Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence

Suicidality: prevention, detection and intervention

“…25 The FDA black box warning in 2004 cautioned prescribers about an increase in suicidal thinking and behaviour (although not successful suicides) in young people prescribed antidepressants. However subsequently several studies [26][27][28] have shown an inverse relation between successful suicide and antidepressant prescribing in this age group.…”

S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α2-Adrenoceptor Antagonist and Potential Antidepressant: I. A Mechanistic Characterization

“…S32212 recognized all three isoforms of ␣ 2 -AR, blockade of which should positively affect mood, cognition, and other functions (below and Dekeyne et al, 2012). Conversely, its affinity was low for ␣ 1 -ARs, the blockade of which (most importantly of the ␣ 1A -subtype) induces sedation, orthostatic hypotension, and cardiovascular-autonomic side effects (Szegedi and Schwertfeger, 2005;Millan, 2006;Sartorius et al, 2007). This is an important distinction to the high potencies of several antidepressants at ␣ 1A -ARs, notably tricyclics such as desipramine and the tetracyclic agents mirtazapine and mianserin (Anttila and Leinonen, 2001;Szegedi and Schwertfeger, 2005;Millan 2006).…”

“…This is an important distinction to the high potencies of several antidepressants at ␣ 1A -ARs, notably tricyclics such as desipramine and the tetracyclic agents mirtazapine and mianserin (Anttila and Leinonen, 2001;Szegedi and Schwertfeger, 2005;Millan 2006). Sedation, somnolence, weight gain, and compromised cognition are risks associated with the blockade of histamine H 1 receptors, as illustrated by mirtazapine, the 5-HT 2C antagonist/5-HT reuptake inhibitors, trazodone, and tricyclics such as amitriptyline (Anttila and Leinonen, 2001;Szegedi and Schwertfeger, 2005;Millan, 2006;Sartorius et al, 2007). It is thus important that S32212 had low affinity for H 1 receptors.…”

“…Major depression is a common, serious, and heterogeneous disorder for which current treatment is inadequate (Sartorius et al, 2007;Wittchen et al, 2011). In the search for more effective drugs, recent years have witnessed a focus on drugs interacting selectively with one specific target.…”

Mood Stabilizer Therapy and Pravastatin: Higher Risk for Adverse Skin Reactions?

“…Polymedication was indicated at her hospitalisation, comprising among other drugs a combination of an antidepressant with an antipsychotic agent, in accordance with some recent guideline (9).…”