Antidepressants for patients with tinnitus

Baldo, Paolo; Dorée, Carolyn; Molin, Paola; McFerran, Don; Cecco, Sara

doi:10.1002/14651858.cd003853.pub3

Cited by 102 publications

(48 citation statements)

References 83 publications

(51 reference statements)

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“…Treatment with antidepressants improved comorbid depressive or anxiety disorders [144], but did not reduce tinnitus [145]. A meta-analysis of anticonvulsant treatment with carbamazepine, gabapentin and lamotrigine did not reveal additional benefits compared to placebo in controlled studies [146].…”

Section: Treatment Of Tinnitusmentioning

confidence: 99%

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

2016

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Tinnitus is a phantom auditory sensation that reduces quality of life for millions worldwide and for which there is no medical cure. Most cases are associated with hearing loss caused by the aging process or noise exposure. Because exposure to loud recreational sound is common among youthful populations, young persons are at increasing risk. Head or neck injuries can also trigger the development of tinnitus, as altered somatosensory input can affect auditory pathways and lead to tinnitus or modulate its intensity. Emotional and attentional state may play a role in tinnitus development and maintenance via top-down mechanisms. Thus, military in combat are particularly at risk due to combined hearing loss, somatosensory system disturbances and emotional stress. Neuroscience research has identified neural changes related to tinnitus that commence at the cochlear nucleus and extend to the auditory cortex and brain regions beyond. Maladaptive neural plasticity appears to underlie these neural changes, as it results in increased spontaneous firing rates and synchrony among neurons in central auditory structures that may generate the phantom percept. This review highlights the links between animal and human studies, including several therapeutic approaches that have been developed, which aim to target the neuroplastic changes underlying tinnitus.

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Section: Treatment Of Tinnitusmentioning

confidence: 99%

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

2016

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“…Delayed hearing loss progression has been shown in transgenic mice with ER stress inhibitor treatment (Hu et al, 2016). Evidence of serotonin receptor mediated pathway involvement has been proposed from an apparent beneficial outcome of antidepressant usage among tinnitus patients (Baldo et al, 2012). Other pathways reaching significance include RAS, vascular smooth muscle contraction, coenzyme A biosynthesis, and NDK dynamin pathways (Gilles et al, 2017).…”

Section: Complex Genetics Approachesmentioning

confidence: 99%

Genetics of Tinnitus: Still in its Infancy

et al. 2017

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Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade. Nine studies have examined genes in a case-control association approach. Recently, a genome-wide association study has highlighted several potentially significant pathways that are implicated in tinnitus. Two twin studies have calculated a moderate heritability for tinnitus and disclosed a greater concordance rate in monozygotic twins compared to dizygotic twins. Despite the more recent data alluding to genetic factors in tinnitus, a strong association with any specific genetic locus is lacking and a genetic study with sufficient statistical power has yet to be designed. Future research endeavors must overcome the many inherent limitations in previous study designs. This review summarizes the previously embarked upon tinnitus genetic investigations and summarizes the hurdles that have been encountered. The identification of candidate genes responsible for tinnitus may afford gene based diagnostic approaches, effective therapy development, and personalized therapeutic intervention.

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“…People suffering from tinnitus go through tough time as a result of associated psychosocial [emotional and behavioural] problems which include severe headache, negative thoughts, dizziness, hearing problem, anxiety, irritation, annoyance, concentration problem, sleep difficulties, depression and poor attention focus [7]. Studies have shown that the quality of life is reduced in patients suffering from the aforementioned problems [16,19]. Meanwhile, it is noteworthy that psychoacoustical characterisation of tinnitus cannot fully determine the level of discomfort evoked by this condition.…”

Section: Tinnitus: Meaning and Effects On The Elderly Population 21 mentioning

confidence: 99%

Audiological Tinnitus Management: An Essential Audiological Protocol for Elderly Patients with Comorbidity of Hypertension and Tinnitus

Osisanya¹

2019

Management of Tinnitus - The Enriching Views of Treatment Options

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Elderly population with comorbidity of hypertension and tinnitus is increasing across the world, and the dilemma in the management of such elderly patients across the neurology and audiology/otology clinics seems enormous due to the attendant effects of such health-related comorbid conditions and ageing. This has been observed to have negative effect on the general well-being of quite a number of the elderly patients identified with the comorbid health conditions. It has also increased the tinnitus severity and related psychosocial reactions of the elderly patients. Worse still, the situation causes undulating increase in the prevalence of the comorbid condition of advanced age both male and female irrespective of cultural differences. Due to the aforementioned, this chapter is written with the aim of highlighting the efficacy of audiological tinnitus management options considered essential in the rehabilitation of individuals with comorbidity of hypertension and tinnitus. The chapter also discusses the benefits of combined therapies in rehabilitating elderly patients with comorbidity of hypertension and tinnitus and concluded with some useful recommendations for effective management of the comorbid condition.

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Antidepressants for patients with tinnitus

Abstract: There is as yet insufficient evidence to say that antidepressant drug therapy improves tinnitus.

Cited by 102 publications

References 83 publications

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

Genetics of Tinnitus: Still in its Infancy

Audiological Tinnitus Management: An Essential Audiological Protocol for Elderly Patients with Comorbidity of Hypertension and Tinnitus

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