Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

Abstract

BackgroundMoringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.MethodsThe aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan’s in diabetic rats. The plant material reduced the post-prandial glucose level (P < 0.001) at the dose of 750 mg/kg.ConclusionThese findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.

Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana

“…In the first 60 minutes, the BGL decrease by BFPP is even greater than those presented by the whole extract. This fact suggests that the active hypoglycemic compounds of calyces from P. peruviana extract are in the butanolic fraction similar to reported to other plants (Borar et al, 2011;Toma et al, 2015;Ibrahim and Islam, 2017). According to previous reports that identify rutin as major flavonoid in the hydroethanolic extract of calyces from P. peruviana and the evidence of hypoglycemic effect of this compound and its role in the glucose homeostasis by different mechanisms like secretagogue of insulin and stimulating of glucose uptake in muscle (Kappel et al, 2013a;, is possible to relate this flavonoid to the observed effect.…”

Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes

“…DM is a main cause of morbidity and mortality worldwide [2]. It is considering a metabolic disorder characterized by hyperglycemia, which caused by the deficiency in insulin secretion within type 1 diabetes (T1DM), and it is the main a feature of uncontrolled type 2 diabetes (T2DM) along with insulin resistance.…”

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of&lt;i&gt; Asparagus racemosus&lt;/i&gt; Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

“…The effect of combination treatment was significantly decreased the levels of SGPT, SGOT and TP liver enzyme levels when compared to the disease control rats and monotherapy of antidiabetic drug indicated improvement in liver dysfunctions. Toma et al, in the study on Moringa stenopetala leaves extracts in rats claimed considerably reduced in the hepatic enzymes levels that cause liver damage [84].…”