2013
DOI: 10.1007/s00213-013-2972-5
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Antidepressant use and glycemic control

Abstract: In this representative population sample, antidepressant use was not associated with an increased risk of abnormalities in glycemic control or undetected diabetes. Positive findings from past research may be attributable to detection bias, in that individuals prescribed antidepressants may be more likely to be tested and diagnosed with diabetes.

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Cited by 21 publications
(18 citation statements)
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“…Furthermore, no association between using a single antidepressant subclass and A1C was observed among those with diabetes. This study generally supports the observations of Mojtabai (2013) who observed no cross-sectional association between antidepressant use and A1C level in a nationally-representative sample of individuals without diabetes. This study also extended Mojtabai's research with the inclusion of individuals with and without diabetes, and the inclusion of a multiple-subclass exposure category.…”
Section: Discussionsupporting
confidence: 91%
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“…Furthermore, no association between using a single antidepressant subclass and A1C was observed among those with diabetes. This study generally supports the observations of Mojtabai (2013) who observed no cross-sectional association between antidepressant use and A1C level in a nationally-representative sample of individuals without diabetes. This study also extended Mojtabai's research with the inclusion of individuals with and without diabetes, and the inclusion of a multiple-subclass exposure category.…”
Section: Discussionsupporting
confidence: 91%
“…The exposure of interest, antidepressant use, was self-reported in the SCCS baseline questionnaire. Following the methods of Mojtabai (2013), Deuschle (2013), and Hennings et al (2012), antidepressants were grouped by subclass; categories included only serotonin-norepinephrine reuptake inhibitors (SNRIs), only selective serotonin reuptake inhibitors (SSRIs), only tricyclic antidepressants (TCAs), only other subclasses (tetracyclic antidepressants, serotonin reuptake inhibitors, serotonin antagonist and reuptake inhibitors, or bupropion), multiple subclasses, and no antidepressant use.…”
Section: Methodsmentioning
confidence: 99%
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“…232 The topic of SSRIs and CVD has been examined in great detail among adults, and the current literature suggests that SSRIs may have a salutary effect on CVD (particularly citalopram and sertraline) and are unlikely to have a deleterious effect 231,233 ; however, there is evidence that SSRIs may confer a risk of obesity and possibly glycemic control problems. 234,235 This topic has received limited attention among youth to date. In a large study of adolescents with treatment-resistant depression, 12 weeks of treatment with venlafaxine (a serotonin and norepinephrine reuptake inhibitor; n=166) was associated with greater increases in diastolic blood pressure than treatment with SSRIs (n=168).…”
Section: Antidepressant Drugsmentioning
confidence: 99%
“…Future studies should examine as well more in detail whether antidepressants or mood stabilizers significantly modulate MetS risk. For example, previous studies [41,42] found that some antidepressants may, in some circumstances, reduce hyperglycemia, normalize glucose homeostasis and also increase insulin sensitivity, whereas others, including tricyclic antidepressants, may exacerbate glycemic dysfunction or have little effect on glucose homeostasis [43,44].…”
Section: Future Researchmentioning
confidence: 99%