Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms

Abstract

Depression is a mental disorder characterized by low mood, lack of motivation, negative cognitive outlook, and sleep problems. Suicide may occur in severe cases, although suicidal thoughts are not seen in all cases. Globally, an estimated 350 million individuals grapple with depression, as reported by the World Health Organization. At present, drug and psychological treatments are the main treatments, but they produce insufficient responses in many patients and fail to work at all in many others. Consequently, treating depression has long been an important topic in society. Given the escalating prevalence of depression, a comprehensive strategy for managing its symptoms and impacts has garnered significant attention. In this context, nutritional psychiatry emerges as a promising avenue. Extensive research has underscored the potential benefits of a well-rounded diet rich in fruits, vegetables, fish, and meat in alleviating depressive symptoms. However, the intricate mechanisms linking dietary interventions to brain function alterations remain largely unexplored. This review delves into the intricate relationship between dietary patterns and depression, while exploring the plausible mechanisms underlying the impact of dietary interventions on depression management. As we endeavor to unveil the pathways through which nutrition influences mental well-being, a holistic perspective that encompasses multidisciplinary strategies gains prominence, potentially reshaping how we approach and address depression.

Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review

“…It is associated with somatic diseases such as heart disease, Nutrients 2024, 16, 1665 2 of 18 stroke, diabetes mellitus, asthma, cancer, arthritis, and osteoporosis and is bridged by inflammation, which is a risk factor for mood disorders [12,13]. Immune processes and also neurotransmitters are influenced by diet, which can produce similar effects to antidepressants [14]. Nutrition interventions, assuming a balanced diet and also being rich in appropriate active ingredients, are an attractive option among depressed patients struggling additionally with obesity, whose eating habits are usually incorrect.…”

Negative Association of Lignan and Phytosterol Intake with Stress Perception during the COVID-19 Pandemic—A Polish Study on Young Adults

“…They exert a broad spectrum of biological activities that may prevent or support the treatment of many diseases [22], and the evidence from observational studies suggests that higher intakes of polyphenols may be inversely associated with the risk of cognitive disorders [24] and other chronic diseases, like cardiovascular diseases [25] and hypertension [26]. Lignans and phytosterols can have an antidepressant effect related to increasing serotonin levels, reducing cortisol levels, suppressing neuroinflammatory reactions, including in microglia, and inhibiting stressinduced damage to intestinal barrier integrity [27][28][29]. A diet rich in these phytochemicals can enhance stress-related oxidative damage, promote mental health, and help reduce the risk of developing mental illness.…”