Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts

Jani, Deepti Kaushalkumar; Goswami, Sumanta

doi:10.1016/j.jtcme.2019.03.002

Cited by 23 publications

(12 citation statements)

References 33 publications

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“…Aminoglycosides (especially sennoside A and B) in senna have been reported to have antihyperglycemic activity [13,34]. The aqueous extract of senna improves metabolic abnormalities linked with diabetes and reduces chronic hyperglycemia-related complications in streptozotocin-induced diabetic rats [17,35]. In our experiment, glucose utilization was improved by S. alexandrina leaf powder supplementation, which is supported by a previous study [36].…”

Section: Discussionsupporting

confidence: 85%

Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

et al. 2021

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Obesity is an enduring medical issue that has raised concerns around the world. Natural plant extracts have shown therapeutic potential in preventing oxidative stress and inflammation related to obesity complications. In this study, Senna alexandrina Mill. leaves were utilized to treat high-fat diet-related metabolic disorders and non-alcoholic fatty liver diseases. Plasma biochemical assays were conducted to determine the lipid profiles and oxidative stress parameters, and the gene expression of antioxidant enzymes and inflammatory mediators was measured. Histological stained livers of high-fat diet-fed rats were observed. S. alexandrina leaf powder supplementation prevented the increase in cholesterol and triglyceride levels in high-fat diet-fed rats. Moreover, S. alexandrina leaves also reduced lipid peroxidation and nitric oxide production in these rats. Prevention of oxidative stress by S. alexandrina leaf supplementation in high-fat diet-fed rats is regulated by enhancing the antioxidant enzyme activity, followed by the restoration of corresponding gene expressions, such as NRF-2, HO-1, SOD, and CAT. Histological staining provides further evidence that S. alexandrina leaf supplementation prevents inflammatory cell infiltration, lipid droplet deposition, and fibrosis in the liver of high-fat diet-fed rats. Furthermore, this investigation revealed that S. alexandrina leaf supplementation controlled non-alcoholic fatty liver disease by modulating the expression of fat metabolizing enzymes in high-fat diet-fed rats. Therefore, S. alexandrina leaf supplementation inhibits fatty liver inflammation and fibrosis, suggesting its usefulness in treating non-alcoholic steatohepatitis. Thus, this natural leaf extract has potential in treatment of obesity related liver dysfunction.

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Section: Discussionsupporting

confidence: 85%

Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

et al. 2021

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“…Furthermore, in silico studies revealed that compounds, such as rutin [ 42 ] and isorhamnetin [ 43 ] effectively inhibited the tyrosinase enzyme. The results of α- amylase and α-glucosidase inhibition might explain, in part, and support previous in vivo studies on the antidiabetic activity of the leaves of C. fistula [ 44 ] and S. alexandrina [ 45 ], as well as an in vitro study on the S. italica leaf [ 46 ]. In addition, the inhibition effect of the leaf of C. grandis shown in the present study, as well as previous in vivo studies demonstrating the hypoglycemic effect of the stem bark [ 16 ] and fruit pulp [ 37 ], suggest that all parts of this plant merit an in depth investigation on its antidiabetic activity.…”

Section: Resultssupporting

confidence: 87%

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

et al. 2022

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Several species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic content and antioxidant and enzyme inhibition activities of leaf methanolic extracts of C. fistula L., C. grandis L., S. alexandrina Mill., and S. italica Mill. The two Cassia spp. contained higher total polyphenolic content (42.23–49.75 mg GAE/g) than the two Senna spp., and C. fistula had significantly (p ˂ 0.05) the highest concentration. On the other hand, the Senna spp. showed higher total flavonoid content (41.47–59.24 mg rutin equivalent per g of extract) than that found in the two Cassia spp., and S. alexandrina significantly (p ˂ 0.05) accumulated the highest amount. HPLC–MS/MS analysis of 38 selected bioactive compounds showed that the majority of compounds were identified in the four species, but with sharp variations in their concentrations. C. fistula was dominated by epicatechin (8928.75 µg/g), C. grandis by kaempferol-3-glucoside (47,360.04 µg/g), while rutin was the major compound in S. italica (17,285.02 µg/g) and S. alexandrina (6381.85). The methanolic extracts of the two Cassia species exerted significantly (p ˂ 0.05) higher antiradical activity, metal reducing capacity, and total antioxidant activity than that recorded from the two Senna species’ methanolic extracts, and C. fistula displayed significantly (p ˂ 0.05) the highest values. C. grandis significantly (p ˂ 0.05) exhibited the highest metal chelating power. The results of the enzyme inhibition activity showed that the four species possessed anti-AChE activity, and the highest value, but not significantly (p ≥ 0.05) different from those obtained by the two Cassia spp., was exerted by S. alexandrina. The Cassia spp. exhibited significantly (p ˂ 0.05) higher anti-BChE and anti-Tyr properties than the Senna spp., and C. grandise revealed significantly (p ˂ 0.05) the highest values. C. grandise revealed significantly (p ˂ 0.05) the highest α- amylase inhibition, while the four species had more or less the same effect against the α-glucosidase enzyme. Multivariate analysis and in silico studies showed that many of the identified phenols may play key roles as antioxidant and enzyme inhibitory properties. Thus, these Cassia and Senna species could be a promising source of natural bioactive agents with beneficial effects for human health.

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“…Earlier findings also suggested that, synergistic effects of bioactive compounds such as flavonoids, saponins and glycosides are responsible for beneficial effect in diabetes. 54 Additionally, previous findings suggested that Rutin showed prominent antidiabetic potential in STZ induced diabetes via different mechanisms. 55 , 56 Furthermore, the fractionation of extract results in increase degree of polymerization and segregation of phytoconstituents such as steroids, complex polyphenols and increases degree of polymerization.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of pancreatic regeneration activity of Tephrosia purpurea leaves in rats with streptozotocin-induced diabetes

Arora

Verma

Itankar

et al. 2021

Journal of Traditional and Complementary Medicine

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Background and aim Flavonoid rich plant Tephrosia purpurea ( T. purpurea ), commonly known as Sarpunkha has been used in traditional systems of medicine to treat diabetes mellitus. However, its effectiveness in promoting regeneration of pancreas in diabetes has not been investigated. Therefore, the present study was undertaken to evaluate pancreatic β-cells regeneration, antioxidant and antihyperlipidemic potentials of T. purpurea leaves extract, its fractions and main constituent Rutin in diabetic rats. Experimental procedure The leaves extract and its fractions were first screened for acute and sub-chronic antidiabetic activity in a dose range of 250–500 mg/kg orally. Further, fractions with potent antidiabetic activity were screened for pancreatic β-cells regeneration activity using histopathological studies and morphometric analysis, which was followed by estimation of biochemical parameters. Results and conclusion The most significant antidiabetic, pancreatic regeneration and antihyperlipidemic activity was exhibited by n -butanol soluble fraction of ethanol extract at the dose level of 500 mg/kg. Histopathology revealed that treatment with this fraction improved the β-cell granulation of islets and prevented the β-cells damage which was further confirmed by morphometric analysis. Thus, the present study validated the traditional use of T. purpurea plant in the treatment of diabetes, which might be attributed to pancreatic β-cells regeneration potential of its active constituent Rutin. Taxonomy (classification by EVISE) Traditional Medicine; Metabolic Disorder; Experimental Design; Cell Regeneration and Histopathology.

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Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts

Cited by 23 publications

References 33 publications

Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

Evaluation of pancreatic regeneration activity of Tephrosia purpurea leaves in rats with streptozotocin-induced diabetes

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