Antidermatophytic activities of nine (9) essential oils

Jules-Roger, Kuiate; Kuate, SP; Kemadjou, NE; Djokoua, S; Zifac, F; Foko, J.

doi:10.4314/ecajps.v7i1.9705

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…The antibacterial activity of C. melanantha and E. floribundus is also reported here for the first time. However these plants were previously reported for their antifungal activities [ 29 – 32 ]. The antibacterial activities of extracts from Zehneria scobra and Nauclea latifolia [ 33 , 34 ] were reported on some bacteria: The present study therefore provides additional information on the activity of these plants against MDR Gram-negative phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Djeussi

Noumedem

Ngadjui

et al. 2016

BMC Complement Altern Med

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BackgroundBacterial Infections involving multi-drug resistant (MDR) phenotypes constitute a worldwide health concern. The present work was designed to assess the antibacterial properties of the methanol extracts of six medicinal plants (Anthocleista schweinfurthii, Nauclea latifolia, Boehmeria platyphylla, Caucalis melanantha, Erigeron floribundus and Zehneria scobra) and the effects of their associations with antibiotics on MDR Gram-negative bacteria over-expressing active efflux pumps.MethodsThe antibacterial activities and the ability to potentiate antibiotic effects of the methanol extracts the tested plants were evaluated in vitro against twenty eight Gram-negative bacteria expressing MDR phenotypes, using broth microdilution method. The phytochemical screening of these extracts was also performed using standard methods.ResultsAll tested extracts displayed moderate to low antibacterial activity on at least 14.3 % of the 28 tested bacteria, with MIC values ranged from 128 to 1024 μg/mL. The best antibacterial spectrum was observed with Naulcea latifolia bark extract. Extracts from A. schweinfurthii fruits, N. latifolia stem bark, Z. scobra and N. latifolia leaves showed synergistic effects with many antibiotics against MDR bacteria.ConclusionThe overall results of the present study provide information for the possible use of the studied plants, especially Nauclea latifolia in the control of Gram-negative bacterial infections including MDR species as antibacterials as well as resistance modulators.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1105-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Djeussi

Noumedem

Ngadjui

et al. 2016

BMC Complement Altern Med

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“…montana showed powerful antifungal activity against anthropophilic fungus, Microsporum audouinii with MIC values of 1 and 0.5 mg/mL, respectively. [116] Different antifungal activities are also observed in L. pterodonta essential oils collected from four areas (Kunming, Lijiang, Puer and Xinping) in Yunnan, China, with high content of 2,5-dimethoxy-p-cymene (36.75 %), γ-eudesmol (20.32 %), β-caryophyllene (32.71 %) and β-pinene (30.42 %), respectively. The different compositions of the oils are probably responsible for the different activities found against fungi, as reported for bacteria in the last section.…”

Section: Antifungal Activitiesmentioning

confidence: 99%

The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review

Getahun

Sharma

Gupta

2019

Chemistry & Biodiversity

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Most species of the genus Laggera are often used in traditional and folk medicines for the treatment of jaundice, inflammation, leukemia, removing phlegm, bronchitis and bacterial diseases. The essential oils obtained from Laggera plants are rich sources of oxygenated monoterpenes and sesquiterpenes. Among oxygenated monoterpenes, aromatic ether 2,5‐dimethoxy‐p‐cymene is the most abundant and dominant compound of many essential oils of the Laggera species. Till today, to the best of our knowledge, chemical compounds of the essential oils and/or extracts of only eight Laggera species were reported from different countries. Thus, this review presents the chemical compositions and biological activities of the essential oils of these plants studied in thirteen countries. In addition, it discusses the reported ethnobotanical and ethnopharmacological information as well as biological activities of the extracts and some of the isolated compounds of Laggera plants species.

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“…Through in vitro studies, the antidermatophytic potency of the extracts was evaluated. The activity was observed in the order petroleum ether >hexane > ethylacetate >chloroform >methanol and also the effect of DMSO on the M. gypseum growth was recorded at 1-5 % inhibition in the culture medium which is quiet lesser than the inhibition rate of 20-50 % observed in T. tonsurans by Chan 13 whereas the fraction 1 possess only hydrocarbon monoterpenes with α-pinene and sabiene as major components 15 . Since the phytocompounds are the decisive reason behind for the plants various potential activities, the phytocompounds of E. littorale that are already reported are evaluated for its inhibitory activity mainly against the chitinase and 1, 3 β-D glucan synthase enzymes.…”

Section: Discussionmentioning

confidence: 88%

In Vitro and in Silico Approach to Evaluate the Anti-Dermatophytic Activity of Enicostemma Littorale Blume

Muthusami¹,

Muthusamy²,

Manoharan³

et al. 2013

Int. Res. J. Pharm.

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Dermatophytes are the causative agents of superficial skin infections, dermatophytoses, which are capable of invading and digesting keratin. The current usage of synthetic drugs leads to either side effects in human or resistant fungal varieties due to prolonged use. Hence the present study aims at finding leads from phytocompounds to target the enzymes involved in maintaining fungal cell wall integrity, namely, 1, 3 β-D glucan synthase and chitinase, important enzyme having a role in morphogenesis. Docking analysis was carried out for the above targets with already reported phytocompounds of Enicostemma axillare (syn. littorale) Blume and compared with the specific synthetic drugs to evaluate their efficacy as fungal inhibitors using Glide software. The in vitro study was carried out for E. littorale extract against Microsporum gypseum. The significant results were observed with the petroleum ether extract of the aerial parts of E. littorale at a concentration of 3000 µg/ml

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Antidermatophytic activities of nine (9) essential oils

Cited by 4 publications

References 3 publications

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review

In Vitro and in Silico Approach to Evaluate the Anti-Dermatophytic Activity of Enicostemma Littorale Blume

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