Antidiabetic Activity Test of Ethanolic Seri Leave’s (Muntingia Calabura L.) Extract in Male Rats Induced by Alloxan

Abstract

Antidiabetic activity test of ethanol extract of seri leave (Muntingia calabura L.) rats induced by alloxan has been done. Male wistar albino rats are used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Na CMC 0,5%), positive control group (glibenclamide0,43 mg/200 g of BW), and 1, 2, and 3 treatment groups (ethanol extract of seri leave 65, 130, dan 260 mg/kg of BW). Rats blood glucose level after induced intraperitoneally by alloxan130 mg/kg of BWcan be stated as diabetes when >200 mg/dL. Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 5, 10, and 15. The average result of AUC 0-15 and percentage of decreasing blood glucose level for positive control group are 2732,5 and 37,43%, and 3 treatment groups (65 mg/kg of BW, 130 mg/kg of BW, and 260 mg/kg of BW) 3105 and 28.90%; 2962.5and 32.16%; 2810 and 35.66%. These points indicated that the ethanol extract of seri leave have an antidiabetic activity and there is no significant difference compared with glibenclamide (p<0.05). Percentage of blood glucose decrease level the third treatment group so there is no significant difference compared with positive control group. According to the relation between percentages of blood glucose decrease level with dose, value of ED 50 of ethanol extract of seri leave is 692.424 mg/kg of BW.

Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice

“…Substance screening from M. calabura leaves showed alkaloid, flavonoid, tannin, saponin, triterpenoid, and steroid 13,14 Several previous studies stated that M. calabura leaf has potential as an antidiabetic drug, including a study by Zulham, Hendrarti, and Wahyuni (2019) 15 who showed that ethanol extract from M. calabura leaves with 50, 100, and 150 mg/kg obtained from macemiceion could reduce blood glucose level in alloxan-induced diabetic mice. The results from Herlina, Amriani, Solihah, and Sintya (2018) 16 also showed that ethanol extract from M. calabura leaves with 65, 130, and 260 mg/kg could reduce blood glucose levels to 28.90%, 32.16%, and 35.66% in male albino mice induced by alloxan.…”

Mekanisme Aktivitas Anti-Diabetes Dari Kandungan Senyawa Tanaman Kersen (Muntingia calabura L.): Systematic Review

“…Pada sebuah penelitian, dengan pemberian ekstrak air daun kersen pada hewan coba yang mengalami resistensi insulin dengan dosis 400 mg/kg BB dapat meningkatkan sensitivitas insulin, hal tersebut dibuktikan dari peningkatan nilai KITT yang serupa dengan kelompok yang diberikan glibenklamid [9]. Peningkatan nilai KITT disebabkan oleh kandungan flavonoid pada daun kersen yang dapat meningkatkan sensitivitas insulin dan mencegah kerusakan sel beta pankreas yang berfungsi untuk menghasilkan insulin [29].…”

Studi Etnobotani Tumbuhan Obat di Desa Kutalanggeng dan Kutamaneuh Kecamatan Tegalwaru Kabupaten Karawang Jawa Barat

“…Sirih (Piper betle) mengandung minyak atsiri yang efektif menghambat pertumbuhan Candida albicans (19) . Kersen (Muntingia calabura L) digunakan untuk menurunkan dula darah, hasil penelitian menunjukkan penurunan kadar dengan ED50 692.424 mg/kg (20) . Binahong (Anredera cordifolia Ten.)…”

“…Majalah Farmasetika menerima karya ilmiah di bidang farmasetika di alamat http://jurnal.unpad.ac.id/farmasetika/.N. S. Gunarti, Majalah Farmasetika, 6 (1) 2021,[14][15][16][17][18][19][20][21][22][23]…”