Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits

Marmouzi, Ilias; Kharbach, Mourad; Jemli, Meryem El; Bouyahya, Abdelhakim; Cherrah, Yahia; Bouklouze, Abdelaziz; Heyden, Yvan Vander; Faouzi, My El Abbes

doi:10.1016/j.indcrop.2019.02.007

Cited by 56 publications

(41 citation statements)

References 40 publications

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“…[23] By chemical analysis, we can say that for all types of kidney stones, CaOx is the most common composition with a frequency of more than 80%. [24] Referenced studies [2,5] say that the leaves of Z. lotus contain several secondary metabolites such as flavonoids, polyphenols, saponins, tannins, and alkaloids; this result is in accordance with what has been obtained. The yield of the fraction rich in saponins is equal to 1.41% w/w; other study gives a yield of 0.34% this difference is due to the climatic conditions and to the extractions techniques.…”

Section: Discussionsupporting

confidence: 70%

“…[4] Several biologically active secondary metabolites are isolated from this plant, for example, the leaves notably made in phenolic acids, flavonoids, tannins, and saponins notably jujuboside B, jujubogenin glycosides, and jujubasaponine IV. [5] Other compounds are identified within the leaves such as monosaccharides (glucose, galactose, rhamnose, arabinose, and xylose), a flavonol organic compound, and 3', 5'-diglucosylphloretin. [2] The urinary stones are named supported the chemical composition, are composed of inorganic…”

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confidence: 99%

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Ahmed¹

2020

IJGP

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Introduction: A large number of medicinal plants have been used in Algeria since antiquity, which claims the efficient cure of urinary stone, one of these plants is the specie Zizyphus lotus (Family: Rhamnaceae). Leaves of this species are traditionally used for the treatment of many diseases. Nowadays, numerous clinical studies have provided reliable results on the effects of several hundred plants on several diseases such as the problem of urinary stones. The objective of this study is evaluated in vitro the activity antilithiasic of the extract saponins created fraction. Materials and Methods: Inhibition and dissolution of calcium oxalate (CaOx) were studied by the use of the techniques turbidimetric and gravimetric, using a ultraviolet-visible spectrophotometer and a precision balance. Results and Discussion: Qualitative secondary metabolites determination in the leaves of Z. lotus showed the presence of polyphenols, saponins, flavonoids, alkaloids, and tannins, and the yield of the fraction rich in saponins is equal to 1.41%. The absorbance decreased with the increase in the concentration of extract indicating that decreased the nucleation of CaOx particles with inhibition at 55.23 ± 1.23%. The weight of CaOx crystal decreased with the increase in the concentration of saponins, and the extract at 100% concentration possesses a maximum percentage of dissolution equal to 91.95 ± 0.72%. This effect could be attributed to Ca 2+ chelation by the compounds that exist in this fraction. Conclusion: This study indicates that extract can be considered as feasible natural products to improve the efficiency of CaOx inhibition and dissolution.

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Section: Discussionsupporting

confidence: 70%

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confidence: 99%

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Ahmed¹

2020

IJGP

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“…The test of α‐amylase inhibition was carried by the investigation of the effect of AIEO at different concentrations on enzymatic activity towards starch solution 27 . Briefly, 250 μL (0.02 mol/L in PBS) of α‐amylase (240 U/mL) were mixed with 250 μL of samples and incubated for 20 minutes at 37°C.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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Ajuga iva (A iva) is a medicinal plant used mainly in traditional medicine. This study was aimed to identify the volatile compounds of A iva essential oils (AIEO) at three developmental periods, and to evaluate their pharmacological properties. Chemical volatile compounds were identified by GC/MS analysis. Twenty‐eight volatile components were identified, belonging mainly to oxygenated monoterpenes and hydrocarbons monoterpenes. Carvacrol, octadecane, methyl chavicol were the major volatile components of AIEO at the three phenological stages. FRAP, DPPH and ABTS assays were adopted to estimate the antioxidant effects. AIEO at the vegetative stage exhibited important antioxidant effects with IC50 = 52.43 μg/mL (DPPH), IC50 = 115.22 μg/mL (FRAP), and, IC50 = 143.40 μg/mL (ABTS). The antidiabetic activity was evaluated in vitro by the inhibition of α‐amylase and α‐glucosidase. AIEO at the vegetative stage was the most active as an enzyme inhibitor of α‐amylase (IC50 = 101.727 μg/mL) and α‐glucosidase (IC50 = 86.93 μg/mL). The dermatoprotective effect was investigated by the in vitro inhibition of tyrosinase and elastase activities. AIEO at the vegetative stage showed the lowest IC50 inhibition values against tyrosinase (IC50 = 87.49 μg/mL) and elastase (IC50 = 192.21 μg/mL). Antifungal properties of AIEO were investigated on Trichophyton violaceum, T tonsurans and T mentagrophytes. The three EOs of A iva exhibited important inhibitions of the tested dermatophytes. The findings of this work showed that phenological stages affect significantly the volatile compounds of A iva, and these fluctuations influence mainly the biological properties. Moreover, further investigations concerning in vivo pharmacodynamic and pharmacokinetic investigations as well as clinical trials of these identified compounds could develop antidiabetic, dermatoprotective and anti‐dermatophyte drugs.

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“…Among these substances, polyphenols from jujube, secondary metabolites of plants, are important determinants of the nutritional and organoleptic qualities of Zizyphus lotus [21,22]. Several bioactive compounds extracted from jujubes have attracted the attention of many researchers due to their important biological actions, including antioxidant [19,23], enzyme inhibitory [24,25], antiproliferative and cytotoxic effects [24,26], anti-inflammatory, and other effects [27][28][29], which can be used in the food, pharmaceutical, and cosmetic industry.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant against DPPH (EC50 = 0.39 µg/mL) and FRAP (1670.42 ± 6.5 mg/100 g). Additionally, it possesses acetylcholinesterase (AChE) inhibitory effect (IC50 = 0.93 ± 0.01 mg/mL) and HMGR inhibition (45.41%) using 100 µg/mL. The extract significantly inhibits cell proliferation on the MCF-7 and HepG2 tumor cell lines with an IC50 values of <0.05 and 3 ± 0.55 mg/mL, respectively. Therefore, the ultrasound method can be considered a method for obtaining a significant anticancer activity with respect to the lines and therefore makes it possible to recover a maximum of phenolic compounds in less time with an AChE and HMGR inhibitory activity. Thus, it can be suggested that Zls extract is a promising fruit for the development of supplementary dietary due to its potential behaviour as nutraceutical.

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Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits

Cited by 56 publications

References 40 publications

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Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

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