Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats

Rao, B Kameswara; Sudarshan, P. Renuka; Rajasekhar, Maddirala Dilip; Nagaraju, N.; Rao, Ch. Appa

doi:10.1016/s0378-8741(02)00396-3

Cited by 83 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, several hundred plants have been reported to have beneficial effects for the treatment of diabetes mellitus, and we have several reports in this line [10–12] as well as of others [13–15]. Research on phytomolecules as diabetic remedies is upraising gradually as these are with minimal or no side effects [16–18]. Swietenia mahagoni ( S. mahagoni ), is under family Meliaceae, beautiful, lofty, evergreen, large native tree of tropical America, Mexico, South America, and India.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Potentiality of the Aqueous‐Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin‐Induced Diabetic Male Albino Rat: A Correlative and Evidence‐Based Approach with Antioxidative and Antihyperlipidemic Activities

Chatterjee

Ali

et al. 2010

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water−1100 gm b.w.−1rat−1 day−1) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Antidiabetic Potentiality of the Aqueous‐Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin‐Induced Diabetic Male Albino Rat: A Correlative and Evidence‐Based Approach with Antioxidative and Antihyperlipidemic Activities

Chatterjee

Ali

et al. 2010

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…TP fruit's ethanolic extract (TPEt) possess significant anti-ulcer and antihyperglycemic activities. [67]…”

mentioning

confidence: 99%

Antihyperlipidemic and antiatherogenic activities of Terminalia pallida Linn. fruits in high fat diet-induced hyperlipidemic rats

et al. 2011

View full text Add to dashboard Cite

Hyperlipidemia contributes significantly in the manifestation and development of atherosclerosis and coronary heart disease (CHD). Although synthetic lipid-lowering drugs are useful in treating hyperlipidemia, there are number of adverse effects. So the current interest has stimulated the search for new lipid-lowering agents with minimal side effects from natural sources. The present study was designed to investigate the antihyperlipidemic and antiatherogenic potentiality of ethanolic extract of Terminalia pallida fruits in high fat diet-induced hyperlipidemic rats. T. pallida fruits ethanolic extract (TPEt) was prepared using Soxhlet apparatus. Sprague-Dawley male rats were made hyperlipidemic by giving high fat diet, supplied by NIN (National Institute of Nutrition), Hyderabad, India. TPEt was administered in a dose of 100 mg/kg.b.w./day for 30 days in high fat diet-induced hyperlipidemic rats. The body weights, plasma lipid, and lipoprotein levels were measured before and after the treatment. TPEt showed significant antihyperlipidemic and antiatherogenic activities as evidenced by significant decrease in plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels coupled together with elevation of high-density lipoprotein cholesterol levels and diminution of atherogenic index in high fat diet-induced hyperlipidemic rats. There was a significantly reduced body weight gain in TPEt-treated hyperlipidemic rats than in the control group. The present study demonstrates that TPEt possesses significant antihyperlipidemic and antiatherogenic properties, thus suggesting its beneficial effect in the treatment of cardiovascular diseases.

show abstract

“…Flavonoids are known to have bioactive antidiabetic principles. [20] Flavonoid glycoside is assumed to be the compound responsible for the lowering of glucose.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect ofLeucas lavandulaefoliawilld in alloxan-induced diabetic rats

Ks¹,

Prasanna²

2009

J Young Pharmacists

View full text Add to dashboard Cite

Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats

Cited by 83 publications

References 12 publications

Antidiabetic Potentiality of the Aqueous‐Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin‐Induced Diabetic Male Albino Rat: A Correlative and Evidence‐Based Approach with Antioxidative and Antihyperlipidemic Activities

Antidiabetic Potentiality of the Aqueous‐Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin‐Induced Diabetic Male Albino Rat: A Correlative and Evidence‐Based Approach with Antioxidative and Antihyperlipidemic Activities

Antihyperlipidemic and antiatherogenic activities of Terminalia pallida Linn. fruits in high fat diet-induced hyperlipidemic rats

Hypoglycemic effect ofLeucas lavandulaefoliawilld in alloxan-induced diabetic rats

Contact Info

Product

Resources

About