Antidepressant-like effects of transcorneal electrical stimulation in rat models

Yu, Wing Shan; Tse, Alex Wing Cheung; Guan, Li; Chiu, Jennifer Lok Yu; Tan, Shawn Zheng Kai; Khairuddin, Sharafuddin; Agadagba, Stephen Kugbere; Lo, Amy Cheuk Yin; Fung, Man-Lung; Chan, Yuen-Yan; Chan, Leanne Lai Hang; Lim, Lee Wei

doi:10.1016/j.brs.2022.05.018

Cited by 15 publications

(27 citation statements)

References 106 publications

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“…The stimulation parameters of 100/200 μA, 20 Hz, 1 ms/phase, 1 h/day, 3 consecutive weeks used in this study were based on a previous study that reported optimal TES parameters in rescuing retinal ganglion cells in rats 40 . In particular, TES at 200 μA was shown to enhance neuroprotection through neuroplasticity‐ and apoptosis‐related mechanisms in the retina and the hippocampus of rodent models 29,43 . We found an enhanced performance in the MWM probe test in aged mice stimulated at either 100 or 200 μA, indicating that both amplitudes could improve spatial memory retrieval in our aged model.…”

Section: Discussionmentioning

confidence: 78%

“…The adverse effects observed in the kindled model were likely triggered by the higher stimulation intensity ranging from 6 to 19 mA, which can cause tissue damage. This highlights a double‐edged sword effect of TES, as it can generate different outcomes depending on the stimulation strength 28,29,77 . Therefore, optimal stimulation parameters need to be established for efficacy 29,45,50,78 …”

Section: Discussionmentioning

confidence: 99%

“…Sham groups were similarly treated but with the stimulator turned off. The stimulation parameters were determined based on previous studies that demonstrated the neuroprotective effects of TES in animal models 29,40,43 . Control groups were also subjected to 1 h of isoflurane anesthesia on stimulation days to eliminate confounding effects of isoflurane exposure on cognitive performance.…”

Section: Methodsmentioning

confidence: 99%

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Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Aquili

Wong

et al. 2022

Annals of the New York Academy of Sciences

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Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse models, in aged mice and in the 5XFAD model of Alzheimer's disease.After 3 weeks of TES treatment, mice were subjected to Y-maze and Morris water maze tests to assess hippocampal-dependent learning and memory. Immunostaining of the hippocampus of 5XFAD mice was also performed to examine the effects of TES on amyloid plaque pathology. The results showed that TES improved the performance of both aged and 5XFAD mice in memory tests. TES also reduced hippocampal plaque deposition in male, but not female, 5XFAD mice. Moreover, TES significantly reversed the downregulated level of postsynaptic protein 95 in the hippocampus of male 5XFAD mice, suggesting the effects of TES involve a postsynaptic mechanism. Overall, these findings support further investigation of TES as a potential treatment for cognitive dysfunction and mechanistic studies of TES effects in other dementia models.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Aquili

Wong

et al. 2022

Annals of the New York Academy of Sciences

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Section: Limitations and Future Perspectivementioning

confidence: 99%

“…Recent progress in nanotechnology [ 84 ] and neuromodulation techniques [ 85 , 86 , 87 , 88 , 89 ] could pave the way for revolutionizing the development of compounds to tackle dementia. In particular, one could combine HE treatment with an invasive/non-invasive brain stimulation approach to enhance the therapeutic potential of memory function in AD patients [ 85 , 86 , 87 , 88 , 89 ]. In this respect, the development of nanotherapeutics with multi-functionalities has considerable potential to bridge the gap between the challenges associated with current therapeutics and their clinical application as treatments for AD.…”

Section: Limitations and Future Perspectivementioning

confidence: 99%

The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

Yanshree

Fung

et al. 2022

Cells

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Alzheimer’s disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder. Therefore, researchers have been investigating Hericium erinaceus, or the monkey head mushroom, an edible medicinal mushroom, as a possible treatment for AD. In this narrative review, we evaluated six preclinical and three clinical studies of the therapeutic effects of Hericium erinaceus on AD. Preclinical trials have successfully demonstrated that extracts and bioactive compounds of Hericium erinaceus have potential beneficial effects in ameliorating cognitive functioning and behavioral deficits in animal models of AD. A limited number of clinical studies have been conducted and several clinical trials are ongoing, which have thus far shown analogous outcomes to the preclinical studies. Nonetheless, future research on Hericium erinaceus needs to focus on elucidating the specific neuroprotective mechanisms and the target sites in AD. Additionally, standardized treatment parameters and universal regulatory systems need to be established to further ensure treatment safety and efficacy. In conclusion, Hericium erinaceus has therapeutic potential and may facilitate memory enhancement in patients with AD.

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Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Cui,

Wu,

Zhang

et al. 2024

Advanced Science

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With the integration of bioelectronics and materials science, implantable self‐powered systems for electrical stimulation medical devices have emerged as an innovative therapeutic approach, garnering significant attention in medical research. These devices achieve self‐powering through integrated energy conversion modules, such as triboelectric nanogenerators (TENGs) and piezoelectric nanogenerators (PENGs), significantly enhancing the portability and long‐term efficacy of therapeutic equipment. This review delves into the design strategies and clinical applications of implantable self‐powered systems, encompassing the design and optimization of energy harvesting modules, the selection and fabrication of adaptable electrode materials, innovations in systematic design strategies, and the extensive utilization of implantable self‐powered systems in biological therapies, including the treatment of neurological disorders, tissue regeneration engineering, drug delivery, and tumor therapy. Through a comprehensive analysis of the latest research progress, technical challenges, and future directions in these areas, this paper aims to provide valuable insights and inspiration for further research and clinical applications of implantable self‐powered systems.

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Antidepressant-like effects of transcorneal electrical stimulation in rat models

Cited by 15 publications

References 106 publications

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

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