Antidiabetic and Antiradical Effects of Garcinia kola Seeds in Dexamethasone-Induced Hyperglycemic Rats

Nkono, Barnabé Lucien Nkono Ya; Rouamba, Ablassé; Kinyok, McJesus; Stéphane, JeanGuy; Tcheudi, BalthazarTchouanka; Tigui, BenjaminArnaud; Dzeufiet, PaulD Djomeni; Sokeng, SélestinDongmo; Kamtchouing, Pièrre

doi:10.4103/ijabmr.ijabmr_199_22

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Dexamethasone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activity. Administered in high doses and repeatedly, dexamethasone can induce diabetes mellitus with hepatic steatosis following chronic hyperglycemia and accumulation of fat in the hepatic parenchyma [10]- [12].…”

Section: Histopathological Examination Of the Liver Kidney And Pancre...mentioning

confidence: 99%

Antihyperglycemic and antihyperlipidemic effects of Cymbopogon citratus leaves in dexamethasone-induced diabetic rats

Barnabé Lucien Nkono Ya Nkono,

Placide Yannick Amougou Noa,

Léocadie Mbella Kedi

et al. 2023

Int. J. Sci. Technol. Res. Arch

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Background: In sub-Saharan Africa, especially in Cameroon, different parts of Cymbopogon citrarus (C. citratus) are prescribed as remedies for diabetes mellitus and dyslipidemia. This study was designed to investigate the effects of hydroalcoholic extract of C. citratus (HACC) leaves in dexamethasone-induced-diabetic (Dex-db) rats. Materials and Methods: The HACC was obtained by decoction for 15 min by mixing 250 g of dry powder of the leaves of C. citratus by completing the total volume to 1L with a hydroalcoholic solution (water-ethanol, 30:70). After cooling to room temperature and filtration using Whatman No. 4 filter paper, the extract was concentrated using a rotary evaporator at 45 °C. Moderate diabetes was induced by daily subcutaneous injection of dexamethasone (5 mg/kg) once daily for 7 days. On the 8th day, the animals which have a blood glucose level greater than 120 mg/dL were selected and randomized into 5 groups of 5 animals each who received the different treatments for two weeks as follows: two negative control groups, negative normal control (NNC) and negative dexamethasone control (NDC) received only vehicle (distilled water); one positive control group received glibenclamide (5 mg/kg) and two groups received HACC at doses of 50 and 100 mg/kg respectively. On the other hand, compared to the NDC group, we observed a significant (P<0.001) dose-response after 14 days of treatment a decrease in serum concentrations of TC, LDLc, and AI, and an increase in HDLc. A highly significant decrease (P<0.001) was also observed in serum TG concentration but with a more pronounced action at the lowest dose of HACC (50 mg/kg). Results: After two weeks of administration of the HACC, we observed during the oral glucose tolerance test (OGTT) a highly significant rate of reduction in glycemia (%) at the two doses tested (50 and 100 mg/kg) compared to the NNC group (P<0.001) 2 hours after glucose load, no significant difference was observed (P>0.05). With regard to the serum lipid profile (total cholesterol (TC), HDL cholesterol (HDLc), triglycerides (TG), LDL cholesterol (LDLc) and atherogenicity index (AI)), after 14 days of administration of the various treatments, with the exception of the TC which decreased significantly (P<0.001), no significant difference (P>0.05) was observed on the other parameters in the animals having received the HACC only at the dose of 100 mg/kg compared to the NNC group. Conclusion: This finding suggests that the leaves of C. citratus have a highly significant antihyperglycemic and antihyperlipidemic activity in diabetic rats by preventing the postprandial glycemia peak and by readjusting the lipid profile, in particular by lowering serum LDL-cholesterol, triglycerides and the atherogenicity index.

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Section: Histopathological Examination Of the Liver Kidney And Pancre...mentioning

confidence: 99%

Antihyperglycemic and antihyperlipidemic effects of Cymbopogon citratus leaves in dexamethasone-induced diabetic rats

Barnabé Lucien Nkono Ya Nkono,

Placide Yannick Amougou Noa,

Léocadie Mbella Kedi

et al. 2023

Int. J. Sci. Technol. Res. Arch

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“…Garcinia kola seeds Garcinia kola (GK) is a plant found in Asia and tropical Africa and is also known commonly as bitter cola because of the bitter taste of its seeds [204]. GK stems, roots, and seeds were traditionally used to treat diabetes mellitus, liver disorders, and sickle cell disease [205,206]. GK has anti-inflammatory, antioxidant, and antimicrobial properties [207].…”

Section: Lycopenementioning

confidence: 99%

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Das,

Sakr,

Al-Huseini

et al. 2023

Plants

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There are various herbicides which were used in the agriculture industry. Atrazine (ATZ) is a chlorinated triazine herbicide that consists of a ring structure, known as the triazine ring, along with a chlorine atom and five nitrogen atoms. ATZ is a water-soluble herbicide, which makes it capable of easily infiltrating into majority of the aquatic ecosystems. There are reports of toxic effects of ATZ on different systems of the body but, unfortunately, majority of these scientific reports were documented in animals. The herbicide was reported to enter the body through various routes. The toxicity of the herbicide can cause deleterious effects on the respiratory, reproductive, endocrine, central nervous system, gastrointestinal, and urinary systems of the human body. Alarmingly, few studies in industrial workers showed ATZ exposure leading to cancer. We embarked on the present review to discuss the mechanism of action of ATZ toxicity for which there is no specific antidote or drug. Evidence-based published literature on the effective use of natural products such as lycopene, curcumin, Panax ginseng, Spirulina platensis, Fucoidans, vitamin C, soyabeans, quercetin, L-carnitine, Telfairia occidentalis, vitamin E, Garcinia kola, melatonin, selenium, Isatis indigotica, polyphenols, Acacia nilotica, and Zingiber officinale were discussed in detail. In the absence of any particular allopathic drug, the present review may open the doors for future drug design involving the natural products and their active compounds.

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Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

Okoduwa,

Mhya,

Abdulwaliyu

et al. 2024

Phytochem Rev

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Antidiabetic and Antiradical Effects of Garcinia kola Seeds in Dexamethasone-Induced Hyperglycemic Rats

Cited by 6 publications

References 35 publications

Antihyperglycemic and antihyperlipidemic effects of Cymbopogon citratus leaves in dexamethasone-induced diabetic rats

Antihyperglycemic and antihyperlipidemic effects of Cymbopogon citratus leaves in dexamethasone-induced diabetic rats

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

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