Antidiabetic, anthelmintic and antioxidation properties of novel and new phytocompounds isolated from the methanolic stem-bark of Vernonia amygdalina Delile (Asteraceae)

IfedibaluChukwu, Ejiofor; Das, Aparoop; Zaman, Kamaruz

doi:10.1016/j.sciaf.2020.e00578

Cited by 18 publications

(16 citation statements)

References 75 publications

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“…Golongan senyawa yang berperan sebagai antioksidan pada penelusuran pustaka diatas menunjukan golongan senyawa flavonoid. Menurut [9], senyawa yang memiliki aktivitas sebagai antioksidan yaitu senyawa 6 β,10 β,14 β-trimethylheptadecan-15 α-olyl-15-O-β-D-glucopyranosyl-1,5 β-olide. Flavonoid merupakan golongan senyawa preduksi yang dapat menghambat banyak reaksi oksidasi, flavonoid berpotensi sebagai antioksidan karena mampu mendonorkan atom hidrogen dari gugus hidroksi kepada senyawa radikal bebas, dengan mekanisme kerja antioksidan yaitu dengan cara mendonorkan atom hidrogen atau proton pada senyawa radikal hal ini mengakibatan senyawa radikal lebih stabil [10] Tabel 1.…”

Section: Antioksidanunclassified

Telaah Efek Farmakologi Daun Afrika (Vernonia amygdalina Del) serta Senyawa Aktif di Dalamnya

Hudan

Praticia

2022

JRF

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African leaf (Vernonia amygdalina Del.) is a plant that grows in tropical climates, one of which is in Indonesia, this plant is often planted in gardens or around housing that is used by the community as an ornamental plant and can be used as a plant that has pharmacological effects or as medicine. Medicinal plants are one of the most affordable alternatives for the community. This research method is carried out in a Systemtic Literature Review (SLR). Based on the literature search, it was found that the pharmacological effects of African leaves (Vernonia amygdalina Del.) include antioxidants with lC50 values of 371.98 ppm, 175,021 ppm, 3489,1759 ppm. anticholesterol with a concentration of 100 mg/kg BW and 200 mg/kg can reduce cholesterol levels. anticancer with lC50 N hexane, ethyl acetate (EAF) fraction, ethanol fraction 1,860.54 – 93.11 – 25.04 – 0.3 and 1,940.84 – 96.37 g/ml, anthelmintics with concentrations of 1.4% and 2.0093% can kill the worm population with a class of compounds that provide pharmacological activity namely flavonoids and antibacterials with a concentration of 0.1 mg/ml, 200 mg/ml can inhibit bacteria with an inhibition zone of 7.48 ± 0, 17 6.69 and 6.52 mm with a group of compounds that provide activity namely phenol. ABSTRAK: Daun Afrika (Vernonia amygdalina Del.) merupakan tanaman yang tumbuh pada iklim tropis salah satunya di indonesia, tanaman ini sering ditanam dikebun atau disekitar perumahan yang digunakan oleh masyarakat sebagai tanaman hias dan bisa digunakan sebagai tanaman yang memiliki efek farmakologi atau sebagai obat. Tanaman obat merupakan salah satu alternatif yang terjaukau bagi masyarakat. Metode penelitian ini dilakukan secara Systemtik Literatur Review (SLR). Berdasarkan penelusuran pustaka ditemukan efek farmakologi daun Afrika (Vernonia amygdalina Del.) meliputi Antioksidan dengan nilai lC50 sebesar 371,98 ppm, 175.021 ppm, 3489,1759 ppm, antikolesterol dengan konsetrasi 100 mg/kg BB dan 200 mg/kg dapat penurunkan kadar kolesterol, antikanker dengan nilai lC50 N heksan, fraksi etil asetat (EAF), fraksi etanol adalah 1.860,54 – 93,11 – 25,04 – 0,3dan 1,940,84 – 96,37 g/ml dan antelmintik dengan konsetrasi 1,4% dan 2,0093% dapat membunuh populasi cacing dengan golongan senyawa yang memberikan aktivitas farmakologi yaitu flavonoid serta antibakteri dengan konsentrasi 0.1 mg/ml, 200 mg/ml dapat menghambat bakteri dengan zona hambat 7,48 ± 0,17 6,69 dan 6,52 mm dengan golongan senyawa yang memberikan aktivitas yaitu fenol.

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Section: Antioksidanunclassified

Telaah Efek Farmakologi Daun Afrika (Vernonia amygdalina Del) serta Senyawa Aktif di Dalamnya

Hudan

Praticia

2022

JRF

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“…Duarte et al [ 19 ] also reported naturally occurring compounds from different plant extracts exhibiting inhibition of alpha-amylase, alpha-glucosidase, and related enzymes in the management of type II diabetes. Another study by IfedibaluChukwu et al [ 20 ] reported in vivo antidiabetic properties of isolated compounds from the methanol stem bark extract of Vernonia amygdalina using streptozotocin-induced diabetes rats. In the study, it was revealed that the isolated compound (6β, 10β, 14β-trimethylheptadecan-15α-olyl-15- O -β- d -glucopyranosyl-1,5β-olide) demonstrated a significant reduction in the blood glucose as compared to standard metformin.…”

Section: Introductionmentioning

confidence: 99%

Helichrysum Genus and Compound Activities in the Management of Diabetes Mellitus

Akinfenwa

Sagbo

Makhaba

et al. 2022

Plants

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The global management of diabetes mellitus (DM) involves the administration of recommended anti-diabetic drugs in addition to a non-sedentary lifestyle upon diagnosis. Despite the success recorded from these synthetic drugs, the traditional method of treatment using medicinal plants is increasingly accepted by the locals due to its low cost and the perceived no side effects. Helichrysum species are used in folk medicine and are documented for the treatment of DM in different regions of the world. This study reviews Helichrysum species and its compounds’ activities in the management of DM. An extensive literature search was carried out, utilizing several scientific databases, ethnobotanical books, theses, and dissertations. About twenty-two Helichrysum species were reported for the treatment of diabetes in different regions of the world. Among these Helichrysum species, only fifteen have been scientifically investigated for their antidiabetic activities, and twelve compounds were identified as bioactive constituents for diabetes. This present review study will be a useful tool for scientists and health professionals working in the field of pharmacology and therapeutics to develop potent antidiabetic drugs that are devoid of side effects.

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“…Bitter leaf (V. amygdalina) is a common homestead farming vegetable and fodder tree in sub-Sahara Africa [1,2] and has been used as an ingredient to prepare Nigerian dishes (Ogbono soup, bitter leaf soup, egusi soup, etc.) or Cameroon (Ndole) after removal of its bitter taste through washing in several changes of water or by boiling [1][2][3]. It is a unique plant (see Fig.…”

Section: Introductionmentioning

confidence: 99%

Development of a Modular Bitter Leaf Washing and Juice Extraction Machine

EBOMWONYİ

Orhorhoro

2022

Usak University Journal of Engineering Sciences

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Bitter leaf (Vernonia amygdalina) is one of the leafy vegetables that can be used to alleviate the problem of micronutrient malnutrition, prominent in tropical Africa. To ensure availability in non-growing areas, the vegetable needs to be preserved. Processing and preservation methods influence the nutrient content of the vegetables. This research work is therefore focused on the development of a modular bitter leaf washing and juice extraction machine. The machine is an electrically powered bitter leaf juice extractor that washes bitter leaf fed into it and at the same time squeezes out the juice. It uses stainless steel beaters inclined to angle of 0o to wash and squeeze the leaves against the cylindrical hopper incorporated with a perforated plate that drained juice while pulp is expelled. The beater is designed to work with the principle of oscillatory motion. The designed and fabricated bitter leaf juice washing and extraction machine was evaluated to determine the power, torque, force, etc., that are required to wash and extract the juice. The results obtained showed that the speed reduction, angular velocity, centrifugal force, torque, and power of 0.0127 m3, 480 rpm, 50.285 rad/sec, 303.430 N, 3.03 Nm, 0.75 hp are required. Also, a minimum bitter leaf extraction time of 398.28 seconds was required by the machine in comparison to manual extraction time of 724.13 seconds. Besides, the result of volume of bitter leaf juice extracted manually and mechanically from 407.54 g of bitter leaf were 3.60 litre and 3.63 litre respectively. The efficiency of the machine and the machine throughput capacity were obtained as 55.00 % and 1.032 g/sec respectively. This simply implies that the developed machine is 55.00 % efficient than manual method of washing bitter leaf.

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Antidiabetic, anthelmintic and antioxidation properties of novel and new phytocompounds isolated from the methanolic stem-bark of Vernonia amygdalina Delile (Asteraceae)

Cited by 18 publications

References 75 publications

Telaah Efek Farmakologi Daun Afrika (Vernonia amygdalina Del) serta Senyawa Aktif di Dalamnya

Telaah Efek Farmakologi Daun Afrika (Vernonia amygdalina Del) serta Senyawa Aktif di Dalamnya

Helichrysum Genus and Compound Activities in the Management of Diabetes Mellitus

Development of a Modular Bitter Leaf Washing and Juice Extraction Machine

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