Antidepressant-like effects of selegiline in the forced swim test

Shimazu, Seiichiro; Minami, Anzu; Kusumoto, Haruko; Yoneda, Fumio

doi:10.1016/j.euroneuro.2005.02.003

Cited by 39 publications

(26 citation statements)

References 33 publications

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“…Other studies have shown that the majority of antidepressants also reduce the immobility time in the forced swimming test (8,11), as does analeptic amine (12). It has also been reported that antidepressants do not change spontaneous momentum (11), whereas analeptic amine increases spontaneous momentum (12). Because 1a(OH)D3 did not affect the spontaneous momentum in the open field test in the present study, our results suggest that 1a(OH) D3 may exhibit antidepressive effects.…”

Section: Locomotor Activity Laboratory Findings For the Open Field Tesupporting

confidence: 39%

“…In this study, we found that 1a,25(OH)2D3 decreased the immobility time of mice in the forced swimming test. Other studies have shown that the majority of antidepressants also reduce the immobility time in the forced swimming test (8,11), as does analeptic amine (12). It has also been reported that antidepressants do not change spontaneous momentum (11), whereas analeptic amine increases spontaneous momentum (12).…”

Section: Locomotor Activity Laboratory Findings For the Open Field Tementioning

confidence: 94%

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Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Kawaura

Kitamura

Tanida³

et al. 2017

J Nutr Sci Vitaminol

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SummaryWe examined the effect of 1a-hydroxyvitamin D3 [1a(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 mg/kg of 1a(OH)D3 reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 mg/kg), 1a(OH)D3 had no effect on locomotor activity, compared with controls. These results suggest that 1a(OH)D3 may have antidepressant-like activity. Key Words 1a-hydroxyvitamin D3, forced swimming test, glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor Depression is a global problem associated with multiple social and health issues (1). Medical treatment of depression is mostly unsatisfactory, as exemplified by a recent re-analysis demonstrating the ineffectiveness of a highly promoted class of drugs used for treating depression (2). A more effective drug not belonging to the antidepressant class is expected in the near future. The relationship between depression and vitamin D has become a topic of research interest in recent years.The likelihood of depression in subjects with vitamin D deficiency is significantly higher than in subjects who are vitamin D sufficient (3). Mean 25-hydroxyvitamin D levels were shown to be markedly lower in patients with minor and major depression than in healthy subjects (4). A clear clinical link between vitamin D and depression has not been established, however. Lansdowne and Provost investigated healthy subjects in the winter, when vitamin D is at low concentrations, and confirmed that mood could be improved when a healthy person is given vitamin D at 400 or 800 IU during winter (5). Furthermore, it was reported that a single dose of 300,000 IU of vitamin D decreases the severity of depression in elderly patients who are taking antidepressants (6). The combination of vitamin D and fluoxetine was shown to be significantly more effective for patients with major depressive disorder than fluoxetine alone (7). To date, however, no reports have been published demonstrating the effect of administration of vitamin D alone on patients with major depressive disorder. Therefore, it is necessary to examine the effect of vitamin D on the depressive state. Almost all antidepressant drugs reduce the immobility time of rats in the forced swimming test (8). Following administration, 1a-hydroxyvitamin D3 [1a(OH)D3] is metabolized in the liver to 1a,25-dihydroxyvitamin D3 [1a,25(OH)2D3], which shows an effect through 1a,25(OH)2D3 receptor (vitamin D3 receptor) distributed over the body (9) including the central nervous system (10). Therefore, we examined the effect of 1a(OH)D3 using the depression model described by Porsolt et al. (8). Materials and MethodsA total of 40 male 5-wk-old ICR mice were obtained from Charlies River Laboratory Co., Ltd. (Kyoto, Japan) 1 wk before the experiment. The mice were housed in plastic cages (3 mice/cage) with sterilized wood chips as bedding in an air-conditioned room maintained at 2362˚C and 5565% humidity with a 12-h alternating light and dark cycle. The mice were fed a commercial...

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Section: Locomotor Activity Laboratory Findings For the Open Field Tesupporting

confidence: 39%

Section: Locomotor Activity Laboratory Findings For the Open Field Tementioning

confidence: 94%

Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Kawaura

Kitamura

Tanida³

et al. 2017

J Nutr Sci Vitaminol

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“…These results are consistent with earlier reports (9). To investigate the possibility that the changes in immobility were associated with changes in locomotor activity, we examined the effect of selegiline on locomotor activity in rats.…”

Section: Discussionsupporting

confidence: 80%

Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone–Treated Rats

et al. 2008

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Abstract. In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D 3 -receptor antagonist in normal and ACTHtreated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D 3 receptor.

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“…(3) These results are similar to those observed in rats (Millan et al 1997) and mice (Lucki et al 2001), thereby allowing comparison of the antidepressant effects in the different species. (4) The atypical antipsychotic clozapine did not affect forced swim activity, whereas the prototypical psychostimulant methamphetamine increased latency to immobility in a dose-related manner, in agreement with the effects observed in rats (Shimazoe et al 1987) and mice (Shimazu et al 2005). 5) The newly developed NK 1 receptor antagonists (Kramer et al 1998) exhibit antidepressant-like activity.…”

Section: Discussionsupporting

confidence: 74%

The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants

Wicke¹,

Rex

Jongen-Rêlo³

et al. 2007

Psychopharmacology

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We demonstrate the suitability of a modified procedure of the FST for a nonmurid species: the guinea pig. Known antidepressants showed similar effects as in rats and mice. It is interesting to note that the NK(1) antagonist L-733,060 increased forced swimming, suggesting its antidepressant potential. Thus, the guinea pig FST allows the study of antidepressant activity also in NK(1) antagonists that cannot be studied appropriately in murids.

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Antidepressant-like effects of selegiline in the forced swim test

Cited by 39 publications

References 33 publications

Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone–Treated Rats

The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants

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Antidepressant-like effects of selegiline in the forced swim test

Cited by 39 publications

References 33 publications

Antidepressant-Like Effect of 1&alpha;-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Antidepressant-Like Effect of 1&alpha;-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone–Treated Rats

The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants

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Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test

Antidepressant-Like Effect of 1α-Hydroxyvitamin D<sub>3</sub> on Mice in the Forced Swimming Test