Antidiabetic Activity of Isolated Compound from Coccinia indica

Jamwal, Anupam; Kumar, Suresh

doi:10.5530/ijper.53.1.20

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…The mild and chronic elevation of aminotransferases is a marker of hepatic insulin resistance. The builds levels of ALT and SGOT are a clinical component of metabolic syndrome in type 2 diabetic (Jamwal and Kumar, 2019). In the present investigation, modi ication in hepatic marker catalysts is adjusted with builds levels of aminotransferases in diabetic rats.…”

Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 74%

“…Serum alanine amino transaminase (ALT) were dictated by IFCC strategy utilizing commercial pack (Coral/clinical System, India) (Jamwal and Kumar, 2019). The absorbance of standard and test against reagent blank was estimated at 540 nm.…”

Section: Measurement Of Serum Alanine Amino Transaminase (Alt)mentioning

confidence: 99%

“…In diabetes mellitus because of different metabolic confusions and advancement of insulin obstruction may animate lipolysis in the fat tissue and offer ascent to hyperlipidemia. Hence, diabetes hyperlipidemia happens and which is related to cardiovascular danger (Jamwal and Kumar, 2019;Suman et al, 2013). Figure 4 uncover the chloroform and methanol concentrate of Barleria cuspidata consequences for serum lipid levels in control and experimental groups.…”

Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 99%

“…The liver has a conspicuous function in the metabolism of insulin and upkeep of glucose homeostasis in fasting and non-fasting conditions. Liver dysfunction results in hepatic insulin resistance and causes progression in diabetes (Jamwal and Kumar, 2019). Aminotransferases, for example, SGOT, SGPT, ALP and ALT are the common hepatic marker compounds are referred to re lects in hepatocellular necrosis as they are delivered into the blood course after cell membrane damage (Bhatia and Jain, 2003).…”

Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 99%

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Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

Reddy¹,

Sundararajan

2021

ijrps

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Traditionally, Barleria cuspidata Heyne ex Nees is utilized for antidiabetic action with the absence of logical investigation. Thus, the current examination was attempted to explore for its antidiabetic and antihyperlipidemic movement in streptozotocin instigated diabetic animal models. Blood glucose levels were estimated in normoglycemic rats at initial, 60th and 120th minutes intervals and in glucose feed hyperglycemic rats at initial, 30, 60, 90 and 120 minutes after a solitary portion of streptozotocin at 55 mg/kg body weight intraperitoneal were made diabetic in albino rats. Blood glucose levels were estimated at week by week spans after everyday administration of chloroform and methanol extracts of Barleria cuspidata at dosages of 250 and 500 mg/kg body weight. Other biochemical boundaries of serum triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total protein, albumin, globulin, uric acid, creatinine, urea, transaminases, alkaline phosphatase, alanine aminotransaminase, insulin and glycosylated hemoglobin were likewise estimated toward the finish of the investigation. Chloroform and methanol extracts of Barleria cuspidata by an oral organization for 21 days altogether (P<0.001) decreases the elevated blood glucose extents in diabetic rats whereas in normoglycemic rats it doesn't adjust the blood glucose amounts altogether and in glucose feed hyperglycemic rats significantly decreases the raised blood glucose levels. Likewise, the chloroform and methanol extracts of Barleria cuspidata improved other biochemical boundaries related to diabetes. Moreover, the extracts of Barleria cuspidata favourable affect the histopathological changes of pancreas in streptozotocin initiated diabetic rats. Delayed consequences legitimize the traditional utilization of Barleria cuspidata for its anti-diabetic action.

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Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 74%

Section: Measurement Of Serum Alanine Amino Transaminase (Alt)mentioning

confidence: 99%

Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 99%

Section: Figure 1: Effectof Cebc and Mebc Treatment On Blood Glucose Level In Normoglycemic Ratsmentioning

confidence: 99%

See 2 more Smart Citations

Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

Reddy¹,

Sundararajan

2021

ijrps

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“…Rats of all these groups received glucose (2g/kg) orally. Blood samples were collected puncturing retro-orbital plexes before drug administration at 0.5, 1, and 2 h (after glucose administration) for blood glucose determination 9 .…”

Section: Effect On Glucose Loaded Normal Ratsmentioning

confidence: 99%

Untitled

2020

IJPSR

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Polyherbal formulation (HF) containing different herbs have been used to treat diabetic patients by ayurvedic practitioners in India. The present study reports the effect of HF alone and with metformin on different rat models of hyperglycemia. HF treatment with HF alone and in combination with metformin elicited a significant hypoglycemic effect on epinephrine hyperglycemia and alloxan diabetic rats. HF treatment also altered the glucose-tolerance curve pattern both in normal and diabetic rats. Further, HF treatment alone and with metformin increased liver glycogen, glucose transfer in the liver, enhanced glucose uptake process in peripheral muscles, and also improved architecture of β-islets of Langerhans of diabetic rats. The combination of HF with metformin elicited a greater degree of hypoglycemic activity, which was reflected both on blood glucose level as well as other biochemical parameters studied. The hypoglycemic effect of HF may be mediated through pancreatic as well as extrapancreatic systems. Further, HF combination with metformin seems to be useful in diabetes mellitus and needs to be investigated on human subjects to establish such potentiation hypoglycemic effect of metformin. INTRODUCTION: Diabetes mellitus (DM) is a group of metabolic disorders characterized by abnormalities in carbohydrate and lipid metabolism 1 , which leads to hyperglycemia, hypertriglyceridemia and hypercholesterolemia resulting from defects in insulin secretion or action or both 2. The disease is managed clinically with insulin and oral hypoglycemic agents like sulphonylureas and biguanides. The biguanide phenformin was withdrawn from US market in 1997 following reports of the relatively high incidence of lactoacidosis 3 and later replaced by metformin.

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Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review

Gaonkar

Hullatti

2020

J Diabetes Metab Disord

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Objective The present review aims to provide an overview of traditional medicinal plants known to be of anti-diabetic potential. Methods A literature search was conducted using the scientific databases including PubMed, EMBASE and google scholar and a total of fifty herbs have been described and their possible mechanism of anti-diabetic action has been mentioned. Among them, in-depth discussion on five most potent anti-diabetic herbs has been provided with respect to their mechanism of action, in-vivo studies and clinical efficacies. ResultsThe present review has highlighted the usefulness of the herbal source for the treatment and management of diabetes mellitus. With the help of previous literature published on In-vivo animal studies and human clinical studies; the effectiveness of Gymnema sylvestre, Momordica charantia, Trigonella foenum graecum, Tinospora cordifolia and Curcuma longa in the treatment and management of Diabetes has been proved. Conclusion Based on this review it can be concluded that herbs can serve as more efficient, safer, and cost-effective adjuvant therapy in the management and treatment of diabetes. Further investigations mainly focusing on the isolation of phytocompounds from these herbs can lead to the discovery of newer antidiabetic agents.

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Antidiabetic Activity of Isolated Compound from Coccinia indica

Cited by 13 publications

References 40 publications

Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

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Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review

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