Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats

Gobbi, Juliana Irani Fratucci De; Omoto, Ana Carolina Mieko; Siqueira, Tamires Ferreira; Matsubara, Luiz S.; Roscani, Meliza Goi; Matsubara, Beatriz Bojikian

doi:10.1016/j.physbeh.2015.02.037

Cited by 6 publications

(9 citation statements)

References 22 publications

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“…4). In rats, low Na also indicates depression, and antidepressant treatment may reduce salt intake (102,103) . The relationship of salt intake and mood is examined briefly below.…”

Section: Adult Salt Intakementioning

confidence: 99%

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Salt need needs investigation

Leshem

2020

Br J Nutr

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AbstractExpensive and extensive studies on the epidemiology of excessive Na intake and its pathology have been conducted over four decades. The resultant consensus that dietary Na is toxic, as well as the contention that it is less so, ignores the root cause of the attractiveness of salted food. The extant hypotheses are that most Na is infiltrated into our bodies via heavily salted industrialised food without our knowledge and that mere exposure early in life determines lifelong intake. However, these hypotheses are poorly evidenced and are meagre explanations for the comparable salt intake of people worldwide despite their markedly different diets. The love of salt begins at birth for some, vacillates in infancy, climaxes during adolescent growth, settles into separate patterns for men and women in adulthood and, with age, fades for some and persists for others. Salt adds flavour to food. It sustains and protects humans in exertion, may modulate their mood and contributes to their ailments. It may have as yet unknown benefits that may promote its delectability, and it generates controversy. An understanding of the predilection for salt should allow a more evidence-based and effective reduction of the health risks associated with Na surfeit and deficiency. The purpose of this brief review is to show the need for research into the determinants of salt intake by summarising the little we know.

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“…4). In rats, low Na also indicates depression, and antidepressant treatment may reduce salt intake (102,103) . The relationship of salt intake and mood is examined briefly below.…”

Section: Adult Salt Intakementioning

confidence: 99%

“…In animal studies, salt was found to mitigate stress and facilitate social behaviour, which are useful effects, while low Na and its related hormones were found to indicate depression (2,55,102,103,126) . The human data are less consistent.…”

Section: Conditioning Salt Preference Through Exertion Mood Health mentioning

confidence: 99%

Salt need needs investigation

Leshem

2020

Br J Nutr

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“…Male Wistar rats (260 to 280 g) had sham or AR surgeries induced by multiple retrograde puncture of the aortic valve leaflets under anesthesia (ketamine 80 mg/kg of bw plus xylazine 7mg/Kg bw, Vetbrands, Jacareí-SP) as described elsewhere 24,25,26 . All procedures were in accordance with the Animal Care and Use policies of the Institute of Biosciences of Botucatu, according to the Brazilian College of Animal Experimentation (COBEA, number 141/09) policies.…”

Section: Animal Model Of Armentioning

confidence: 99%

“…Animals that failed to meet these criteria were excluded. We analysed LV dimensions, wall thickness, ejection fraction, diastolic function, and cardiac output (i.e., ejection volume in the LV outflow tract-heart rate), as previously reported 24,25,26 .…”

Section: Echocardiographymentioning

confidence: 99%

Disrupted fluid balance and baroreflex sensitivity in acute aortic regurgitation

Leme¹,

Silva²,

Roscani³

et al. 2019

J. Biomed

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Acute aortic regurgitation (AR) causes abrupt volume overload to the heart. The implication of this acute volume overload concerning fluid balance and autonomic participation remains unknown. We studied fluid balance (sodium and water intake and excretion), autonomic modulation and heart rate variability (HRV) in acute AR rats. Male Wistar rats (260-280g) were submitted to sham or AR surgery by retrograde puncture of the aortic valves leaflets. The presence and severity of AR was confirmed by echocardiography exams one week after the surgeries. The left ventricule diastolic diameter and the left atrium area were bigger in acute AR than in sham rats. The fluid behavior was challenged by combining furosemide and captopril in low doses. This combined treatment induces water and sodium intake behavior within one hour. There was an increase in water intake and natriureses following a fluid depletion in acute AR rats. The daily intake and natriuresis were not altered. The diastolic arterial pressure was lower in AR than in sham and there were no changes in autonomic modulation. The study of HRV shows an increase in the high-frequency component in acute AR rats. However, there was a decrease in the spontaneous baroreflex sensitivity in these rats. In conclusion, the results show that an acute volume overload to the heart impairs since its onset not only the fluid balance but also baroreflex sensitivity.

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“…In animal models, the association between excessive salt intake and cognitive impairment were observed in experimental studies . Liu et al found that a high‐salt diet significantly impaired the spatial memory of C57BL/6J mice .…”

Section: Association Of Cognitive Impairment With Inflammatory Conditmentioning

confidence: 99%

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Abdoli

2017

Clinical & Exp Neuroim

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Salt is an important macronutrient that plays pivotal roles in physiological and pathophysiological conditions. High salt intake is an important cause of hypertension, cardiovascular disease and stroke. However, recent investigations uncovered the role of excessive salt intake in the induction of severe inflammatory reactions through augmentation of T helper-17 pathway and their inflammatory cytokines. In contrast, numerous studies have shown the role of inflammation in the pathophysiology of neuropsychiatric disorders (NPD). Here, it is hypothesized that high salt intake can increase the risk of NPD through salt-derived neural inflammations. Therefore, this hypothesis suggests that low-salt intake can decrease the risk of NPD. The present review discusses the potential role of excessive salt intake in the pathophysiology of NPD.

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Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats

Cited by 6 publications

References 22 publications

Salt need needs investigation

Salt need needs investigation

Disrupted fluid balance and baroreflex sensitivity in acute aortic regurgitation

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

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