Antidepressants and sexual dysfunction: a history

Healy, David

doi:10.1177/0141076819899299

Cited by 18 publications

(9 citation statements)

References 10 publications

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“…Neuromodulators for IBS, such as selective serotonin reuptake inhibitors and, to a lesser extent, tricyclic antidepressants are associated with sexual dysfunction. 98,99 Adverse effects include reduced libido, premature ejaculation, erectile dysfunction and dyspareunia. 100 Hence, counselling patients about these adverse effects prior to starting treatment and assessing sexual function at baseline and during treatment is required.…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Review article: Physical and psychological comorbidities associated with irritable bowel syndrome

Shiha

Aziz

2021

Aliment Pharmacol Ther

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Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders encountered by physicians in primary and secondary care. Patients with IBS commonly present with various extraintestinal complaints, which account for a substantial clinical and economic burden. The common extraintestinal comorbidities associated with IBS include anxiety, depression, somatisation, fibromyalgia, chronic fatigue syndrome, chronic pelvic pain, interstitial cystitis, sexual dysfunction and sleep disturbance. The presence of comorbidity in IBS poses a diagnostic and therapeutic challenge with patients frequently undergoing unnecessary investigations and interventions, including surgery. This review discusses the different physical and psychological comorbidities associated with IBS, the shared pathophysiological mechanisms and potential management strategies.

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Section: Sexual Dysfunctionmentioning

confidence: 99%

Review article: Physical and psychological comorbidities associated with irritable bowel syndrome

Shiha

Aziz

2021

Aliment Pharmacol Ther

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“…33 34 Although many of these adverse effects can improve on stopping, there is evidence that some adverse effects can persist after cessation, 52 including sexual dysfunction, now recognised as 'post-SSRI sexual dysfunction' by the EMA. 53 Patients who are considering stopping should be made aware of this possibility; equally so, patients considering starting should be aware that there is a small risk of permanent effects.…”

Section: Reviewmentioning

confidence: 99%

Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop

Horowitz

Wilcock

2021

DTB

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In England, the prescribing of antidepressants, primarily the newer generation antidepressant classes, has steadily increased over recent years. There is ongoing debate about how the efficacy of these drugs is viewed, their place in therapy and the harms associated with stopping them. Much of the evidence of their efficacy comes from short-term placebo-controlled trials which tend not to include outcomes that are of greatest relevance to patients, such as social functioning or quality of life, but rather restrict outcomes narrowly to symptom measures. On such measures these studies do not demonstrate clinically significant differences from placebo for depression. A range of adverse effects are also recognised, often greater in naturalistic studies of long-term antidepressants users than those measured in short-term efficacy studies, including emotional numbing, sexual difficulties, fatigue and weight gain. There is increasing recognition that withdrawal symptoms from antidepressants are common and that these symptoms can be severe and long-lasting in some patients. Recent guidance on how to stop antidepressants in a tolerable way has been presented by the Royal College of Psychiatrists. We believe that increasing awareness about the difficulty that some patients have in stopping antidepressants should lead to more cautious prescribing practice, with antidepressants given to fewer patients and for shorter periods of time. This article discusses the perceived benefits and harms of antidepressant use.

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“…Sexual dysfunction is one of the most commonly reported ADRs associated with antidepressant drugs, and this may potentially affect adherence to the therapy. Thus, it is more vital to develop novel treatments that target antidepressant-induced sexual dysfunction and/or can be used safely in mild to moderate depression without such unfavorable adverse events [38]. Dording et al (2012) examined the potential of adjunctive SAMe to improve sexual dysfunction over a 6-week monocentric randomized double-blind clinical trial [39].…”

Section: Antidepressant Efficacy Of Samementioning

confidence: 99%

The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach

et al. 2022

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Depression is a common and serious health issue affecting around 280 million people around the world. Suicidal ideation more frequently occurs in people with moderate to severe depression. Psychotherapy and pharmacological drugs are the mainstay of available treatment options for depressive disorders. However, pharmacological options do not offer complete cure, especially in moderate to severe depression, and are often seen with a range of adverse events. S-adenosyl methionine (SAMe) supplementation has been widely studied, and an impressive collection of literature published over the last few decades suggests its antidepressant efficacy. Probiotics have gained significant attention due to their wide array of clinical uses, and multiple studies have explored the link between probiotic species and mood disorders. Gut dysbiosis is one of the risk factors in depression by inducing systemic inflammation accompanied by an imbalance in neurotransmitter production. Thus, concomitant administration of probiotics may be an effective treatment strategy in patients with depressed mood, particularly in resistant cases, as these can aid in dysbiosis, possibly resulting in the attenuation of systemic inflammatory processes and the improvement of the therapeutic efficacy of SAMe. The current review highlights the therapeutic roles of SAMe and probiotics in depression, their mechanistic targets, and their possible synergistic effects and may help in the development of food supplements consisting of a combination of SAMe and probiotics with new dosage forms that may improve their bioavailability.

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Antidepressants and sexual dysfunction: a history

Abstract: In June 2019, in response to a petition lodged by the author in 2018, 1 the European Medicines Agency asked pharmaceutical companies to warn that sexual dysfunction can endure after antidepressant treatment stops. 2

Cited by 18 publications

References 10 publications

Review article: Physical and psychological comorbidities associated with irritable bowel syndrome

Review article: Physical and psychological comorbidities associated with irritable bowel syndrome

Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop

The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach

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