Antidepressants for agitation and psychosis in dementia

Seitz, Dallas; Adunuri, Nikesh; Gill, Sudeep S.; Gruneir, Andrea; Herrmann, Nathan; Rochon, Paula A.

doi:10.1002/14651858.cd008191.pub2

Cited by 204 publications

(93 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recovery following a hip fracture tends to be particularly challenging for individuals with dementia 2 . Approximately 19% of all older individuals with hip fractures have dementia, and up to 40% of individuals with a hip fracture have some form of cognitive impairment, which may include dementia, delirium, mild cognitive impairment or other post-operative cognitive decline 3 .…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review

Resnick

Beaupré

McGilton

et al. 2016

Journal of the American Medical Directors Association

View full text Add to dashboard Cite

Purpose Currently, most rehabilitation services for individuals who sustain a hip fracture are not designed to meet the complex needs of those who also have cognitive impairment. The goal of this review was to identify current best practices for rehabilitation in long term care settings and approaches to optimize outcomes among individuals with dementia and other cognitive impairments post hip fracture. Procedures The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (the PRISMA Statement) was used to guide the review. Five electronic databases, including Pubmed, EMBASE, CINAHL (EBSCO), Medline (EBSCO) and PsycINFO (EBSCO), were searched for intervention studies published in English language journals. Studies were eligible if they focused on rehabilitation interventions post hip fracture among older individuals (≥ 65 years) with cognitive impairment who were living in or transferred to long-term care or post-acute/rehabilitation settings post hip fracture. Studies were excluded if they did not enroll individuals with cognitive impairment, the study was descriptive without any intervention content, or the intervention components were only medication, surgical approach or medical treatment. Main Findings A total of 4,478 records were identified, 1915 of which were duplicative, 2,563 were relevant based on title and after careful review seven studies were included. Two included studies were randomized controlled trials, one was a single group pre- and post-test, one a descriptive comparison between those with and without cognitive impairment, one a case controlled matched trial, one a nonequivalent groups trial, and one a case report. The interventions varied between manipulating the type and amount of exercise or testing multifactorial issues including environmental interventions and the use of an interdisciplinary team to address psychosocial factors, medication management, use of assistive devices, and specific preferences or concerns of the individuals. Conclusions The evidence summarized in this review suggests that it is feasible to implement rehabilitation programs focused on individuals with cognitive impairment in post-acute care settings. Moreover, there was evidence to suggest that intensive rehabilitation and exercise activities are beneficial, although innovative approaches may be needed to engage individuals with cognitive impairment.

show abstract

Section: Introductionmentioning

confidence: 99%

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review

Resnick

Beaupré

McGilton

et al. 2016

Journal of the American Medical Directors Association

View full text Add to dashboard Cite

show abstract

“…Важно помнить, что цита-лопрам должен быть исключен при высоком риске возник-новения аритмии (увеличение интервала QT на электрокар-диограмме -ЭКГ, гипокалиемия, снижение уровня магния, развитие сердечной недостаточности) [20][21][22]. В 2011 г. был проведен систематический анализ 9 рандомизированных контролируемых исследований, в которых изучали влияние антидепрессантов на нейропсихиатрические симптомы [21,23,24].…”

Section: (табл 2)unclassified

Current management tactics for patients with dementia

Ковров

Kosivtsova

Makhinov

2018

RJTAO

View full text Add to dashboard Cite

“…Though, AD is associated with cognitive dysfunction with usual initial clinical presentation with memory complaints, it is prudent to identify the behavioral and psychological symptoms of dementia (BPSD), which can be present even in the mild form of the AD. BPSD consists of abnormalities of thought, perception, mood, and behavior in dementia patients [3, 4], which were suggested as core symptoms of dementia along with cognitive symptoms by Tariot et al [5]. …”

Section: Introductionmentioning

confidence: 99%

Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer’s Disease?

et al. 2018

View full text Add to dashboard Cite

Background: There are studies showing the relation between serum B12, folate and Behavioral and Psychological symptoms of Dementia (BPSD) in Alzheimer’s disease (AD). Serum levels of these vitamins do not reflect actual disease status and therefore checking the serum Homocysteine level is considered a better test. Homocysteine has been found to be associated with cognitive impairment and various psychiatric disorders. Purpose: This study was planned to identify the correlation between serum homocysteine levels and BPSD in AD patients. Methods: AD patients (n = 18) and healthy controls (n = 18) were included in the study. Diagnosis of AD was confirmed using International Classification Disease-10. AD patients were assessed using Mini Mental Status Examination (MMSE), Clinical Dementia Rating scale (CDR), Global Deterioration scale (GDS), and Neuropsychiatric inventory (NPI). Healthy controls were assessed on MMSE and Mini International Neuropsychiatric Interview. Serum homocysteine, vitamin B12, and folate levels were measured in all study subjects. Results: Patients with AD had statistically significant higher serum levels of homocysteine as compared to the control group, while the levels of vitamin B12 and folate did not differ significantly. There was statistically significant positive correlation of serum homocysteine levels with total NPI score as well as with NPI sub-domains particularly delusion, agitation/aggression, and depression/dysphoria. Serum homocysteine levels did not correlate significantly with MMSE, CDR, and GDS scores. Conclusion: Correlation was observed between serum homocysteine levels and behavioral and psychological symptoms of AD. There is a possibility of etiological role, but the underlying pathophysiological mechanisms need to be elucidated. Whether patients will benefit or not with supplements of vitamin B12 and folate requires further research. This was a cross-sectional study and findings should not be generalized. Further prospective longitudinal studies with a large number of patients are needed.

show abstract

Antidepressants for agitation and psychosis in dementia

Cited by 204 publications

References 83 publications

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review

Current management tactics for patients with dementia

Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer’s Disease?

Contact Info

Product

Resources

About