Antidiabetic, cytotoxic and antioxidant activities of <i>Rhodomyrtus tomentosa</i> leaf extracts

Idris, Muddatstsir; Sukandar, Edwin Risky; Purnomo, Adi Setyo; Martak, Fahimah; Fatmawati, Sri

doi:10.1039/d2ra03944c

Cited by 19 publications

(6 citation statements)

References 35 publications

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“…In chronic lung disease patients, toxins and free radicals cause oxidative stress and lung tissue destruction. A quantitative UV-Vis spectrophotometer study found that the methanol fraction of Rhodomyrtus toementosa leaf methanol extract had the strongest antioxidant activity with an IC50 value of 51.95 g/mL ( Idris et al, 2022 ). Inflammation-induced oxidative stress may be caused by high IL-8 and insufficient glutathione.…”

Section: Discussionmentioning

confidence: 99%

Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) protects against allethrin-exposed pulmo damage in rats: mechanistic interleukins

Situmorang,

Ilyas,

Syahputra

et al. 2024

Front. Pharmacol.

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Inhaling Allethrin (C19H26O3) may induce oxidative stress in lung cells by causing the formation of free radi-cals. Interleukins (IL) are a group of secreted cytokines or proteins and signaling molecules initially produced as an immune response by leukocytes. Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) contains antioxidants that may prevent lung damage induced by allethrin-containing electric mosquito repellents. In this study, six groups of rats were exposed to allethrin via an electric mosquito repellent, including positive, negative, and comparison control groups and three groups were administered Rhodomyrtus tomentosa (Aiton) Hassk at 100 mg/kg BW, 200 mg/kg BW, and 300 mg/kg BW. After 30 days, the pulmonary tissue and the blood were taken for immunohisto-chemical and ELISA analysis. The accumulation of inflammatory cells causes the thickening of the alveolar wall structures. Injuries were more prevalent in the A+ group than in the other groups. The connection between the alveoli and blood capillaries, which can interfere with alveolar gas exchange, is not regulated, and the lu-minal morphology is aberrant, causing damage to the alveolar epithelial cells. Exposure to electric mosquito coils containing allethrin can increase the expression of interleukin-1, interleukin-8, interleukin-9, and interleu-kin-18 in blood serum and tissues while decreasing the expression of interleukin-6 and interleukin-10. Like the Vitamin C group, Rhodomyrtus tomentosa can increase alveolar histological alterations by decreasing the ex-pression of IL-1β, IL-8, IL-9, and IL-18 while increasing IL-6 and IL-10. So that this plant can be developed in the future as a drug to prevent lung harm from exposure.

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Section: Discussionmentioning

confidence: 99%

Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) protects against allethrin-exposed pulmo damage in rats: mechanistic interleukins

Situmorang,

Ilyas,

Syahputra

et al. 2024

Front. Pharmacol.

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“…Total phenolic content was determined based on the regular method applied in our laboratory 27 , 28 . The Modified Folin-Ciocalteu method was employed by mixing the sample (1000 ppm) with 10% Folin-Ciocalteu solution and 5% sodium carbonate.…”

Section: Methodsmentioning

confidence: 99%

The chemical profiles and cytotoxicity of gaharu bouya oil from Borneo’s Gonystylus bancanus wood

Oktavianawati,

Santoso,

Fatmawati

2024

Sci Rep

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Gaharu bouya oil obtained from distillation of the woods from Gonystylus genus has attracted essential oil industry interest. However, the information about gaharu bouya essential oil profile is limited. The presence of Gonystylus species is also critically endangered on the IUCN Red List. Therefore, exploring the -omics profiles of Gonystylus bancanus, a native plant from Borneo Island, is important for Indonesia to conserve the population. This research investigated the metabolite profiling of G. bancanus oil, especially the volatile components of its essential oils. Distillations were performed in two technical ways: hydrodistillation on a laboratory scale and steam distillation on an industrial scale. According to LC–MS and GC–MS profiles, both essential oils displayed similar chemical compositions. This article also discusses the similarity of the chemical contents of gaharu bouya oil and agarwood oil from the gaharu superior type (Aquilaria) to support the value of the oil. This research also investigated the cytotoxicity of gaharu bouya oil against three cell lines: HeLa, MCF-7, and HT-29.

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“…Nasution et al (2015) [41] discovered that betasitosterol compounds derived from the bark of the A. camansi plant may decrease blood sugar levels in male Swiss Webster rats. Idris et al (2022) [42] discovered that methanol extract from the leaves of the Rhodomyrtus tomentosa plant has antidiabetic effects of 82.41 ± 2.21% against α-amylase inhibition and 81.91 ± 1.09% against αglucoamylase inhibition. Methanol extracts from the Allium consanguineum plant inhibited α-amylase at concentrations of 62.5, 125, 250, 500, and 1000 μg/mL, which was 29.88 ± 0.89%, 42.78 ± 0.45%, 47.44 ± 0.86%, 64.72 ± 0.89%, and 75.29 ± 0.64% [43].…”

Section: -5-antidiabetic Testmentioning

confidence: 99%

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

Suhartati,

Prihatin,

Kurniati

et al. 2024

Emerg Sci J

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In this present work, a cycloartobiloxanthone compound was isolated from the stem wood and root bark of the Pudau plant (Artocarpus kemando Miq.). The purity of the compound was determined using thin-layer chromatography with three eluent systems and melting point tests. The sample was then analyzed using UV-Vis, IR, and NMR spectroscopy, ensuring that the compound is cycloartobilox-anthone. The cycloartobiloxanthone compound was obtained in a yellow crystalline form with a melting point of 285.1-294°C. The compound was then investigated for antidiabetic, anticancer, and antibacterial properties, showing that the compound has an anti-diabetic effect by reducing the activity of the α-amylase enzyme, with the highest percentage of inhibition of 48.53 ± 1.84% achieved with the use of 1000 ppm of the compound. Cycloartobiloxanthone isolated has an IC50 value of 9.21 µg/mL for anticancer activity against MCF-7 cells, indicating that the compound shows active cytotoxic actions. Staphylococcus aureus was very strongly inhibited by the compound in the antibacterial test at all doses, whereas for Salmonellasp., the activity was categorized as moderate at concentrations of 0.4 and 0.3 mg/disc and strong at 0.5 mg/disc. The anti-diabetic, anti-cancer, and antibacterial bioactivity studies indicated that the cycloartobiloxanthone compound isolated has a broad spectrum of pharmacological actions, indicating that the compound has promising potential. Doi: 10.28991/ESJ-2024-08-01-04 Full Text: PDF

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Antidiabetic, cytotoxic and antioxidant activities of Rhodomyrtus tomentosa leaf extracts

Abstract: As part of our project on exploring Indonesian medicinal plants for antidiabetic and anticancer agents, this study was conducted to investigate the total phenolic and flavonoid contents, and antioxidant, cytotoxic and antidiabetic properties of R. tomentosa leaf extracts.

Cited by 19 publications

References 35 publications

Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) protects against allethrin-exposed pulmo damage in rats: mechanistic interleukins

Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) protects against allethrin-exposed pulmo damage in rats: mechanistic interleukins

The chemical profiles and cytotoxicity of gaharu bouya oil from Borneo’s Gonystylus bancanus wood

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

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