Antidiabetic and Antihyperlipidemic Activities of Methanolic Leaf Extract of <i>Stephania japonica</i> in Alloxan Induced Diabetic Rats

Abstract

This present study was aimed to investigate the antidiabetic and antihyperlipidemic activities of methanolic leaf extract (LE) of Stephania japonica alone and in combination with metformin in alloxan induced diabetic rats. Primarily acute toxicity study and oral glucose tolerance test were performed. Diabetes was confirmed after 12 days of single intraperitoneal injection of alloxan (120 mg/kg BW) in albino male rats. Rats were divided into six groups'; normal control (Group I) and diabetic induced groups as (Group II, effect and hence could be suggested as a potential therapeutic agent for diabetic treatment.

Evaluation of Safety of Stewart’s Wood Fern (Dryopteris stewartii) and Its Anti-Hyperglycemic Potential in Alloxan-Induced Diabetic Mice

“…Moreover, during the conduction of acute oral toxicity test, body and organ weights of extract treated groups remained normal, indicating the harmless nature of D. stewartii . In compliance with the current experiment findings, other articles [ 35 , 36 ] also reported similar results in Stephania japonica and Astraeushygo metricus . However, one article documented contrasting results of Lantana camara and Dryopteris ramose based toxicity studies [ 37 , 38 , 39 , 40 , 41 ].…”

“…Before the induction of hyperglycemia, the mice were fasted overnight (had access to water). A dose of 200 mg/kg body weight freshly prepared alloxan monohydrate dissolved in 10 mL/kg body weight distilled water was injected intraperitoneally [ 35 ]. Immediately after administration of Alloxan, a standard diet was provided to animals, preventing alloxan-induced hypoglycemia due to release of insulin from pancreatic β -cells.…”

“…Blood was taken by making a small incision at end of the tail vein. Mice with 300 mg/dL blood glucose level were considered diabetic and selected for assessment of anti-hyperglycemic activity [ 35 ].…”

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“…Additionally, it's reported that Arunachal Pradesh's ethnic communities consume the fresh tuber extract of S. glandulifera for a duration of 2 to 3 weeks as a diabetes remedy 42 . Additional species within the same genus, including S. glabra, S. japonica, S. hernandifolia, and S. tetrandra, have demonstrated the ability to lower blood sugar levels in diabetic mice and rats induced with alloxan and streptozotocin [43][44][45] . In this research, both methanol and aqueous extracts from the leaves of A. acidum (Syn.…”

Synthesis and characterization of magnetic carbonaceous materials from bamboo waste and investigation of their adsorption capability for cesium ions

“…[11][12][13] The release of cesium nuclides into the water environment also resulted in soil contamination and restricted the advancement of agriculture and animal tillage. [14][15][16][17][18] Therefore, according to the regulations of the International Atomic Energy Agency, low-rate radioactive wastewaters are defined as solutions with total radioactivity below 4.0×10 6 Bq/L. 19 Various treatments were proposed to prevent the spread of radionuclides in the biosphere, especially in water environments, such as membrane separation, evaporation, adsorption, reverse osmosis, ion exchange, precipitation, and filtration.…”