Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Buchanania lanzan Spreng Methanol Leaf Extract in Streptozotocin-Induced Types I and II Diabetic Rats

Sushma, N; Smitha, P. Venkata; Gopal, Y. Venu; Vinay, R; Reddy, N. V. L Suvarchala; Mohan, Mahalaxmi; Raju, B

doi:10.4314/tjpr.v12i2.14

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…In this study, protein carbonyl, a marker of protein oxidation, was elevated in diabetic rats as supported by previous finding (Sushma et al, 2013). Nevertheless, ethanol extracts of HSE supplementation decrease the protein carbonyl level and this is in agreement with the previous study, that Roselle effectively decrease protein oxidation in renal and hepatic tissues of diabetic rats (Farombi & Ige, 2007).…”

Section: Effects Of Hpe On Oxidative Stress Status Of Thoracic Aortasupporting

confidence: 93%

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Zainalabidin¹,

Budin²,

Anuar³

et al. 2018

J App Pharm Sci

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Chronic hyperglycaemia produces excessive free radicals which could lead to diabetic complications. Hibiscus sabdariffa Linn. is proven to have high antioxidant and antihyperlipidemic properties. The aim of the study was to investigate the effects of H. sabdariffa polyphenol-rich extract (HPE) in the aorta of diabetic rats. Twenty-four male rats were randomly divided into three groups, i.e. non-diabetes mellitus (NDM), diabetes mellitus (DM) and diabetes mellitus with HPE (DM + HPE). HPE at 100 mg/kg or saline as control vehicle were administered daily through oral gavage for 28 days prior to sacrification and the aorta was isolated for further analysis. The glucose level in DM + HPE was significantly lower compared to DM, indicating its potential as an antidiabetic agent. Conversely, catalase (CAT), superoxide dismutase (SOD) activity and the level of glutathione (GSH) in DM + HPE were significantly higher than DM. The level of malondialdehyde (MDA) and protein carbonyl were significantly lower in DM + HPE than DM. Lipid profile analysis demonstrated a significant decrease in triglyceride, total cholesterol and LDL-C in DM + HPE compared to DM, however, HDL-C was significantly increased. Microscopic observation showed a disrupted morphology of the thoracic aorta in diabetic rats. HPE may exert protective effects by acting as an antidiabetic, antihyperlipidemic and antioxidant agent to the thoracic aorta in diabetic rats.

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Section: Effects Of Hpe On Oxidative Stress Status Of Thoracic Aortasupporting

confidence: 93%

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Zainalabidin¹,

Budin²,

Anuar³

et al. 2018

J App Pharm Sci

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“…In 2011, methanolic extract of leaves of Buchanania lanzan was reported to possess adaptogenic activity in an experimental study in rat model 13 . Anti-diabetic, anti-hyperlipidemic and antioxidant activity of the methanol extract of leaves of Buchanania lanzan was reported by Sushma et al, in streptozotocininduced types I and II diabetic rats 14 . As literature survey suggested the presence of variety of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids in Buchanania lanzan, a need was felt to evaluate the plant for its pharmacological activities.…”

Section: Fig 1: Buchanania Lanzan Spreng Plantmentioning

confidence: 84%

Untitled

2020

IJPSR

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The aim of this research was to perform phytochemical screening and evaluation of the pharmacological activities of Buchanania lanzan Spreng. leaves. Preliminary phytochemical screening revealed the presence of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids. Three leaf extracts were prepared by using solvents e.g. chloroform, ethyl acetate, and ethanol. The antibacterial activity was evaluated by using the paper disc method against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The chloroform extract was found to be more effective against Pseudomonas aeruginosa with a zone of inhibition 20 mm as compared to the standard antibiotic ampicillin with a zone of inhibition 20 mm. Antifungal activities were evaluated by well diffusion assay against Candida albicans, Aspergillus flavus, Aspergillus niger. The chloroform extract was found be more effective against Aspergillus flavus and Candida albicans with a zone of inhibition 22 mm and 20 mm respectively as compared to the standard antifungal ketoconazole with a zone of inhibition 22 mm. Antifungal activity against Aspergillus niger with zone of inhibition 22 mm was comparable to standard Ketoconazole with zone of inhibition 24 mm. Anthelmintic activity was performed on Pheritima posthuma using Albendazole as standard and ethanolic extract was found to be more effective. Hepatoprotective activity performed on Wistar albino rats revealed that ethyl acetate extract was more promising using LIV 52 as standard. Therefore, it can be concluded that the Buchanania Lanzan leaves specific extracts possess antimicrobial, anthelmintic and hepatoprotective activity which can be further explored for the development of formulation and their structural elucidation.

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“…These IC50 values are comparable to those of the positive controls used. Inhibitors of HSL are essential to drug targets in preventing hyperlipidemia and consequent peripheral insulin resistance [22]. Based on the results of this in vitro experiment, the triterpenes of Protorhus longifolia have inhibitory activity against pancreatic lipase and HSL.…”

Section: Pancreatic Lipase Inhibitormentioning

confidence: 96%

“…Fifteen species of the Anacardiaceae family were selected to be reviewed for their pharmacological effects on controlling the lipid profile of dyslipidemia. Those species are Anacardium occidentale [17][18][19][20][21], Buchanania lanzan Spreng [22], Lennea edulis [23], Mangifera indica [24][25][26][27][28], Pistacia atlantica [29], Pistacia khinjuk [30], Pistacia lentiscus [31][32][33], Pleiogynium timorense [34], Protorhus longifolia [35], Rhus coriaria [36][37][38][39][40], Rhus mysurensis Heyne [41], Rhus verniciflua [42], Schinus terebinthifolius [43], Semecarpus anacardium [44,45], and Spondias pinnata [46,47]. As those species are varied, their substances are different, leading to their variety of pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

A review of the pharmacological effects of Anacardiaceae family on controlling lipid profile (dyslipidemia)

Fu’adah¹,

Wilar²,

Sumiwi³

2021

J Adv Pharm Educ Res

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Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Buchanania lanzan Spreng Methanol Leaf Extract in Streptozotocin-Induced Types I and II Diabetic Rats

Cited by 12 publications

References 11 publications

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

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A review of the pharmacological effects of Anacardiaceae family on controlling lipid profile (dyslipidemia)

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