Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats

Abstract

This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000917.

Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats

“…Hypertriglyceridaemia has been reported in diabetic animals [26,50]. This was observed to be due to elevated absorption and formation of triglycerides in the form of chylomicrons sequel to exogenous consumption of diet rich in fat or through elevated endogenous production of triglyceride-enriched hepatic VLDL-cholesterol and decreased triglyceride uptake in peripheral tissues [26,27].…”

“…This was associated to the elevated dietary cholesterol absorption from the small intestine sequel to the intake of high fat diet in a diabetic state [27].…”

“…However, the concentrations of serum triglyceride, VLDL-cholesterol and total cholesterol were significantly lowered in animals treated with varying doses of A. cepa juice when compared with those of the negative control group (diabetic but untreated animals) in the present study. Moreover, it can be conjectured that the lipid lowering effects of A. cepa bulb could be due to the inhibition of hepatic cholesterol, triglyceride and possibly fatty acid synthesis by the phenolic constituents of A. cepa bulb [27].…”

“…In the creasing HDL-cholesterol, and has generally been considered proatherogenic [21,52]. This probably explains why A. cepa bulb may lead to a reduction in the risk of developing heart diseases since a high HDL-cholesterol/LDL-cholesterol ratio has been shown to be beneficial and is indicative of a lower risk of cardiovascular diseases [27,53].…”

“…HDL and LDL are two of the four main groups of plasma lipoproteins that are involved in lipid metabolism and the exchange of cholesterol, cholesterol ester and triglycerides between tissues [54,55]. Several researches have reported an inverse relationship between plasma HDL-cholesterol levels and risk of cardiovascular disease, implying that factors attributed with HDL-cholesterol protects against atherosclerosis [27,33]. Some of these factors appear…”