Antidepressant Treatment Can Normalize Adult Behavioral Deficits Induced by Early-Life Exposure to Methylphenidate

Bolaños, Carlos A.; Willey, Matthew D.; Maffeo, Melissa L; Powers, Kyle D.; Kinka, Daniel W.; Grausam, Katie B.; Henderson, Ross P.

doi:10.1016/j.biopsych.2007.06.024

Cited by 58 publications

(55 citation statements)

References 75 publications

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“…A mouse was judged immobile when it stopped swimming and made only small movements to remain afloat. Immobility behaviors in the FST were expressed in immobility occurrence, assessed every 10 s over a period of 6 min (Bolanos et al, 2008). Recordings were evaluated by two experimenters, blind to the animals' genotypes.…”

Section: Experiments 1: Emotional Behavior Analysesmentioning

confidence: 99%

Role of corticosteroid binding globulin in emotional reactivity sex differences in mice

Minni

Medeiros

Helbling

et al. 2014

Psychoneuroendocrinology

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Section: Experiments 1: Emotional Behavior Analysesmentioning

confidence: 99%

Role of corticosteroid binding globulin in emotional reactivity sex differences in mice

Minni

Medeiros

Helbling

et al. 2014

Psychoneuroendocrinology

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“…To our knowledge there are no comparable neurobiological data in literature, but the present finding of unchanged striatal 5-HTT density indicates that other factors might underlie the increased depression-like behaviours in rodents exposed to MPH during preadolescence reducible by treatment with a selective 5-HT reuptake inhibitor (Bolanos et al 2008).…”

Section: Discussionmentioning

confidence: 77%

“…For example, exposing rodents to MPH during preadolescence resulted in increased depressionlike behaviours in adulthood manifested in enhanced vulnerability to stressful environments and anxietyeliciting situations, as well as reduced reactivity to natural rewards (Bolanos et al 2003;Carlezon et al 2003). These behavioural deficits could be reversed by subsequent treatment with a selective 5-HT reuptake inhibitor (Bolanos et al 2008). Nevertheless, the long-term influence of MPH on 5-HT metabolism including the 5-HT transporter (5-HTT) remains unclear.…”

Section: Introductionmentioning

confidence: 98%

Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD

Roessner

Manzke

Becker

et al. 2009

The World Journal of Biological Psychiatry

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Although stimulants as the treatment of choice are widely prescribed in ADHD, little is known about their long-term neurobiological effects. Hence, for the first time the present study examined the long-term effects of chronic methylphenidate (MPH) administration on striatal 5-hydroxytryptamine transporter (5-HTT) densities in an animal model of ADHD. First, it compared the normal development of striatal 5-HTT densities of spontaneously hypertensive rats (SHR) as an animal model of ADHD and Wistar Kyoto (WKY) rats as controls; binding of the highly selective ligand of 5-HTT [(3)H]paroxetine was determined on membrane preparations of the striatum of SHR and WKY rats on postnatal days 25, 50, and 90, i.e. from the time of weaning until adulthood. Second, the long-term effect of chronic administration of 2 mg/kg per day MPH at two different developmental stages (days 25-39 or 50-64) on the striatal 5-HTT density was examined in both rat strains at day 90. Long-term effects of MPH treatment on striatal 5-HTT density in adulthood could be ruled out in both healthy (WKY) and "ADHD" rats (SHR). But a higher striatal 5-HTT density in older SHR versus WKY rats might indicate ADHD specific changes in the 5-HT system that needs further investigation not only in animals.

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“…The test is a two-bottle choice paradigm performed according to the procedure as described (Bolanos et al, 2008). Briefly, rats were given access to two bottles (water and 30% sucrose solution) freely for 2 days.…”

Section: Sucrose Preference Test (Spt)mentioning

confidence: 99%

Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

Lin

Chang

Lin

2014

Pharmacology Biochemistry and Behavior

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Antidepressant Treatment Can Normalize Adult Behavioral Deficits Induced by Early-Life Exposure to Methylphenidate

Cited by 58 publications

References 75 publications

Role of corticosteroid binding globulin in emotional reactivity sex differences in mice

Role of corticosteroid binding globulin in emotional reactivity sex differences in mice

Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD

Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

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