Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis

Okokon, Jude E.; Antia, Bassey S.; Udobang, John A.

doi:10.1016/s2221-1691(12)60076-8

Cited by 26 publications

(13 citation statements)

References 13 publications

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“…The extract and fractions were more active than the reference drug (glibenclamide). The results suggest that the plant could be a good candidate in the management of diabetes (Okokon et al, 2012). Bassey et al (2009) reported that the leaf extract of the plant exhibited a significant antiplasmodial activity against Plasmodium beighei both in the 4-day early infection test and in established infection.…”

Section: Anthocleista Djalonensis a Chevy -Gentianaceaementioning

confidence: 99%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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Breast cancer is the leading malignancy in the South Western Nigeria; it is second to cancer of the cervix in the northwest. In north-central, 22.41% of new cancer was registered for breast cancer in five years and accounted for 35.41% of all cancers in women. The limitations of orthodox drugs such as cost, accessibility, effectiveness, and side effects necessitate the search for cheap, safe and effective phytomedicine in cancer management. Thus, this paper reviewed twenty plants used traditionally for the management of breast cancer; this was with a view to presenting them for future research activities and scientific validation of their potency in cancer regimen.

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Section: Anthocleista Djalonensis a Chevy -Gentianaceaementioning

confidence: 99%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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“…alone or in combination with CF (100 and 200 mg/kg bw) or 10 mg/kg bw glibenclamide (GB). The choice of doses for chloroform fraction (CF) of A. vogelii and GB used in this study was informed by literature (Osadebe et al, 2014;Okokon et al, 2012) and results of a pilot study conducted. Blood samples were collected prior to injection and at 15, 30, 60 and 120 min post injection for measurement of glucose concentrations.…”

Section: Acute In Vivo Studiesmentioning

confidence: 99%

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes

Anyanwu

Iqbal

Khan

et al. 2019

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Anthocleista vogelii Planch is a medicinal plant traditionally used in West Africa for the management and treatment of diabetes mellitus. Aim of the study: To determine the antidiabetic activities of chloroform fraction (CF) of Anthocleista vogelii Planch root bark in rats with diet-and alloxan-induced obesity-diabetes. Materials and Methods: Inhibitory activities of CF against α-amylase and α-glucosidase activities were determined in vitro. Three weeks old rats were fed with high-fat diet for 9 weeks to induce obesity prior to further induction of diabetes using alloxan (150 mg/kg body weight, i.p.). Blood glucose levels and body weight were measured every 7 days throughout the experiment. Glucose tolerance was assessed in normal and CF-treated rats on day 21. Terminal blood samples were collected from sacrificed animals for the measurement of serum insulin levels. Pancreases were excised from treated and untreated animals for histopathological examination. Results: LCMS/MS chromatographic profile of CF via positive and negative modes revealed 13 and 23 compounds respectively. Further analysis revealed quebrachitol (QCT), loganin, sweroside, oleoside 11-methyl ester and ferulic acid, which have been previously reported for their antidiabetic activities, as constituents of CF. CF inhibited activities of α-amylase (IC 50 = 51.60 ± 0.92 µg/ml) and α-glucosidase (IC 50 = 5.86 ± 0.97 µg/ml) in a dose-dependent manner. Treatment of animals with obesity-diabetes with 100 and 200 mg/kg CF significantly improved glucose tolerance (P<0.001) and enhanced serum insulin levels (P<0.05) compared to diabetic control rats. Conclusions: Antidiabetic activities of CF might be mediated via inhibition of α-amylase and αglucosidase activities, and enhancement of insulin and leptin sensitivity in obesity-diabetes rats. This study further substantiates the traditional use of A. vogelii in the management and treatment of diabetes in Africa and encourages further studies to investigate its mechanism of action.

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“…[4] Diabetes mellitus is one of the fatal disorders in the world and it is an 6 th leading cause of death. [5] The death rate in diabetic people is double to that of normal people. Diabetes mellitus affects many major organs of body.…”

Section: Introductionmentioning

confidence: 99%

The Antidiabetic and Antioxidant Activity of Coccinea Grandis Voigt Stem Extract in Streptozotocin Induced Diabetic Rats

Momin¹,

Yeligar

2019

J. Drug Delivery Ther.

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Objective: In the present study, the antidiabetic and antioxidant study of stem part of Coccinea grandis Voigt plant extracts in Streptozotocin induced diabetic rats were investigated. Materials and methods: Fifty four Wistar albino rats were used with nine groups and with six rats in each group. 45 mg/kg body weight streptozotocin was administered to group 2 to 9. Group 2 was diabetic control. Group 3 was given with glimepiride as standard drug. Group 4 and 5 were given petroleum ether extract 250 and 500 mg/kg respectively. Group 6 and 7 were given 250 and 500 mg/kg chloroform extract respectively. Group 8 and 9 were given 250 and 500 mg/kg hydro alcoholic extract respectively. Antidiabetic activity of the extracts was assessed by serum glucose level on glucose kit. Superoxide dismutase (SOD), Catalase (CAT) and lipid peroxidation studies were assessed with histopathology. Result: The chronic study data on diabetic rats cleared the administration of all extracts significantly reduced blood glucose level and lipid peroxidation level with better antioxidant activity. Conclusion: From the study, the petroleum ether, chloroform and hydro alcoholic extracts of stem part of Coccinea grandis Voigt plant have shown antidiabetic and antioxidant potential. Key Words: Antidiabetic activity, antioxidant activity, Lipid peroxidation, Superoxide dismutase, Catalase.

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Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis

Cited by 26 publications

References 13 publications

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes

The Antidiabetic and Antioxidant Activity of Coccinea Grandis Voigt Stem Extract in Streptozotocin Induced Diabetic Rats

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