Antidepressant Medication Adherence

Tamburrino, Marijo; Nagel, Rollin; Chahal, Mangeet K.; Lynch, Denis J.

doi:10.4088/pcc.08m00694

Cited by 39 publications

(14 citation statements)

References 44 publications

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“…This could reflect the fact that younger patients have had less experience with the disease and its medications. It is also possible that the more common side effects of weight gain and impaired sexual function are of particular concern to younger patients 20. On the other hand, the high adherence scores among patients who have more follow-up visits with a psychiatrist per year could be related to the effect of physician–patient contact and the patient’s satisfaction 38…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the factors associated with adherence to antidepressant medication,6,9,19,20 and the results from a recent review show that factors associated with adherence to antidepressants and sociodemographic indictors are inconsistent 6. Certain factors have been identified as predictors of adherence to antidepressant medication, including sociodemographic factors, educational level, clinical factors (eg, severity of symptoms), quality of life, and side effects 6,9.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study

Jumah¹,

Hassali²,

Qhatani³

et al. 2014

NDT

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BackgroundSeveral studies have investigated the factors associated with adherence to antidepressants, with inconsistent conclusions. However, no similar study has investigated this issue among patients diagnosed with major depressive disorder in Saudi Arabia. The aim of this study is to explore patients’ adherence to antidepressant medications, and the factors associated with adherence.MethodsA non-experimental cross-sectional design was used to measure adherence to antidepressants among major depressive disorder patients, and the factors associated with adherence. The patients were recruited from the outpatient clinic at the Al-Amal Complex for Mental Health in Riyadh, Saudi Arabia, between August 2013 and January 2014. Eligible participants met with one of the research coordinators for assessment of their adherence. Adherence was investigated indirectly by use of the Morisky Medication Adherence Scale, and patients’ beliefs were assessed through the Beliefs about Medicine Questionnaire. Information about the severity of their depression, demographics, and other study variables were collected.ResultsA total of 403 patients met the inclusion criteria and participated in the study. Of those, 203 (50.37%) were females, while the remaining 200 (49.6%) were males. There was an average age of 39 years (standard deviation, ±11 years). Half of the patients (52.9%) reported low adherence to their antidepressant medication, with statistically significant differences between the low adherence and high adherence scores relating to sex, age, and duration of illness.ConclusionLow medication adherence is a common problem among major depressive disorder patients in Saudi Arabia. Medication-taking behavior among depressed patients is influenced by several factors, mainly patients’ beliefs regarding antidepressants. This study has improved the understanding of the factors associated with adherence to antidepressants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study

Jumah¹,

Hassali²,

Qhatani³

et al. 2014

NDT

View full text Add to dashboard Cite

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“…4 Reasons for nonadherence to antidepressant therapy include adverse effects or anxiety about adverse effects, poor patient-physician communication, carelessness with taking medication, poor social support, low efficacy, and lack of knowledge. 5,6,7,8 Long-term adherence to medications for bipolar disorder, such as lithium, ranges from 20 to 66%. 9 Low adherence to behavioral health medications is a concern due to increased risk of relapse, suicide attempts, and hospitalizations leading to increased morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Medication adherence challenges among patients experiencing homelessness in a behavioral health clinic

Coe

Moczygemba

Gatewood

et al. 2015

Research in Social and Administrative Pharmacy

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Background Behavioral health medication nonadherence is associated with poor health outcomes and increased healthcare costs. Little is known about reasons for nonadherence with behavioral health medications among homeless people. Objectives To identify reasons for medication nonadherence including the sociodemographic, health-related factors, and behavioral health conditions associated with medication nonadherence among behavioral health patients served by a Health Care for the Homeless center (HCH) in Virginia. Methods The study sample was selected from an existing database that included sociodemographic, health-related information, and medication-related problems identified during a pharmacist-provided medication review conducted during October 2008–September 2009. Patients experiencing or at risk of homelessness who were ≥ 18 years old with at least one behavioral health condition who had a medication review were eligible for the study. A qualitative content analysis of the pharmacist documentation describing the patient’s reason(s) for medication nonadherence was conducted. The Behavioral Model for Vulnerable Populations was the theoretical framework. The outcome variable was self-reported medication nonadherence. Descriptive and multivariate (logistic regression) statistics were used. Results A total of 426 individuals met study criteria. The mean age was 44.7 ± 10.2 years. Most patients were African-American (60.5%) and female (51.6%). The content analysis identified patient-related factors (74.8%), therapy-related factors (11.8%), and social or economic factors (8.8%) as the most common reasons for patients’ medication nonadherence. Patients with post-traumatic stress disorder (PTSD) (adjusted odds ratio: 0.4; 95% CI: 0.19–0.87) were less likely to have a medication adherence problem identified during the medication review. Conclusions The content analysis identified patient-related factors as the most common reason for nonadherence with behavioral health medications. In the quantitative analysis, patients with a PTSD diagnosis were less likely to have nonadherence identified which may be related to their reluctance to self-report nonadherence and their diagnosis, which warrants further study.

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“…In one study reported that adherent subjects had a higher level of satisfaction with their physicians, with 87% indicating "excellent" or "very good," while only 60% of the nonadherent subjects indicated this level of satisfaction [21,22]. Unawareness of nature of depression disorder and adherence to treatment regimen has significantly influenced (p=0.49, t-test) mean drug attitude inventory scores in our study.…”

Section: Discussionmentioning

confidence: 59%

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

M¹

2015

J Depress Anxiety

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Introduction: Depression is a term used to describe a health problem in which mood pattern will be affected. Clinical depression is more severe and the symptoms can continue for weeks, months, and even years in some cases if it is not treated and it does interfere with our ability to function and it also can leads to suicide at its worst. Although clinical guidelines recommend antidepressants be continued for at least 6 months after symptom remission, approximately one third of patients discontinue antidepressants within the first month of treatment, and 44% discontinue them by the third month of treatment. Adherence to antidepressants is a stimulating problem in the management of patients with depression. Various factors such as nature and duration of therapy, disease characteristics, medication side-effects, cost of treatment, characteristics of health service facilities, the relation among the physician and patient, patient characteristics such as socioeconomic factors, patient's perspective about the illness and treatment have been reported to influence adherence.

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Antidepressant Medication Adherence

Cited by 39 publications

References 44 publications

Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study

Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study

Medication adherence challenges among patients experiencing homelessness in a behavioral health clinic

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

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