Antidiabetic, Antithrombin and Cytotoxic bioactive compounds in five cultivars of Piper betle L.

Subramaniam, Yogeswari; Bindu, K. Hima; Kamalraj, Subban; Ashokkumar, Veeramuthu; Jayabaskaran, Chelliah

doi:10.1016/j.eti.2020.101140

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…Both extracts significantly (p < 0.05) reduced the fasting blood glucose in the rats, suggesting that the extract had hypoglycemic activity [61]. The inhibition of α-glucosidase and α-amylase inhibition and the insulin-mimetic properties of Piper betle extract constitute the proposed mechanism behind the hypoglycemic effect [61], [179]. In a study conducted by Al-Adhroey et al (2010), following the OECD 423 guideline, "Acute oral toxicity-acute toxic class method", the acute toxicity of methanolic extracts from P. betel leaves was studied.…”

Section: Piper Betle Leavesmentioning

confidence: 97%

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Zanzabil,

Hossain,

Hasan

2023

Diabetology

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Plants have been used as sources of medicine since ancient times. Natural products have been used extensively in Chinese, ayurvedic and folk medicine. In addition, a significant portion of the world’s population still utilizes herbal medicine. Diabetes is a common ailment affecting almost 463 million people in the world. However, current medications exert harmful after-effects on patients, while herbal medicines have fewer adverse effects. Plants possess secondary metabolites, such as alkaloids, flavonoids, tannins, steroids, etc., which exert numerous beneficial effects on health. Extensive research has been conducted over the years investigating and proving the hypoglycemic potential of various plants. The present paper reviews 37 such plants that are rich in phytoconstituents that possess a variety of pharmacological activities and have been experimentally proven to possess potentially hypoglycemic properties in animal models: Ficus racemosa, Agremone mexicana, Bombax ceiba, Cajanus cajan, Coccinia cordifolia, Momordica charantia, Syzygium cumini, Neolamarckia cadamba, Mangifera indica, Cocos nucifera, Tamarindus indica, Punica granatum, Azadirachta indica, Costus speciosus, Moringa oleifera, Andrographis paniculata, Ficus benghalensis, Anacardium occidentale, Annona squamosa, Boerhaavia diffusa, Catharanthus roseus, Cocculus hirsutus, Ficus hispida, Terminalia chebula, Terminalia catappa, Amaranthus tricolor, Blumea lacera, Piper betle leaves, Achyranthes aspera, Kalanchoe pinnata, Nelumbo nucifera, Mikania cordata, Wedelia chinensis, Murraya koenigii, Aloe barbadensis, Bryophyllum pinnatum and Asparagus racemosus. These 37 plant extracts exhibit antidiabetic activities through different mechanisms, including α-amylase and α-glucosidase inhibition, increases in glucose uptake and the stimulation of insulin secretion.

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Section: Piper Betle Leavesmentioning

confidence: 97%

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Zanzabil,

Hossain,

Hasan

2023

Diabetology

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“…Kim et al, 2008; C.T. Osoniyi & Onajobi, 2003;Rajput et al, 2014;Song et al, 2011;Yogeswari et al, 2020). Table 4 and Table 5 represent the antithrombotic activity of different plant extracts in the experiment set up with their possible mechanism of action.…”

Section: In Vitro and In Vivo An Thrombo C Inves Ga On Of Different P...mentioning

confidence: 99%

Current antithrombotic therapies and prospects of natural compounds in the management of the thrombotic disorder

Mazumder¹,

Salam²,

Mitra³

et al. 2022

NRFHH

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Thrombosis-associated cardiovascular and cerebrovascular disorders are the leading causes of global mortality and morbidity; this rate is alarmingly rising. A diverse class of antithrombotic drugs like antiplatelet and anticoagulant agents are frequently used to manage thrombus-induced physiological consequences, including cardiovascular and cerebrovascular diseases. But these agents have reported producing a series of adverse effects on the body, including potential bleeding episodes, which makes it urgent to discover antithrombotic therapy with higher efficacy, novel mechanisms of action, and fewer side effects. Research is still going on to isolate antithrombotic agents from various natural sources, and researchers are making remarkable progress in this field. In different experimental models, medicinal plant extracts and plant-derived bioactive compounds have been documented to produce antithrombotic activity through mechanisms like conventional drugs, with minimal or no side effects. Plant extracts and their bioactive compounds (phenolics, polysaccharides, peptides, terpenes, flavonoids) have proven their efficacy as potential candidates for developing safe antithrombotic therapy in numerous <i>in vivo</i> and <i>in vitro</i> models. Our review aims to introduce the readers to the relationship between thrombus formation and cardiovascular diseases (CVDs), problems with traditional therapies, and the role of natural resources in managing thrombus-induced cardiovascular and cerebrovascular diseases with possible mechanisms.

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“…baku pembuatan kripik karena sirih mudah ditanam dan mudah perawatannya, juga murah (Das et al, 2016;Rahmawati & Kurniawati, 2016). Sirih memiliki banyak khasiat untuk kesehatan (Das et al, 2016;Lubis et al, 2020;Misrita et al, 2020;Sumarya et al, 2016;Widowati et al, 2020), seperti ekstrak daun sirih, memiliki senyawa yang berperan dalam kebersihan mulut, mengandung unsur anti-diabetes dan anti kardiovaskular (Sarma et al, 2018;Toprani & Patel, 2013;Yogeswari et al, 2020).…”

Section: Mojito Sirihunclassified

Potensi Tanaman Sirih (Betel) sebagai Bahan Baku Pemberdayaan Ekonomi Produktif Masyarakat

Retnowati

Purwatiningtyas

Anwar

et al. 2022

AKS

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Sirih merupakan tanaman yang digunakan sebagai tanaman obat bagi masyarakat di Indonesia. Sirih tumbuh merambat sehingga tidak selalu memerlukan lahan yang luas. Tanaman ini dapat hidup subur di daerah yang dingin. Sidorejo Lor adalah kelurahan di kota Salatiga, yang berudara sejuk, di mana tanaman sirih banyak ditanam oleh masyarakat. Selain memiliki manfaat sebagai obat, sirih juga dapat menjadi bahan dasar produk olahan makanan dan minuman, yang bernilai ekonomi produktif. Masyarakat yang ingin diberdayakan dalam pengabdian pada masyarakat ini adalah kelompok Wanita kreatif (KWK) Seroja, dengan anggota ibu rumah tangga dan memiliki usaha rumahan. Dalam situasi pandemik Covid-19, anggota KWK Seroja berharap tetap berkreasi dengan menghasilkan produk ekonomi tetapi dengan bahan dasar yang mudah dan murah. Kegiatan ini bertujuan untuk memberikan contoh aplikatif, bernilai jual, melalui bahan dasar daun sirih, yaitu makanan ringan kripik sirih dan minuman mojito sirih. Selain itu kegiatan ini juga memberikan pemahaman tentang pentingnya produk kemasan sebagai media promosi. Hasilnya menunjukkan bahwa pertama, olahan kripik sirih dan mojito sirih dapat dibuat dengan mudah dan bernilai jual, kedua anggota KWK Seroja paham pentingnya kemasan produk sebagai sasaran pemasaran yang lebih luas.

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Antidiabetic, Antithrombin and Cytotoxic bioactive compounds in five cultivars of Piper betle L.

Cited by 14 publications

References 33 publications

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Current antithrombotic therapies and prospects of natural compounds in the management of the thrombotic disorder

Potensi Tanaman Sirih (Betel) sebagai Bahan Baku Pemberdayaan Ekonomi Produktif Masyarakat

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