Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats

Reddy, Murali Mohan Rama Krishna; Saravanan, R.

doi:10.1016/j.bionut.2012.08.008

Cited by 140 publications

(80 citation statements)

References 49 publications

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“…A number of monoterpenes are widely used in the agriculture, cosmetic and food production (Aeschbach et al 1994;Lee et al 1997;Manou et al 1998). They contain diverse pharmacological properties with antidiabetic, hypocholesterolaemic, hypotensive, vasorelaxant, antioxidant, anticancer, antifungal, antibacterial and anti-spasmodic (Marcio et al 2011;Murali & Saravanan 2012;Ezhumalai et al 2014). Previous reports documented that monoterpenes could be functional phytochemicals for the management of cardiovascular diseases (CVD) (Bastos et al 2010;Peixoto-Neves et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

Ayyasamy

Pari

2016

Pharmaceutical Biology

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Context: Myrtenal is monoterpene a constituent of essential oils found mainly in herbs such as mint, pepper, cumin, etc. It exerts admirable pharmacological activities against many diseases including diabetes. Hyperlipidaemia is a secondary complication of diabetes and also a major risk factor for cardiovascular diseases.Objective: The present study investigated the possible antihyperlipidaemic efficacy of myrtenal on plasma glucose, pancreatic insulin, plasma and tissue lipid levels in streptozotocin (STZ) induced diabetic rats. Materials and methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Myrtenal (80 mg/kg) was administered orally to diabetic rats for a period of 28 d. Plasma glucose, pancreatic insulin, TC, TGs, FFAs, PLs, LDL-C, HDL-C, VLDL, atherogenic index, (HMG-CoA) reductase, LPL, LCAT and liver histology were analyzed. Results: Diabetic rats showed significantly (p < 0.05) increased plasma glucose (273.18 mg/dL), total cholesterol (142 mg/dL), triglycerides (126 mg/dL), free fatty acids (118 mg/dL), phospholipids (153 mg/dL), lowdensity lipoprotein (88.07 mg/dL), very low-density lipoprotein (25.2 mg/dL), atherogenic index, whereas a decrease in the levels of pancreatic insulin (97.48 ng/mg) and high-density lipoprotein (29.12 mg/dL). In addition, the activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase (0.94 HMG-CoA ratio/(mevalonate) increased significantly in contrast to the activities of lipoprotein lipase (4.87 lmoles of glycerol liberated/h/L) and lecithin cholesterol acyltransferase (54.61 lmoles of cholesterol esterified/h/L) in diabetic rats. Treatment with myrtenal significantly (p < 0.05) improved the levels of plasma glucose, pancreatic insulin and lipid profiles. Moreover, the histopathological analysis of liver was also in agreement with the biochemical findings. Discussion and conclusions: The present study indicates that myrtenal possess antihyperglycaemic and antihyperlipidemic properties, and could potentially be a useful phytochemical in treating diabetes. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

Ayyasamy

Pari

2016

Pharmaceutical Biology

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“…Yapılan bir çalışmada çam yağında terpen bileşiklerinin yoğun bir şekilde bulunduğu [12] ve bileşiklerin önemli antioksidan özellikleri olduğu belirlenmiştir [27,28]. Bir terpen olan D-limonenin antioksidan aktiviteye sahip olduğu, deneysel diyabette antidiyabetik özellikler gösterdiği [29,30] ayrıca dislipidemi ve hiperglisemi gibi metabolik bozuklukların önlenmesi ve iyileştirilmesinde yararlı etkileri olabileceği ifade edilmiştir [31].…”

Section: Discussionunclassified

“…STZ, langerhans adacıklarında bulunan ve insülin üreten β-hücrelerini tahrip ederek bu hücrelerin salgıladığı insülin miktarında azalmaya yol açarak hiperglisemik bir durumun ortaya çıkmasına sebep olmaktadır. Sonuçta kanda insülin düzeyi azalır, glukoz düzeyi artar [30]. İnsülin düzeyinde ortaya çıkan azalma kolesterol biyosentezine katılan enzimler ile transkripsiyon faktörünün aktivitesini engellemesi neticesinde kas dokusunda kolesterol düzeyi artmış olabilir.…”

Section: Discussionunclassified

Tip-1 Diyabet Oluşturulan Sıçanların Kas Dokusunda Bazı Biyokimyasal Değişikliklere Karşı Çam Yağının Etkisi

Demir

Yılmaz

2015

Mar. J. Pure Appl. Sci.

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ÖZETBu çalışma, Tip-1 diyabet oluşturulan sıçanlarda çam yağının kas dokusundaki bazı biyokimyasal parametreler üzerine etkisinin araştırılması için tasarlandı. Sıçanlar kontrol (K), streptozotosin (STZ) ve streptozotosin+çam yağı (STZ+ÇY) olmak üzere üç grubu ayrıldı. STZ gruplarına intraperitoneal enjeksiyonla streptozotosin (65mg/kg) verilerek diyabet oluşturuldu. Çam yağı grubundaki sıçanlara haftada iki gün 1mL/kg dozunda intraperitoneal enjeksiyonla çam yağı, ayrıca deney boyunca çam yağı (0,5mL/500mL) içme suyuna eklenerek verildi. Kontrol grubuna göre, STZ grubunda MDA düzeyinin anlamlı bir şekilde arttığı (p < 0,001), GSH ve total protein düzeyinin (p < 0,001) anlamlı bir şekilde azaldığı belirlendi, STZ grubu ile karşılaştırıldığında, uygulanan çam yağı sonucunda MDA düzeyinin anlamlı bir şekilde azaldığı (p < 0,001), GSH ve total protein düzeyinin anlamlı bir şekilde arttığı (p < 0,001) tespit edildi. Kontrol grubuna göre, STZ grubunda yağ asidi kompozisyonu, A, D, E ve K vitaminleri, kolesterol ve sterol düzeyinde önemli değişikliklerin olduğu, uygulanan çam yağının bu değişiklikleri önemli ölçüde engelleyebildiği saptandı. Elde ettiğimiz bulgulara göre, çam yağının kas dokusunda deneysel diyabetin neden olduğu bazı biyokimyasal metabolik düzensizliklerin azaltılmasında yararlı etkileri olduğu ortaya çıkmıştır.Anahtar kelimeler: Deneysel diyabet, oksidatif stres, yağ asidi kompozisyonu, A, D, E ve K vitaminleri, kolesterol ve sterol Effects of Pine Oil Aganist Some Biochemical Parametres Occurring Muscle Tissue of The Ratsİnduced Type-1 Diabetes ABSTRACTThe present study was designed to evaluate the impact of pine oil on some biochemical parameters in muscle tissue of streptozotocin-induced type-1diabetic rats. The rats were divided into three groups: control (C) streptozotocin (STZ), streptozotocin+pine oil (STZ+PO) grups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (65 mg/kg). 1 mL/kg the dose pine oil was intraperitoneally injected twice in a week to the streptozotocin+pine oil (STZ+PO), and additionally 0.5 mL /500 mL dose of pine oil was added to drinking water of these group. MDA levels of muscle tissue was increased significantly (p < 0,001) in STZ group and glutathione (GSH) level muscle tissue was decreased significantly (p < 0,001) when compared to control group. It was detected that MDA levels of muscle tissue significantly was decreased (p < 0,001) and GSH level was significantly (p < 0,001) inreased in the STZ+PO group compared to STZ group. The fatty acid composition, A, D, E and K vitamins, cholesterol and sterol levels significantly were changed in the control group compared to STZ group, in addition to, the applied pine oil can significantly inhibited these changes in muscle tissue. According to our findings, it was observed that the pine oil has beneficial effects in the decreasing of some biochemical metabolic disorders caused by experimental diabetes in the muscle tissue.

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“…It was found that the antidiabetic effect of d-limonene was comparable with glibenclamide and the effect of d-limonene was more pronounced in the doses of 100 mg/kg body weight than the other two doses 48 . More et al (2014) have demonstrated that 100 µM concentration of limonene demonstrated 85.61% inhibition of protein glycation while the positive control aminoguanidine demonstrated 88.02% inhibition at 1 mM concentration in STZ induced diabetic rats 49 .…”

Section: Antioxidant Phytochemicals In Diabetes Limonenementioning

confidence: 95%

Beneficial effects of commonly used phytochemicals in diabetes mellitus

Bacanlı¹,

Göktaş²,

Başaran³

et al. 2016

actapharm

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Diabetes mellitus, a metabolic disorder, is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycemia. The prevalence of diabetes is increasing worldwide, especially in developing countries. The diabetes treatment has higher costs, limited efficacy and side effects. As a result of these factors, patients often have used alternative forms of therapy such as herbal medicines. Plants often contain various amounts of phenolics, flavonoids and tannins and most of the studies are focused on the antidiabetic effects of these phytochemicals due to their antioxidant properties. In this review, the role of oxidative stress on diabetes and the effects of different phytochemicals (limonene, sinnamic acid and ursolic acid) to diabetes mellitus therapy will be discussed.

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Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats

Cited by 140 publications

References 49 publications

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

Tip-1 Diyabet Oluşturulan Sıçanların Kas Dokusunda Bazı Biyokimyasal Değişikliklere Karşı Çam Yağının Etkisi

Beneficial effects of commonly used phytochemicals in diabetes mellitus

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