Antidiabetic activity of standardized dried tubers extract of Aconitum napellus in streptozotocin‐induced diabetic rats

Abstract

India has got rich cultural inheritage in the forms of Ayurveda texts which are a rich and ample source of herbs, shrubs, trees and affluent in medicinally active phytoconstituents. Aconitum napellus is used for the cure of many ailments including rheumatoid arthritis, sciatica and gout. The present work attempts to evaluate the physicochemical and preliminary phytochemical studies on the tubers of Aconitum napellus along with its antidiabetic activity. The herbal standardization was carried out on the basis of organoleptic properties, physical characteristics and physicochemical properties. The body weight of ACON-I (1.25 mg/kg) and ACON-II (2.5 mg/kg) was recorded as 190.40 and 209.40 g, respectively, compared with 163.00 g in diabetic rats at day 28. The body weight of ACON-I and ACON-II was significantly increased compared with diabetic rats (p < 0.01). However, the body weight of ACON-I and ACON-II was decreased significantly (p < 0.01) compared with normal group (222.60 g). The blood glucose levels of diabetic rats and ACON-I group were recorded as 277.800 and 152.400 mg/dl, respectively, compared with 83.600 mg/dl in normal rats (p < 0.01). However, the HbA1c levels of diabetic rats and ACON-I group were recorded as 11.306 and 6.936% Hb, respectively, compared with 4.539% Hb in normal rats. The glucose and HbA1c levels of diabetic and ACON-I groups were significant compared with normal group (p < 0.01). The results of antidiabetic activity showed that the plant can be used as a potent source for the treatment of diabetes and its complications. The results of this work provided the referential information for the identification and standardization of Aconitum napellus along with its role as a hypoglycemic agent.

RETRACTED ARTICLE: Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies

“…However, effective and safe treatment in curing diabetes is yet to be achieved. Therefore, there is a need to explore the phytochemical as they are considered less toxic than synthetic medicines and help manage type 2 DM (Shoaib et al 2020;Choudhary et al 2020;Eitah et al 2019;Simon et al 2018). The plant Operculina turpethum (L.) Silva Manso (Convolvulaceae) methanolic and aqueous extracts were earlier reported to have antidiabetic activity (Pulipaka et al 2012;Gupta and Ved 2017).…”

Assessment of Antidiabetic Activity of the Shikonin by Allosteric Inhibition of Protein-Tyrosine Phosphatase 1B (PTP1B) Using State of Art: An In Silico and In Vitro Tactics

“…Diabetes mellitus (DM) can be described as a multi metabolic dysfunction ascribable to either absolute or relative insulin deficiency leading to hyperglycemia [ 1 ]. Specialists have prognosticated that incidence may accumulate to approximately 64% by 2025 and may target 53.1 million people [ 2 ].…”

Neuroprotective Effects of Dried Tubers of Aconitum napellus

“…Detoxification of the tubers was done using either water, or cow or goat milk according to the traditional Ayurvedic method i.e., shodhana samaskara [18,19] and extraction was performed using chloroform as per our previous study [12]. Different solvents e.g., n-hexane, chloroform, methanol and water were used for extraction and chloroform extract was found to contains maximum percentage yield hence was used for further investigation [20].…”