Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Qiu, Fengmei; Zhang, Xiaoming; Mao, Qing-Qiu; Huang, Zhen

doi:10.1016/j.neulet.2013.02.029

Cited by 46 publications

(41 citation statements)

References 25 publications

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“…[18][19][20] "Body weight measurement," "sucrose preference test," and "open field test" were selected for assessing behaviors. We used a Student's ttest to analyze the difference in the mean values of behavioral assessment between the control and CS groups.…”

Section: Animalsmentioning

confidence: 99%

High-Resolution Magic-Angle Spinning-<sup>1</sup>H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms

Akimoto

Oshima

Ohara

et al. 2017

Biological & Pharmaceutical Bulletin

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Depressive disorders cause large socioeconomic effects influencing not only the patients themselves but also their family and broader community as well. To better understand the physiologic factors underlying depression, in this study, we performed metabolomics analysis, an omics technique that comprehensively analyzes small molecule metabolites in biological samples. Specifically, we utilized high-resolution magic-angle spinning-1 H-NMR (HRMAS-1 H-NMR) spectroscopy to comprehensively analyze the changes in metabolites in the hippocampal tissue of rats exposed to chronic stress (CS) via multi-step principal component analysis (multi-step PCA). The rats subjected to CS exhibited obvious depression-like behaviors. High correlations were observed between the first principal component (PC1) score in the score plot obtained using multi-step PCA and measurements from depression-like behavioral testing (body weight, sucrose preference test, and open field test). Alanine, glutamate, glutamine, and aspartate levels in the hippocampal tissue were significantly lower, whereas N-acetylaspartate, myo-inositol, and creatine were significantly higher in the CS group compared to the control (non-CS) group. As alanine, glutamate, and glutamine are known to be involved in energy metabolism, especially in the tricarboxylic acid cycle, chronic exogenous stress may have induced abnormalities in energy metabolism in the brains of the rats. The results suggest that N-acetylaspartate and creatine levels may have increased in order to complement the loss of energy-producing activity resulting from the development of the depression-like disorder. Multi-step PCA therefore allowed an exploration of the degree of depression-like symptoms as represented by changes in intrinsic metabolites.

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Section: Animalsmentioning

confidence: 99%

High-Resolution Magic-Angle Spinning-<sup>1</sup>H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms

Akimoto

Oshima

Ohara

et al. 2017

Biological & Pharmaceutical Bulletin

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“…The terpenoid paeoniflorin was found to inhibit L-type Ca 2+ channels [158] and Na + channels, but the physiological significance of the latter observation is questionable as the IC 50 is 271 μM [159]. The compound exhibited neuroprotective activity via inhibition of microglia [160] and MAPKs/NF-κB-mediated inflammatory responses [161], and antidepressant-like effects [162]. The terpenoid β-eudesmol was found to activate TRPA1 channels [163].…”

Section: Other Ion Channelsmentioning

confidence: 99%

A pharmacological basis of herbal medicines for epilepsy

Sucher¹,

Carles²

2015

Epilepsy & Behavior

125

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“…Some animal experiments related to depression have shown paeoniflorin to significantly shorten swimming immobility time and tail suspension of mice, and blepharoptosis induced by reserpine antagonist (Qiu et al, 2013b;Cui, 2009). It also markedly ameliorates depressive-like behaviors in interferon-α (IFN-α)-induced mice, ovariectomized rats under stress, and chronic unpredictable stress (CUS) induced rats (Qiu et al, 2013a;Huang et al, 2015;Li et al, 2017). This suggests that paeoniflorin may be useful in the prevention of depression.…”

Section: Introductionmentioning

confidence: 99%

“…Paeoniflorin is a major active ingredient in the root of Paeonia lactiflora Pall. (Ranunculaceae), a Chinese medicinal herb widely used for treating depression-like disorders in many prescriptions of traditional Chinese medicine, including "Danggui Shaoyao San" and "Xiaoyao powder" (Qiu et al, 2013a). In many studies, paeoniflorin is found to be effective in treating several types of animal models of depression.…”

Section: Introductionmentioning

confidence: 99%

Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin

Chen

Qiu

Zhang

et al. 2019

J. Integr. Neurosci.

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J o u r n a l o f I n t e g r a t i v e N e u r o s c i e n c eThis is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/) Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study, the effects of paeoniflorin on neurogenesis in the hippocampus dentate gyrus and potential mechanism of action are further investigated in chronic unpredictable stress-induced rat. Results suggest that paeoniflorin markedly increased both sucrose consumption and the number of 5-bromo-2-deoxyuridinepositive cells in the dentate gyrus of chronic unpredictable stress-induced rats, and the ratio of co-expressed 5-bromo-2-deoxyuridine and glial fibrillary acidic protein-positive cells, but exerted no significant effect on the ratio of coexpressed 5-bromo-2-deoxyuridine and neuronal nucleipositive cells. Compared with the vehicle group, a significant increase was detected in the number of brainderived neurotrophic factor-positive cells and the expression of brain-derived neurotrophic factor mRNA in the hippocampus of the paeoniflorin-treated group. According to the results, paeoniflorin promoted neural stem cell proliferation, their differentiation into astrocytes, and neurogenesis in the hippocampal dentate gyrus of chronic unpredictable stress-induced rats. Apart from enhancing the protein expression and gene transcription of brainderived neurotrophic factor, it also activated the expression of tropomyosin receptor kinase B (a high-affinity receptor of brain-derived neurotrophic factor). This suggests that paeoniflorin might promote neurogenesis in the hippocampus dentate gyrus of chronic unpredictable stressinduced rats and act as an antidepressant by regulating the brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling pathway.

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Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Cited by 46 publications

References 25 publications

High-Resolution Magic-Angle Spinning-<sup>1</sup>H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms

High-Resolution Magic-Angle Spinning-<sup>1</sup>H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms

A pharmacological basis of herbal medicines for epilepsy

Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin

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