Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin–induced diabetic rats

Chikhi, Ilyas; Allali, Hocine; Dib, Mohammed El Amine; Medjdoub, Houria; Tabti, Boufeldja

doi:10.1016/s2222-1808(14)60501-6

Cited by 69 publications

(68 citation statements)

References 13 publications

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“…In addition, the OGTT in normoglycemic rats was improved demonstrating a marked antihyperglycemic activity of t-CA, which was enhanced in the SNEDDS formulation. This may involve a potentiation of insulin from the remaining b-cells [Chikhi et al, 2014] and is consistent with reports where cinnamic acid has been observed to have insulin secreting activity [Adisakwattana et al, 2008], and can activate insulin mediated glucose transport via the involvement of GLUT4 in L6 myotubes [Lakshmi et al, 2009].…”

Section: Discussionsupporting

confidence: 91%

Self‐Nanoemulsifying Drug Delivery System of trans‐Cinnamic acid: Formulation Development and Pharmacodynamic Evaluation in Alloxan‐induced Type 2 Diabetic Rat Model

Wang

Deng

et al. 2015

Drug Development Research

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The objective of this study was to formulate a self-nanoemulsifying oral drug delivery system (SNEDDS) for the poorly water-soluble trans-Cinnamic acid (t-CA SNEDDS) that could be evaluated for its antihyperglycemic efficacy in comparison to the parent t-CA in an alloxan-induced diabetic rat model. A SNEDDS formulation consisting of 60% surfactant (Kolliphor EL), 10% co-surfactant (PEG 400) and 30% oil (isopropyl myristate) proved to be optimal. t-CA SNEDDS (80 mg/kg, p.o.), t-CA suspension (80 mg/kg, p.o.), and Metformin Hydrochloride Tablets (230 mg/kg, p.o.) were administer qdfor 30 days to diabetic rats. After treatment the body weight of diabetic rats was increased, blood glucose levels, total cholesterol, and triglyceride in the serum tended to be normalized, while the levels of alanine aminotransferase and aspartate aminotransferase were markedly decreased. The effects of t-CA SNEDDS were superior to that of the t-CA suspension. The present study demonstrated that t-CA was effective in attenuating the effects of alloxan treatment and that t-CA SNEDDS with a more favorable absorption and enhanced bioavailability is more effective than t-CA.

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Section: Discussionsupporting

confidence: 91%

Self‐Nanoemulsifying Drug Delivery System of trans‐Cinnamic acid: Formulation Development and Pharmacodynamic Evaluation in Alloxan‐induced Type 2 Diabetic Rat Model

Wang

Deng

et al. 2015

Drug Development Research

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“…Atriplex halimus, commonly known as salt bush, is a plant endemic to Israel; its aqueous leaf extract has demonstrated to reduce blood and liver glucose levels [129]. In vivo studies performed with diabetic rats (sand rats) revealed the T2DM onset in the absence of the A. hamilus [130].…”

Section: Atriplex Halimus (Salt Bush)mentioning

confidence: 99%

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

et al. 2019

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Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.

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“…It is a monoecious plant that is pollinated by wind and produces a staminate flower [3]. It is widely distributed in Europe and Northern Africa, including the Sahara in Morocco and Algeria [4] (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…In Algeria and in particular, the Sahara part, the plant is used by Bedouin for feeding their sheep and goats [4], and in popular folk remedy, it is used to treat diabetes, stomach pains, chest ailments, muscular pain, and intestinal worms and to regulate gallbladder excretions.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Gas Chromatography–mass Spectrometry Studies of Algerian Atriplex Halimus L.

Ziane

Djellouli

Miloudi

2020

Asian J Pharm Clin Res

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Objective: The objective of the study was to find out the antibacterial efficacy and identify the main constituents of the essential oil of Atriplex halimus from southwest of Algeria. Methods: The essential oil from the aerial parts of the endemic plant A. halimus (saltbush in English, qataf in Arabic) collected from the region of Sahara southwest of Algeria was isolated by hydrodistillation and analyzed by gas chromatography–mass spectrometry. Antibacterial potency of essential oil from this plant has been tested against Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), and Bacillus cereus (ATCC11778) by disk diffusion assay. Results: The essential oil revealed the presence of 14 components, the dominant compounds arecadina-1(10), 4-diene (10.69%), germacrene D (9.79%), octane (9.37%), pelargonaldehyde (9.06%), 3-Furancarboxaldehyde (6.87%), β-pinene (2.6%), camphene (2.59%), and myrcene (2.10%). The essential oil exhibits very effective antimicrobial activity using disk diffusion assay method with minimum inhibitory concentration ranging from 0.82 μl/ml to 2.4525 μl/ml. Conclusions: This result showed that this native plant may be a good candidate for further biological and pharmacological investigations.

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Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin–induced diabetic rats

Cited by 69 publications

References 13 publications

Self‐Nanoemulsifying Drug Delivery System of trans‐Cinnamic acid: Formulation Development and Pharmacodynamic Evaluation in Alloxan‐induced Type 2 Diabetic Rat Model

Self‐Nanoemulsifying Drug Delivery System of trans‐Cinnamic acid: Formulation Development and Pharmacodynamic Evaluation in Alloxan‐induced Type 2 Diabetic Rat Model

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Antibacterial Activity and Gas Chromatography–mass Spectrometry Studies of Algerian Atriplex Halimus L.

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