Antidiabetic effect and antioxidant potential of Rosa canina fruits

Orhan, Nilüfer; Aslan, Mustafa; Hoşbaş, Sanem; Orhan, D Deliorman

doi:10.1055/s-0029-1234731

Cited by 23 publications

(26 citation statements)

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“…It is found that oxidative stress, causing by reactive oxygen species (ROS) of superoxide anion radicals, hydroxyl radicals, peroxyl radicals, and single oxygen, is a major factor in the pathogenesis of diabetes (Arrick et al, 2011;El Zahraa et al, 2012;Orhan et al, 2009). In diabetes, free radicals are formed through glucose oxidation, glycation of proteins, and a series of oxidative degradations of glycated proteins.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

Wan

Yang

Cai

et al. 2015

J. Ocean Univ. China

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In the present study, ultrasonic extraction technique (UET) is used to improve the yield of polysaccharides from Laminaria japonica (LJPs). And their antioxidative as well as glycosidase inhibitory activities are investigated. Box-Behnken design (BBD) combined with response surface methodology (RSM) is applied to optimize ultrasonic extraction for polysaccharides. The optimized conditions are obtained as extraction time at 54 min, ultrasonic power at 1050 W, extraction temperature at 80℃ and ratio of material to solvent at 1:50 (g mL −1 ). Under these optimal ultrasonic extraction conditions, an actual experimental yield (5.75% ± 0.3%) is close to the predicted result (5.67%) with no significant difference (P > 0.05). Vitro antioxidative and glycosidase inhibitory activities tests indicate that the crude polysaccharides (LJP) and two major ethanol precipitated fractions (LJP1 and LJP2) are in a concentration-dependent manner. LJP2 (30%60% ethanol precipitated polysaccharides) possesses the strongest α-glucosidase inhibitory activity and moderate scavenging activity against hydroxyl radicals (66.09% ± 2.19%, 3.0 mg mL −1 ). Also, the inhibitory activity against α-glucosidase (59.08% ± 3.79%, 5.0 mg mL −1 ) is close to that of acarbose (63.99% ± 3.27%, 5.0 mg mL −1 ). LJP1 (30% ethanol precipitated polysaccharides) exhibits the strongest scavenging activity against hydroxyl radicals (99.80% ± 0.00%, 3.0 mg mL −1 ) and moderate α-glucosidase inhibitory activity (47.76% ± 1.92%, 5.0 mg mL −1 ). LJP shows the most remarkable DPPH scavenging activity (66.20% ± 0.11%, 5.0 mg mL −1 ) but weakest α-glucosidase inhibitory activity (37.77% ± 1.30%, 5.0 mg mL −1 ). However, all these LJPs exert weak inhibitory effects against α-amylase. These results show that UET is an effective method for extracting bioactive polysaccharides from seaweed materials. LJP1 and LJP2 can be developed as a potential ingredient in hypoglycemic agents or functional food for the management of diabetes. This study provides scientific evidence and advances in the preparation technology and a hypoglycemic activities evaluation method for seaweed polysaccharides, especially glycosidase inhibition in combination with an antioxidative activity evaluation method.

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Section: Introductionmentioning

confidence: 99%

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

Wan

Yang

Cai

et al. 2015

J. Ocean Univ. China

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“…Morus nigra is eaten directly or as marmalade made from fruit and used for infection and aphthae by local people. It is also used for anemia (Özcan, 2003;Orhan et al, 2009); the ripe fruit is rub on the lips of children to treat herpes (Camejo-Rodrigues et al, 2003); used for eczema, hepatitis (Hayta et al, 2014), diabetes disease, oral wounds (Koca and Yıldırımlı, 2010) and cholesterol (Polat and Satıl, 2012). The leaves and shoots of Cistus laurifolius are boiled in water to drink and used for digestive problems.…”

Section: Discussionmentioning

confidence: 99%

On the Bayat (Turkey) rugs, motif stories, used dyeing plants and their ethnobotanical properties

2017

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Bayat rugs weaved with different madders can be used without fading their colors almost 100 years. The study aimed to record how to get madder by traditional methods from local plants, give stories of rug motives and present an overview of the medicinal uses of dyes plants collected in Afyonkarahisar, Inner-West Anatolia, Turkey. The study was conducted in both 11 villages and downtown of Bayat borough of Afyonkarahisar in 2013-2014. A total 150 women, aged between 17-25, were interviewed and observations were photographed. The rugs are completely 100% sheep wool and strings for weaving prepared traditionally by special spinning methods. The used plants to obtain the madders were determined. It was understood that in early August and September, plants give better colors and tones. These plants have also been used for medicinal purposes by the locals. Bayat people get non-fading colors from 11 plants (Allium cepa L., Berberis crataegina L., Papaver rhoeas, Papaver somniferum L., Malva silvestris L., Morus nigra L., Cistus laurifolius L., Quercus ithaburensis Decne. subsp. macrolepis (Kotschy) Hedge et Yalt, Rubia tinctorum L., Juglans regia L., Indigofera tinctoria L.) belonged to ten families. The plant organs used are root, shell, cupula, leaf, young shoot, and aerial parts of the plants. A natural mud is also used as alum in this region that provides to create dark colors, and prevents mixing the colors. It also inhibits fading the colors in the rugs' texture. It was also recorded that different motives in Bayat Rugs have also interesting historical stories.

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“…1 Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion and/or insulin action, which results in hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism. 2 It is a disease mainly resulting from idiosyncrasy of carbohydrate metabolism. It is mainly described by absolute (type І) or relative (type ІІ) lack in insulin emission or receptor desensitization to insulin, ensuing in hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

Dewangan¹,

Tiwari²,

Sharma³

et al. 2017

IJPER

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Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day's newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.

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Antidiabetic effect and antioxidant potential of Rosa canina fruits

Cited by 23 publications

References 0 publications

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

On the Bayat (Turkey) rugs, motif stories, used dyeing plants and their ethnobotanical properties

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

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