agonists also can influence the swimming test by causing an increase in swimming activity (Nikulina et al 1991). Another study on mice by Aksoz et al, also found supporting results by exposing mice to echoplanar MRI (Aksoz et al 2008). Inspired by these two recent studies, we assessed the effect of T1-weighted and echo-planar DWI protocols (as used by Rokni-Yazdi et al) on mood status of human subjects suffering from major depressive disorder.…”

Section: Discussionmentioning

confidence: 62%

“…Rokni-Yazdi et al evaluated the effect of two routine MRI protocols, T1-weighted and echo-planar diffusion weighted imaging (DWI), on a mouse depression model (forced swimming test) and found an antidepressant-like effect with both protocols (Rokni-Yazdi et al 2007). Later, another study on mice by Aksoz et al found supporting results by exposing mice to echo-planar MRI (Aksoz et al 2008).…”

Section: Introductionmentioning

confidence: 76%

“…The majority of these studies are about the effects of rTMS but most recently a few reports indicated positive effects of low field magnetic stimulation (LFMS) or MRI stimulation (Rohan et al 2004;Carlezon et al 2005;Rokni-Yazdi et al 2007;Aksoz et al 2008). Variable outcomes have been reported for rTMS as an antidepressant.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, some studies have investigated the possible role of magnetic resonance imaging-based stimulation or low field magnetic stimulation (LFMS) as a potential antidepressant (Rohan et al 2004;Carlezon et al 2005;Rokni-Yazdi et al 2007;Aksoz et al 2008). Rohan et al reported mood improvement in human subjects with bipolar disorder using echo planar magnetic resonance spectroscopy imaging (MRSI) (Rohan et al 2004) and Carlezon et al reported antidepressant effects of LFMS in rats (Carlezon et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Despite these findings in animal models (Carlezon et al 2005;Rokni-Yazdi et al 2007;Aksoz et al 2008), no human studies are available on subjects with major depressive disorder. In this study, for the first time, we designed a clinical trial to evaluate the possible antidepressant effects of two routine MRI sequences (T1 and DWI) on patients with major depressive disorder.…”

Section: Introductionmentioning

confidence: 99%

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Antidepressant effects of magnetic resonance imaging—based stimulation on major depressive disorder: a double-blind randomized clinical trial

Vaziri-Bozorg

Ghasemi-Esfe

Khalilzadeh

et al. 2011

Brain Imaging and Behavior

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Antidepressant effects of magnetic resonance imaging (MRI) based stimulation have been reported in animal studies, but no human studies are available on subjects with major depressive disorder. Here, the efficacy of two diagnostic MRI protocols (echo-planar diffusion-weighted imaging (DWI) and T1-weighted imaging) was assessed in patients with major depressive disorder. In this double-blind randomized clinical trial, 51 patients with clinically proven major depressive disorder were randomly enrolled into three equal groups. All patients were receiving a selective serotonin reuptake inhibitor as the only antidepressant treatment. The first group received echo-planar DW stimulation (DWI group), the second group received T1-weighted stimulation (T1 group), and the third group experienced a similar condition without receiving any magnetic stimulation (sham group). The Hamilton rating scale for depression (HAMD24) and Beck depression inventory (BDI) were used to assess the effect of MR stimulation on depressive symptoms. In comparison to baseline, mean HAMD24 and BDI scores significantly (p < 0.001) decreased in the DWI (by 35% and 39%) and T1 (by 38% and 39%) groups 2 weeks after MR stimulation. In the sham group, reduction in HAMD24 (19%, p = 0.04) and BDI score (15%, p = 0.07) were lower than the MR stimulation groups. Two weeks after the MR experiments, changes in mean HAMD24 score and BDI score were significantly (p < 0.05) higher in subjects treated with MR stimulation (DWI or T1) vs. sham group. In conclusion, this study demonstrated the antidepressant effects of DWI and T1 MRI protocols. Our results may point to usefulness of MR stimulation for clinical use in patients with major depressive disorder.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 76%