Antidiabetic effect of combination of fractionated-extracts of Andrographis paniculata and Centella asiatica: In vitro study

Fitrawan, Lom.; Ariastuti, Reni; Tjandrawinata, RR; Nugroho, A. E.; Pramono, Suwijiyo

doi:10.4103/2221-1691.245957

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…Meanwhile, in the Centella asiatica plant, glucose absorption is inhibited by destroying disaccharides and alpha-amylase. 15…”

Section: Combination Of Andrographis Paniculata and Centella Asiaticamentioning

confidence: 99%

Effect of Combination Herbal Plants Extracts on Diabetes Mellitus

Semesta,

Putri,

Hadisaputri

2023

ijbp

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Diabetes is a non-communicable disease with metabolic dysfunction characterized by high glucose levels due to damage to pancreatic β cells so that insulin cannot be secreted normally by the body. Diabetes mellitus cannot be cured, but it can only be controlled with appropriate treatment. Most of the available synthetic antidiabetic treatments have serious side effects and are quite expensive. Therefore, traditional herbal medicine is an alternative which is used for some people in maintaining normal blood sugar levels. The use of herbal therapy with a combination of plant extracts has the potential to be more effective in lowering blood sugar when compared to single plant extracts. The aim of this article review is that to compile and provide a scientific overview of the various studies which have been conducted previously regarding the effectiveness of combinations of herbal plant extracts in diabetes mellitus. A comprehensive literature study was conducted by using various electronic search databases with the keyword “Combination of antidiabetic extracts” and 30 international research journals which were combined into review articles were obtained which shows that combinations of plant extracts proved to be more effective in lowering blood glucose levels compared to single herbal plant extracts.

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“…Meanwhile, in the Centella asiatica plant, glucose absorption is inhibited by destroying disaccharides and alpha-amylase. 15…”

Section: Combination Of Andrographis Paniculata and Centella Asiaticamentioning

confidence: 99%

Effect of Combination Herbal Plants Extracts on Diabetes Mellitus

Semesta,

Putri,

Hadisaputri

2023

ijbp

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“…Ethanol extract of C. asiatica has given highly propitious hypoglycemic activity as its extract inhibited absorption of glucose by inhibition of both intestinal disaccharidase enzyme and α‐amylase 1 (Berawi et al, 2017 ; Kabir et al., 2014 ). Fitrawan et al performed in vitro experiment on C. asiatica fraction with the combination of Andrographis paniculata herb fraction and found that 10 and 30 μg/ml concentrations, respectively, were able to increase insulin‐stimulated glucose uptake (Fitrawan et al, 2018 ). Assessment of the antidiabetic activity of ethyl acetate (EtOAc) extract fraction and isolated compounds were conducted against yeast α‐glucosidase.…”

Section: Selected Functional Food and Its Bioactivitiesmentioning

confidence: 99%

Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications

et al. 2021

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COVID‐19 has become the focal point since 2019 after the outbreak of coronavirus disease. Many drugs are being tested and used to treat coronavirus infections; different kinds of vaccines are also introduced as preventive measure. Alternative therapeutics are as well incorporated into the health guidelines of some countries. This research aimed to look into the underlying mechanisms of functional foods and how they may improve the long‐term post COVID‐19 cardiovascular, diabetic, and respiratory complications through their bioactive compounds. The potentiality of nine functional foods for post COVID‐19 complications was investigated through computational approaches. A total of 266 bioactive compounds of these foods were searched via extensive literature reviewing. Three highly associated targets namely troponin I interacting kinase (TNNI3K), dipeptidyl peptidase 4 (DPP‐4), and transforming growth factor beta 1 (TGF‐β1) were selected for cardiovascular, diabetes, and respiratory disorders, respectively, after COVID‐19 infections. Best docked compounds were further analyzed by network pharmacological tools to explore their interactions with complication‐related genes (MAPK1 and HSP90AA1 for cardiovascular, PPARG and TNF‐alpha for diabetes, and AKT‐1 for respiratory disorders). Seventy‐one suggested compounds out of one‐hundred and thirty‐nine (139) docked compounds in network pharmacology recommended 169 Gene Ontology (GO) items and 99 Kyoto Encyclopedia of Genes and Genomes signaling pathways preferably AKT signaling pathway, MAPK signaling pathway, ACE2 receptor signaling pathway, insulin signaling pathway, and PPAR signaling pathway. Among the chosen functional foods, black cumin, fenugreek, garlic, ginger, turmeric, bitter melon, and Indian pennywort were found to modulate the actions. Results demonstrate that aforesaid functional foods have attenuating roles to manage post COVID‐19 complications. Practical applications Functional foods have been approaching a greater interest due to their medicinal uses other than gastronomic pleasure. Nine functional food resources have been used in this research for their traditional and ethnopharmacological uses, but their directive‐role in modulating the genes involved in the management of post COVID‐19 complications is inadequately studied and reported. Therefore, the foods types used in this research may be prioritized to be used as functional foods for ameliorating the major post COVID‐19 complications through appropriate science.

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