Antidepressant Therapy in Patients Undergoing Coronary Artery Bypass Grafting: The MOTIV-CABG Trial

Chocron, Sidney; Vandel, Pierre; Durst, Camille; Laluc, Frédéric; Kaili, Djamel; Chocron, Michael; Etievent, Joseph-Philippe

doi:10.1016/j.athoracsur.2013.02.035

Cited by 40 publications

(35 citation statements)

References 13 publications

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“…Similar conclusions were noted in a randomised clinical trial in which administration of escitalopram (10 mg per day) 2 to 3 weeks prior to CABG surgery did not result in any significant adverse outcomes in terms of bleeding. 21 This differential risk profile with respect to the type of surgery is intriguing and suggests that the SADassociated bleeding risk cannot be generalised to all surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Influence of pre‐operative use of serotonergic antidepressants (SADs) on the risk of bleeding in patients undergoing different surgical interventions: a meta‐analysis

Singh

Achuthan

Chakrabarti

et al. 2014

Pharmacoepidemiology and Drug

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Section: Discussionmentioning

confidence: 99%

Influence of pre‐operative use of serotonergic antidepressants (SADs) on the risk of bleeding in patients undergoing different surgical interventions: a meta‐analysis

Singh

Achuthan

Chakrabarti

et al. 2014

Pharmacoepidemiology and Drug

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“…Many prevention studies for CPSP have initiated gabapentin and other oral medications between 1 hour and 1 day prior to surgery [3,12,24,25,27,33,51,52,57,66,95,97,98,101,108,116,131,133,147,148,165]. One study initiated treatment with an antidepressant 2-3 weeks prior to coronary artery bypass surgery; however, chronic pain was only assessed as part of a composite quality of life measure [31]. …”

Section: Design Considerations In the Context Of 4 Illustrative Prmentioning

confidence: 99%

Research design considerations for chronic pain prevention clinical trials

Gewandter

Dworkin

Turk

et al. 2015

Pain

133

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Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses. We provide a detailed examination of 4 models of chronic pain prevention (i.e., chronic post-surgical pain, postherpetic neuralgia, chronic low back pain, and painful chemotherapy-induced peripheral neuropathy). The issues discussed can, in many instances, be extrapolated to other chronic pain conditions. These examples were selected because they are representative models of primary and secondary prevention, reflect persistent pain resulting from multiple insults (i.e., surgery, viral infection, injury, and toxic/noxious element exposure), and are chronically painful conditions that are treated with a range of interventions. Improvements in the design of chronic pain prevention trials could improve assay sensitivity and thus accelerate the identification of efficacious interventions. Such interventions would have the potential to reduce the prevalence of chronic pain in the population. Additionally, standardization of outcomes in prevention clinical trials will facilitate meta-analyses and systematic reviews and improve detection of preventive strategies emerging from clinical trials.

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“…Although the therapy had no effect on morbidity and mortality after CABG, depressed patients treated with escitalopram had a better quality of life and less pain after surgery. 370 Therefore, treating depression before CABG can lead to improved psychological outcomes after surgery.…”

Section: Mental Health and Cognitive Impairmentmentioning

confidence: 99%