Antidepressants in urban wastewater treatment plant: occurrence, removal and risk assessment

doi:10.30955/gnj.002054

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…The Risk Quotient (RQ) for FLX indicates a medium to high risk to aquatic species, with a calculated RQ of 1.51 4 , 5 . Several attempts to remove FLX from water were unsuccessful because they did not completely remove the FLX 6 , 7 . Several technologies are generally available for removal of pharmaceuticals from wastewater streams such as advanced oxidation process, heterogeneous photocatalysis, ozonation, electrochemical oxidation, membrane treatment, and adsorption 8 .…”

Section: Introductionmentioning

confidence: 99%

Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant

Mahgoub,

Essam,

Eldin

et al. 2024

Sci Rep

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Fluoxetine (FLX) is one of the most persistent pharmaceuticals found in wastewater due to increased use of antidepressant drugs in recent decades. In this study, a nanocomposite of ternary ZnCoAl layered double hydroxide supported on activated carbon (LAC) was used as an adsorbent for FLX in wastewater effluents. The nanocomposite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis (BET). The adsorption investigations showed that the maximum removal capacity was achieved at pH 10, with a 0.1 g/L adsorbent dose, 50 mL volume of solution, and at a temperature of 25 °C. The FLX adsorption process followed the Langmuir–Freundlich model with a maximum adsorption capacity of 450.92 mg/g at FLX concentration of 50 µg/mL. Density functional theory (DFT) computations were used to study the adsorption mechanism of FLX and its protonated species. The safety and toxicity of the nanocomposite formed from the adsorption of FLX onto LAC (FLX-LAC) was investigated in male albino rats. Acute toxicity was evaluated using probit analysis after 2, 6, and 24 h to determine LD50 and LD100 values in a rat model. The FLX-LAC (20 mg/kg) significantly increased and lengthened the sleep time of the rats, which is important, especially with commonly used antidepressants, compared to the pure standard FLX (7 mg/kg), regular thiopental sodium medicine (30 mg/kg), and LAC alone (9 mg/kg). This study demonstrated the safety and longer sleeping duration in insomniac patients after single-dose therapy with FLX-LAC. Selective serotonin reuptake inhibitors (SSRIs) like FLX were found to have decreased side effects and were considered the first-line mood disorder therapies.

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Section: Introductionmentioning

confidence: 99%

Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant

Mahgoub,

Essam,

Eldin

et al. 2024

Sci Rep

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Adsorption of pharmaceuticals from biologically treated municipal wastewater using paper mill sludge-based activated carbon

Silva

Jaria

Otero

et al. 2019

Environ Sci Pollut Res

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43A waste-based alternative activated carbon (AAC) was produced from paper mill sludge 44 under optimized conditions. Aiming its application in tertiary wastewater treatment, 45 AAC was used for the removal of carbamazepine, sulfamethoxazole and paroxetine 46 from biologically treated municipal wastewater. Kinetic and equilibrium adsorption 47 experiments were run under batch operation conditions. For comparison purposes, they 48 were also performed in ultrapure water and using a high-performance commercial AC 49 (CAC). Adsorption kinetics was fast for the three pharmaceuticals and similar onto 50 AAC and CAC in either wastewater or ultrapure water. However, matrix effects were 51 observed in the equilibrium results, being more remarkable for AAC. These effects were 52 evidenced by Langmuir maximum adsorption capacities (qm, mg g -1 ): for AAC, the 53 lowest and highest qm were 194 ± 10 (SMX) and 287 ± 9 (PAR), in ultrapure water, and 54 47 ± 1 (SMX) and 407 ± 14 (PAR), in wastewater; while for CAC, the lowest and 55 highest qm were 118 ± 7 (SMX) and 190 ± 16 (PAR) in ultrapure water, and 123 ± 5 56 (SMX) and 160 ± 7 (CBZ) in wastewater. It was found that the matrix pH played a key 57 role in these differences by controlling the surface electrostatic interactions between 58 pharmaceutical and AC. Overall, it was evidenced the need of adsorption results in real 59 matrices and demonstrated that AAC is a promising option to be implemented in tertiary 60 wastewater treatments for pharmaceuticals' removal. 61 62 63 64 65 66 67 68 69

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Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity

Rodrigues

Nascimento

Moreno

et al. 2020

Journal of Environmental Sciences

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Antidepressants in urban wastewater treatment plant: occurrence, removal and risk assessment

Cited by 6 publications

References 25 publications

Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant

Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant

Adsorption of pharmaceuticals from biologically treated municipal wastewater using paper mill sludge-based activated carbon

Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity

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