Antidepressants for patients with tinnitus

Baldo, Paolo; Dorée, Carolyn; Lazzarini, Renzo; Molin, Paola; McFerran, Don

doi:10.1002/14651858.cd003853.pub2

Cited by 103 publications

(96 citation statements)

References 59 publications

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“…66 Drugs from several broad categories have been tested for eff ect on tinnitus. Tricyclic antidepressants and selective serotonin-reuptake inhibitors are not eff ective at reducing tinnitus, 67 but they might have a role in management of any concomitant psychological distress. Favourable results have been reported from one study of the benzodiazepine alprazolam, 68 but the research quality was not suffi cient for reliable conclusions to be drawn.…”

Section: Drug Treatmentsmentioning

confidence: 99%

“…Consequently, with the exception of CBT, 43,44 evidence for the eff ectiveness of diff erent treat ment strategies is insuffi cient. 40,47,57,67,98 Investigators under taking a UK-wide consultation of patients and clinicians made a priority list of ten unanswered questions (panel), 99,100 many of which could be addressed through high-quality randomised controlled trials.…”

Section: Clinical Trials In Tinnitusmentioning

confidence: 99%

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Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

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1,063

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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Section: Drug Treatmentsmentioning

confidence: 99%

Section: Clinical Trials In Tinnitusmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

Self Cite

1,063

911

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“…The methodological quality of treatment trials is heterogeneous in the extreme, as emphasized in all available Cochrane meta-analyses that touch on tinnitus (19)(20)(21)(22)(23)(24)(25). Accordingly, efforts are being made to improve quality standards in clinical trials of the treatment of tinnitus (25)(26)(27)(28).…”

Section: Knowledge Basementioning

confidence: 99%

Chronic Tinnitus

Kreuzer

Vielsmeier²,

Langguth³

2013

Deutsches Ärzteblatt International

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“…Attempts at symptomatic relief have included antidepressants (e.g. amitriptyline) [27], anxiolytics (e.g. .…”

Section: Treatmentmentioning

confidence: 99%

“…A number of recent studies recommend individualized management programs utilizing multimodal strategies designed to address the specific needs of each patient [11,27,35,36].…”

Section: Treatmentmentioning

confidence: 99%

Pathophysiology and Treatment of Tinnitus: An Elusive Disease

Atik

2011

Indian J Otolaryngol Head Neck Surg

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Tinnitus is a perception of sound in proximity to the head with the absence of an external source. It is estimated to occur in 15-20% of the world's population, with 1-3% of cases severely affecting quality of life. Severe tinnitus is frequently associated with depression, anxiety and insomnia. Tinnitus has been associated with a variety of risk factors, including prolonged noise exposure, head and neck injury and infection. The most recent pathophysiologic theory of tinnitus suggests that the central nervous system is the source or ''generator'' of this condition. However, treatment modalities are still aimed at lessening the awareness of tinnitus and its impact on quality of life rather than attaining a definitive cure. Currently, no drug is available that has demonstrated replicable, long-term reduction of tinnitus impact in excess of placebo effects. However, the market value of such an agent is estimated to be $1.1 billion, with a potential for increase with an aging and longer-living population. This review assesses the current developments in the pathophysiology and treatment for tinnitus, which remains a chronic and debilitating condition.

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Antidepressants for patients with tinnitus

Abstract: There is insufficient evidence to say that antidepressant drug therapy improves tinnitus.

Cited by 103 publications

References 59 publications

Tinnitus

Tinnitus

Chronic Tinnitus

Pathophysiology and Treatment of Tinnitus: An Elusive Disease

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