Antidiabetic Activity Of &lt;i&gt;Cassia auriculata&lt;/i&gt; Seeds In Alloxan Induced Diabetic Rats

Jalalpure, S. S.; Patil, M. B.; Pai, Aruna; Shah, B. N.; Salahuddin,

doi:10.4314/njnpm.v8i1.11807

Cited by 14 publications

(10 citation statements)

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“…Cassia auriculata Seed, leaf, flower Has anti hyperglycemic activity in alloxan [46], [47] and reduces blood sugar level in Streptozotocin diabetic [48] rats. Flavonoids and phenolic acids [49] have antidiabetic activity [50] 22…”

Section: Cassia Alatamentioning

confidence: 99%

“…Phenolic components (marsupsin and pterostilbene) significantly lowered the blood glucose level of hyperglycemic rats [88]. 46 Pterocarpus santalinus Seed, wood, bark Epicatechin [89] and pterostilbene [90] have antidiabetic activity 47 Pueraria lobata Root, Flower Puerarin, [91] an isoflavone, has been associated with lowering of blood glucose; Tectorigenin and kaikasaponin III alleviate STZ-induced toxicity and have hypoglycemic activity in rats [92], [93] 48 Securigera securidacea Seed Extract containing flavonoids reduces blood glucose levels in alloxan-treated mice [94] and rats [95] 49…”

Section: Pterocarpus Marsupiummentioning

confidence: 99%

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Antidiabetic Potential of Fabaceae Family: An Overview

Rathee¹,

Chaudhary²,

Rathee³

et al. 2010

CNF

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Diabetes mellitus is a global metabolic epidemic affecting essential biochemical activities in almost every age group. Over the last century changes in human behavior and lifestyle have resulted in a dramatic increase in the incidence of diabetes world over. Traditional medicinal plants and herbs having potential anti-diabetic activity are being used as part of diet since prehistoric time. Scientific data on a number of medicinal plants have proved remarkable for cure of diabetes and its complications. The current paper is aimed at providing an overview of the most effective hypoglycemic plants and herbs of Fabaceae Family along with the safety profile of the species used.

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Section: Cassia Alatamentioning

confidence: 99%

Section: Pterocarpus Marsupiummentioning

confidence: 99%

Antidiabetic Potential of Fabaceae Family: An Overview

Rathee¹,

Chaudhary²,

Rathee³

et al. 2010

CNF

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“…This diverse genera include Senna alexandrina and Cassia angustifolia. It exhibits anti-inflammatory, antioxidant, antimutagenic (Ahmed et al, 2018), hypoglycemic (Jalalpure, Patil, Pai, Shah, & Salahuddin, 2004), antiplasmodial, larvicidal (Yang, Lim, & Lee, 2003), and anticancer activities (Prasanna, Harish, Pichai, Sakthisekaran, & Gunasekaran, 2009). Its leaves and fruits contain several laxative compounds such as calcium sennosides A and B (Figure 1), aloe-emodin, fatty oils, flavonoids, polysaccharides, and tannins (Franz, 1993).…”

Section: Introductionmentioning

confidence: 99%

Synergetic role of senna and fennel extracts as antioxidant, anti-inflammatory and anti-mutagenic agents in irradiated human blood lymphocyte cultures

Farid

Kamel

Montaser

et al. 2020

Journal of Radiation Research and Applied Sciences

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2020) Synergetic role of senna and fennel extracts as antioxidant, anti-inflammatory and anti-mutagenic agents in irradiated human blood lymphocyte cultures, ABSTRACT Present work aimed to examine antioxidant, anti-inflammatory and anti-mutagenic effects of senna and fennel via synergetic mechanisms against deleterious effects of gamma radiation exposure. Cytogenetic, biochemical and immunological investigations were evaluated in human blood lymphocyte cultures. Samples were divided into Group I: control, Group II: irradiated samples with 3Gy γ-irradiation, Group III: treated samples with a mixture of calcium sennosides and fennel seed extract and Group IV: irradiated treated samples. The results revealed that radiation exposure caused an increment in numbers of micronuclei (MN), nucleoplasmic bridges (NPBs), mono-, and multinucleated cells. Biochemical results revealed a decrease in levels of SOD and CAT enzymes and an increase in LDH level after irradiation. Levels of cytokines (IL-1β, IL-6, IL-8, and TNF-α) were significantly increased in irradiated group. Calcium sennosides and fennel seed extract mixture treatment after radiation exposure succeeded in returning cytokines and antioxidant enzyme levels to their normal levels as compared to control. Also, group IV showed a marvelous improvement in numbers of MN and NPB frequencies. These results indicate that the combination between Calcium sennosides as free radicals scavenger and fennel as an apoptic inducer can be used as a post-radiation treatment against oxidative and inflammation effects of ionizing radiation. ARTICLE HISTORY

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“…The leaves of the plant have been reported to contain pharmacologically bioactive substances. Studies have shown that this plant possesses anti-inflammatory (Chidume et al, 2001), antioxidant (Kumaran and Karunakaran, 2007), hypoglycaemic (Jalalpure et al, 2004), and anticancer activities (Yadav et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory activity of fractions of Senna nigricans toward protein tyrosine phosphatase 1B and dipeptidyl peptidase IV

Saidu¹,

Muhammad²,

Bilbis³

et al. 2016

J. Med. Plants Res.

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Protein tyrosine phosphatase (PTP) 1B and dipeptidyl peptidase (DPP) IV are important in down regulation and secretion of insulin, respectively. While PTP 1B regulates insulin binding to its receptor, DPP IV hydrolyses incretin, which is an important regulator of postprandial insulin secretion. The study evaluated the in vitro inhibitory effect of different fractions of Senna nigricans against PTP IB and DPP IV and the results were compared with standard inhibitors, sumarin and P32/98. The methanolic extract was further fractionated using Soxhlet apparatus and then the most potent fraction eluted through column on silica gel. The result indicated that the methanolic fraction had the highest inhibition percentage of 56.43±3.98 against PTP 1B. The inhibition of PTP 1B by methanolic fraction was significantly (P<0.05) higher than that of the standard inhibitor, sumarin. The PTP 1B inhibition by ethyl acetate fraction (31.34±5.40%) was not significantly (P>0.05) different from that of sumarin, while hexane fraction had the inhibition of 19.03±4.24% which was significantly (P<0.05) decreased as compared with sumarin. The result of DPP IV inhibition indicated that the methanolic, hexane and ethyl acetate fractions were not significantly different, but all the fractions were significantly less active than the standard inhibitor, P32/98 which recorded 63.1±4.67% inhibition of DPP IV. Because of S. nigricans as sources of PTP 1B inhibitors most especially and to some extent DPP IV inhibitors, the plant may be a potential source for the discovery of lead compounds as PTP 1B and DPP IV inhibitors to treat type 2 diabetes mellitus.

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Antidiabetic Activity Of <i>Cassia auriculata</i> Seeds In Alloxan Induced Diabetic Rats

Cited by 14 publications

References 0 publications

Antidiabetic Potential of Fabaceae Family: An Overview

Antidiabetic Potential of Fabaceae Family: An Overview

Synergetic role of senna and fennel extracts as antioxidant, anti-inflammatory and anti-mutagenic agents in irradiated human blood lymphocyte cultures

Inhibitory activity of fractions of Senna nigricans toward protein tyrosine phosphatase 1B and dipeptidyl peptidase IV

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