Antidiabetic effect of Ficus bengalensis aerial roots in experimental animals

Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats

“…This translates to 146.3 mg/kg daily (for an 80 kg person) and compares with the dose found to be effective in this study. The observation that the efficacy of CM extract decreased with increased dose is consistent with findings of studies on some botanical agents (Kesari et al, 2005(Kesari et al, , 2006Singh et al, 2007Singh et al, , 2009Rai et al, 2008). A lower concentration than 100 mg/kg may have been optimal.…”

Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition

“…Other species from the ficus genus, namely, F. religiosa Linn, F. racemosa Linn, F. bengalensis Linn, F. carica Linn, and F. exasperata Vahl. also exhibited blood glucose lowering effect with no signs of toxicity at its effective or highest dose evaluated (Dominguez et al, 1996;Bafor and Igbinuwen, 2009;Singh et al, 2009;Pandit et al, 2010;Veerapur et al, 2012). Similarly, F.deltoidea methanol extract exhibited no sign of toxicity at a single oral gavage dose of 6400 mg/kg or administered daily over a period of four weeks at 200 mg/kg.…”

Protective effect of Ficus bengalensis L. extract against H2O2 induced DNA damage and repair in neuroblastoma cells

“…Maximal survival of cells was observed in the presence of aqueous extract (AFB). It has been supported by some authors that the constituents present in the extract may decrease the levels of lipid peroxidation products by scavenging free radicals like superoxide anion, hydroxyl and peroxy-free radicals 6,7,13 . Miranda et al 14 also reported that protection may be afforded by the antioxidant activity of the mate tea's bioactive compounds.…”

“…Pharmacological investigations of FB indicated the presence of interesting biological activities such as anti-diabetic 6,7 , and anti-bacterial agent 8 . However, information pertaining to the protective properties of FB on neurological disorders is lacking though it has been using traditionally.…”