Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats

Pari, Leelavinothan; Saravanan, R.

doi:10.1111/j.1462-8902.2004.0349.x

Cited by 83 publications

(45 citation statements)

References 30 publications

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“…4). Decreased fasting glucose could improve the body weight in diabetic rats, and this is consistent with other studies (Pari & Saravanan 2004, Nagarajan et al 2005. Another possible mechanism of the antidiabetic activity of G. alata, in addition to improving insulin secretion, is by delayed glucose absorption.…”

Section: Day 15supporting

confidence: 80%

The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function, and improvement of antioxidant activity in streptozotocin-induced diabetic rats

Hafizur¹,

Babiker²,

Yagi³

et al. 2012

Journal of Endocrinology

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In Sudanese folk medicine, Geigeria alata roots have been used for the management of diabetes for a long time. However, its antidiabetic activity is unreported. In this study, G. alata methanolic extract was tested for its antidiabetic, antioxidant, and b-cell modulatory effects in a streptozotocin-induced diabetic rat model. In this model of diabetic rats, the oral glucose tolerance test with G. alata extract at 125, 250, and 500 mg/kg doses revealed the efficacy of the 250 mg/kg dose in improving glucose tolerance comparable to the standard drug glibenclamide. Diabetic rats were treated with a 250 mg/kg dose of G. alata extract orally for 2 h (acute) or 14 days (chronic). In the case of acute treatment, the extract lowered blood glucose levels significantly at 120 min both in nondiabetic and diabetic rats. Chronic treatment of diabetic rats with 250 mg/kg of G. alata extract resulted in a significant decrease in blood glucose level closer to that of nondiabetic rats. Interestingly, increased serum insulin, improved b-cell function, and antioxidant status were observed in G. alata-treated diabetic rats. G. alata also showed strong antioxidant and a-glucosidase inhibitory activities in in vitro assays. These data show direct evidence that G. alata has antidiabetic activity and suggest that the antidiabetic activity is due to enhanced insulin secretion, modulation of b-cell function, and improvement of antioxidant status.

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Section: Day 15supporting

confidence: 80%

The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function, and improvement of antioxidant activity in streptozotocin-induced diabetic rats

Hafizur¹,

Babiker²,

Yagi³

et al. 2012

Journal of Endocrinology

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“…Several workers have shown that hyperglycemia and hyperlipidemia are the common characteristics of alloxan-induced diabetes mellitus in experimental animals (Pari and Saravanan, 2004;Qiong et al, 2004;Umesh et al, 2005).…”

Section: Discussionmentioning

confidence: 97%

Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats

Leite

Araújo

Carvalho

et al. 2007

Journal of Ethnopharmacology

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“…Many oral antihyperglycemic agents have significant side effects and some are ineffective in chronic diabetic patients [4]. In spite of the introduction of hypoglycemic drugs, diabetes and related complications continue to be a major medical problem [5].…”

Section: Introductionmentioning

confidence: 99%

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

2016

IJSR

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The present study was conducted to investigate the beneficial effects of taurine (TAU) on glucose and lipid metabolism and its positive roles in the correction of oxidative stress diabetes-related complications in STZ diabetic rats. Diabetic rats showed significant (P<0.05) increase in the levels of glucose, HbA1c, AST, ALT, LDH, liver and kidney weights, urea, uric acid, creatinine and significant decrease in the levels of body and pancreas weights, insulin, pancreatic amylase, hexokinase, liver and muscle glycogen, total protein, albumin, antioxidant enzymes and HDL-C. Also, higher levels of cholesterol, TG, total lipids, LDL-C and MDA were noticed in diabetic rats. The taurine administration (50 mg/kg) showed antihyperglycemic effect as indicated by reduced glucose levels, HbA1c and improved insulin level and carbohydrate hydrolyzing enzymes. In addition, taurine supplementation normalized liver function and inhibited lipid prfile alterations while, kidney weight, urea, creatinine, uric acid, total protein and albumin levels were partially improved. The obtained results revealed that taurine exhibited an inhibitory effect on oxidative stress indices (MDA) and partially improved antioxidantlevels. Taurine could have potential as a pharmaceutical drug for diabetes mellitus (DM). Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.

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Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats

Cited by 83 publications

References 30 publications

The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function, and improvement of antioxidant activity in streptozotocin-induced diabetic rats

The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function, and improvement of antioxidant activity in streptozotocin-induced diabetic rats

Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

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