Antidepressant Response and Stress Resilience Are Promoted by CART Peptides in GABAergic Neurons of the Anterior Cingulate Cortex

Funayama, Yuki; Li, Haiyan; Ishimori, Erina; Kawatake-Kuno, Ayako; Inaba, Hiromichi; Yamagata, Hirotaka; Seki, Tomoe; Nakagawa, Shin; Watanabe, Yoshifumi; Murai, Toshiya; Oishi, Naoya; Uchida, Shinichi

doi:10.1016/j.bpsgos.2021.12.009

Cited by 12 publications

(14 citation statements)

References 68 publications

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“…Following these criteria, we generated a list of 10 candidates ( Table 1 ). The most striking pattern was the expression of CARTPT (Cocaine- And Amphetamine-Regulated Transcript Protein), a neuropeptide implicated in feeding, reward and stress (Carpenter et al, 2020; Funayama et al, 2022; Kristensen et al, 1998; Lee et al, 2022). We found CARTPT highly expressed in the MeA and in a pattern resembling the distribution of Dbx1 -lineage cells ( Figure 5A , B ), and complementary to the distribution of Foxp2+ cells ( Figure 5C ).…”

Section: Resultsmentioning

confidence: 99%

Section: Mea Foxp2+ and Dbx1-lineage Cells Express Different Cohorts ...mentioning

confidence: 99%

“…Feeding, Cocaine/Reward-seeking, Stress resiliency, Social dominance and Aggression (Carpenter et al, 2020;Funayama et al, 2022;Kristensen et al, 1998;Lee et al, 2022) Table 1: List of neuropeptide and receptor candidate genes expressed in the MeA and previously implicated in social or other behaviors.…”

Section: Npy1rmentioning

confidence: 99%

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Molecular diversity and connectivity of accessory olfactory system neurons

Prakash

Matos

Sebaoui

et al. 2022

Preprint

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Olfaction is the primary sensory modality by which most vertebrate species interpret environmental cues for appropriate behavioral outputs. The olfactory system is subdivided into main (MOS) and accessory (AOS) components which process volatile and non-volatile cues. While much is known regarding the molecular diversity of neurons that comprise the MOS, less is known about the AOS. Here, focusing on the AOS which is largely comprised of the peripheral vomeronasal organ (VNO), the accessory olfactory bulb (AOB) and the medial subnucleus of the amygdala (MeA), we studied the molecular diversity and neuronal subtype connectivity of this interconnected circuit. We show that populations of neurons of the AOS can be molecularly subdivided based on their current or prior expression of the transcription factorsFoxp2orDbx1. We show that the majority of AOB neurons that project directly to the MeA are of theFoxp2-lineage. Using single cell patch clamp electrophysiology, we further reveal that in addition to sex-specific differences across lineage, the relative contributions of excitatory and inhibitory inputs to MeAFoxp2-lineage neurons differ between sexes. Together, this work uncovers a novel molecular diversity of AOS neurons and lineage- and sex-differences in patterns of connectivity.

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Section: Resultsmentioning

confidence: 99%

Section: Mea Foxp2+ and Dbx1-lineage Cells Express Different Cohorts ...mentioning

confidence: 99%

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Molecular diversity and connectivity of accessory olfactory system neurons

Prakash

Matos

Sebaoui

et al. 2022

Preprint

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“…For example, outbred NIH-Swiss strain and inbred C57BL/6JRj strains showed decreased immobility following administration of TCAs, SSRIs, and dopamine reuptake inhibitors, whereas outbred NMRI and inbred DBA/2 strains were selectively sensitive to SSRIs (Ripoll et al, 2003). Similar differences in inbred strains are commonly observed in FST (Jacobson and Cryan, 2007;Funayama et al, 2022). C57BL/6J strain shows the greatest baseline immobility which allows for better establishment of the dose-response curve 10.3389/fnbeh.2022.931964 (Ripoll et al, 2003;Crowley et al, 2005).…”

Section: Behavioural Despair Fatigue and Helplessnessmentioning

confidence: 92%

Encore: Behavioural animal models of stress, depression and mood disorders

Petković

Chaudhury

2022

Front. Behav. Neurosci.

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Animal studies over the past two decades have led to extensive advances in our understanding of pathogenesis of depressive and mood disorders. Among these, rodent behavioural models proved to be of highest informative value. Here, we present a comprehensive overview of the most popular behavioural models with respect to physiological, circuit, and molecular biological correlates. Behavioural stress paradigms and behavioural tests are assessed in terms of outcomes, strengths, weaknesses, and translational value, especially in the domain of pharmacological studies.

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“…Single strains of rodents are often used to establish an animal model of human diseases, yet the conclusions from such experiments are predicated on the assumption that they can be generalized to humans, which presupposes that they can at least be generalized to other inbred mouse strains (12). Different inbred strains of mice exhibit substantial differences in anxiety, stress reactivity, and drug responsiveness, and they can thus be used as animal models for investigating the influence of GxE factors on brain functions and behaviors (13)(14)(15)(16)(17)(18)(19). Among inbred mouse strains, we and others have demonstrated that the C57BL/6J (B6) strain shows stress habituation (i.e., a reduced stress response) to repeated stress exposure, whereas the BALB/c (BALB) strain lacks stress habituation to the same stressor and eventually exhibits depression-like behaviors (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency

Inaba

Kawatake-Kuno

et al. 2023

Sci. Adv.

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Chronic stress increases the risk of developing psychiatric disorders, including mood and anxiety disorders. Although behavioral responses to repeated stress vary across individuals, the underlying mechanisms remain unclear. Here, we perform a genome-wide transcriptome analysis of an animal model of depression and patients with clinical depression and report that dysfunction of the Fos-mediated transcription network in the anterior cingulate cortex (ACC) confers a stress-induced social interaction deficit. Critically, CRISPR-Cas9–mediated ACC Fos knockdown causes social interaction deficits under stressful situation. Moreover, two classical second messenger pathways, calcium and cyclic AMP, in the ACC during stress differentially modulate Fos expression and regulate stress-induced changes in social behaviors. Our findings highlight a behaviorally relevant mechanism for the regulation of calcium- and cAMP-mediated Fos expression that has potential as a therapeutic target for psychiatric disorders related to stressful environments.

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Antidepressant Response and Stress Resilience Are Promoted by CART Peptides in GABAergic Neurons of the Anterior Cingulate Cortex

Cited by 12 publications

References 68 publications

Molecular diversity and connectivity of accessory olfactory system neurons

Molecular diversity and connectivity of accessory olfactory system neurons

Encore: Behavioural animal models of stress, depression and mood disorders

GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency

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