Antidepressants, Antipsychotics, Benzodiazepines, and the Breastfeeding Dyad

Malone, Kirsten L.; Papagni, Karla; Ramini, Sasha; Keltner, Norman L.

doi:10.1111/j.1744-6163.2004.00073.x

Cited by 29 publications

(41 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The researchers also should consider the factors that affect drug transfer and concentration in breast milk such as maternal plasma drug level adult half-life of the drug drug lipophilicity protein binding and days postpartum [25]. Accurate prediction of daily infant dose via breast feeding requires a model that takes into account: first that the composition of breast milk varies from the initial colostrums (which shows relatively higher protein concentration) to mature milk and thus drug concentrations change after the first 3 to 4 days of lactation and second that the milk composition varies even during a single breastfeeding session with milk expressed towards the end of a feeding having greater fat contents.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggested decrease risk of haematological cancers asthma diabetes mellitus obesity and hypercholesterolemia in infants and older individuals who were breastfed [10,24]. Additionally human milk feeding has been associated with slightly enhanced performance on tests of cognitive development and decreased rates of sudden infant death syndrome in the first year of life [24,25]. Breast feeding benefits for the mother include decreased postpartum bleeding and more rapid uterine involution decreased risk of breast and ovarian cancer and possibly decreased risk of osteoporosis in the postmenopausal period [24].…”

Section: Benefits/importance Of Breastfeedingmentioning

confidence: 99%

“…Infant exposure to psychotropic medications is greater during pregnancy through placental passage than during the postnatal period through breast milk that is much more selective [13,25]. However most drugs do pass into maternal milk [25].…”

Section: Treatment And/or Breastfeedingmentioning

confidence: 99%

“…However most drugs do pass into maternal milk [25]. The United States Food and Drug Administration do not approve any antidepressant medication for use during lactation [8,14,21].…”

Section: Treatment And/or Breastfeedingmentioning

confidence: 99%

See 3 more Smart Citations

Use of Antidepressants to Treat Postpartum Depression, During Breast Feeding

Fonseca¹,

Leal²

2014

J Depress Anxiety

View full text Add to dashboard Cite

Postpartum depression affects approximately 14.5% of women and it can affect both mother and infant. Therefore, rapid attention and treatment are imperative. The pharmacological approach often represents one of the most realistic options of treatment. However, women may be reluctant to take antidepressants because of the fear of adverse effects for the infant, since that most drugs pass into breast milk. The use of pharmacotherapy has not been extensively documented in this population. The objective of this review is to evaluate the risk benefit of using antidepressants during breastfeeding to treat postpartum depression.An electronic search was performed by using PubMed database, from January 2001 through December 2010. The search was limited to articles in the English language and to articles that relate human's research. Manual searches of bibliographies were also conducted to identify additional pertinent studies.The use of antidepressants that do not appear in infants' plasma, for which use during breastfeeding is better documented and at standard therapeutic doses is recommended, such as sertraline and paroxetine. Fluoxetine has a long half-life which can lead to a long infant exposition through breast milk and citalopram can cause adverse effects in infants exposed through breast milk. Therefore, citalopram and fluoxetine should not be used as first-line treatments. More information is needed about the use of the other antidepressants referred in this study.This study aims to emphasize the importance of postpartum depression treatment, always considering its repercussions for the breastfed infants. Studies are needed with larger samples to properly evaluate the short and long-term effects of antidepressants on infants exposed through breast milk, so that clinicians can create standard decisions regarding the treatment of postpartum depression, without putting infants at risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Benefits/importance Of Breastfeedingmentioning

confidence: 99%

Section: Treatment And/or Breastfeedingmentioning

confidence: 99%

“…However most drugs do pass into maternal milk [25]. The United States Food and Drug Administration do not approve any antidepressant medication for use during lactation [8,14,21].…”

Section: Treatment And/or Breastfeedingmentioning

confidence: 99%

See 2 more Smart Citations

Use of Antidepressants to Treat Postpartum Depression, During Breast Feeding

Fonseca¹,

Leal²

2014

J Depress Anxiety

View full text Add to dashboard Cite

show abstract

“…Vu les nombreux avantages de l'allaitement, à la fois pour la mère et l'enfant [1][2][3], les organisations professionnelles telles que l'American Academy of Pediatrics et la Canadian Pediatric Society, recommandent l'allaitement maternel exclusif des nourrissons pendant les six premiers mois après la naissance et la poursuite de l'allaitement jusqu'à l'âge d'un an ou plus [4]. Les bienfaits de l'allaitement sont d'ordre, aussi bien nutritionnel, immunologique, psychologique, émo-tionnel, économique que social [5].…”

Section: Introductionunclassified

Passage des benzodiazépines dans le lait maternel : aspects cliniques et analytiques

Khachman¹,

Gandia

Sena

et al. 2008

Ann Toxicol Anal

View full text Add to dashboard Cite

Résumé -Mots clés : Lait, suivi biologique thérapeutique, benzodiazépines, HPLC Abstract -Objective: To validate an HPLC analytical assay of benzodiazepines in milk to assess the degree of exposure of the breastfed infant and set up a therapeutic drug monitoring. Methods: The linearity, the recovery, the within-day repetability and inter-day reproductibility over three days of diazepam, desmethyldiazepam, bromazepam, oxazepam and lorazepam were studied with three different matrices, cow's milk Candia , freeze-dried milk dedicated for infants O-Lac Enfamil and mother breast milk. Midazolam was used as internal standard. The chromatographic system consisted of a Nucleosil column with an UV detection (254 nm). The flow of the pump was adjusted at 1.2 mL/min with an acquisition period of 20 min. Results: The linearity for diazepam, bromazepam and lorazepam ranged from 50 to 5000 ng/mL whereas for desmethyldiazepam and oxazepam, it ranged from 100 to 10 000 ng/mL (r 2 > 0.99). The recovery was around 100% (± 15%) for each tested benzodiazepine. Within-day and inter-day coefficients of variation (CV) for the five benzodiazepines ranged from -15.3% to 17.4%. Conclusion: The validated method is simple, fast and applicable to maternal milk samples containing benzodiazepines.

show abstract

Maternal prenatal anxiety, postnatal caregiving and infants' cortisol responses to the still‐face procedure

Grant

McMahon

Austin

et al. 2009

Developmental Psychobiology

121

View full text Add to dashboard Cite

This study prospectively examined the separate and combined influences of maternal prenatal anxiety disorder and postnatal caregiving sensitivity on infants' salivary cortisol responses to the still-face procedure. Effects were assessed by measuring infant salivary cortisol upon arrival at the laboratory, and at 15-, 25-, and 40-min following the still-face procedure. Maternal symptoms of anxiety during the last 6 months of pregnancy were assessed using clinical diagnostic interview. Data analyses using linear mixed models were based on 88 women and their 7-month-old infants. Prenatal anxiety and maternal sensitivity emerged as independent, additive moderators of infant cortisol reactivity, F (3, 180) = 3.29, p = .02, F (3, 179) = 2.68, p = .05 respectively. Results were independent of maternal prenatal depression symptoms, and postnatal symptoms of anxiety and depression. Infants' stress-induced cortisol secretion patterns appear to relate not only to exposure to maternal prenatal anxiety, but also to maternal caregiving sensitivity, irrespective of prenatal psychological state.

show abstract

Antidepressants, Antipsychotics, Benzodiazepines, and the Breastfeeding Dyad

Cited by 29 publications

References 41 publications

Use of Antidepressants to Treat Postpartum Depression, During Breast Feeding

Use of Antidepressants to Treat Postpartum Depression, During Breast Feeding

Passage des benzodiazépines dans le lait maternel : aspects cliniques et analytiques

Maternal prenatal anxiety, postnatal caregiving and infants' cortisol responses to the still‐face procedure

Contact Info

Product

Resources

About