Antidiabetic Effect of Oleuropein from Olea europaea Leaf against Alloxan Induced Type 1 Diabetic in Rats

Qadir, Nadir Mustafa; Ali, Kawa A.; Qader, Suhailah Wasman

doi:10.1590/1678-4324-2016150116

Cited by 21 publications

(12 citation statements)

References 25 publications

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“…On the other hand Table 9 showed that the Granulocytes (GRA) of normal nutrition of rats, was 38.0% while after supplementation with olive pomace attribution 2.5, 5, 7.5 and 10%, of nutrition of rats on (GRA) they were 38.5, 39.0 and 39.7%, respectively. This results agreed with Mahmoud et al (2013), Nandakumaran et al (2014) and Nadir et al (2016) who found the effects of oleuropein on hematological analysis including (RBCs, Hb, PCV and PLTs) in plasma of experimental rats, which were 7.44(x10 6 /μL), 14.2(g/dl), 44.25% and 434.00(x10 3 /μL), at treatment 10mg/kg, respectively compared to those of normal control rats, which were 6.75(x106/μL), 12.82(g/dl), 40.35% and 456.13(x103/μL), at treatment 10mg/ kg, respectively.…”

Section: Data Insupporting

confidence: 93%

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Elkotb

Elsanat

Saleh

2017

Journal of Sustainable Agricultural Sciences

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THIS WORK was conducted to study the effects of different levels of olive pomace (OP) on body weight gain, feed intake and feed conversion efficiency of rats. Experimental rats nutrition supplemented to diabetic rats (7 rats in each group) for 42 day. After the 42 nd day, chemical analysis of marker enzyme (MDA, TAC and SOD), liver function (ALT, AST and T-protein), kidney functions (Creatinine and Blood urea), lipid profile (triglycerides, total cholesterol, HDL, LDL and vLDL), and haematological analysis was recorded. The highest effects of supplementation of olive pomace in rats nutrition on body weight of rats, were 200, 200, 205 and 225 g, of treatments (2.5, 5, 7.5 and 10% of OP), respectively as compared with normal control (0 % OP), which was 190 g. Also, the most effective treatments were 10% of OP of blood biochemical and haematological parameters, comparing with normal nutrition. Therefore, it is recommended to add olive pomace at 5%, 7.5% and 10% in rats nutrition to improve performance and health.

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Section: Data Insupporting

confidence: 93%

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Elkotb

Elsanat

Saleh

2017

Journal of Sustainable Agricultural Sciences

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“…In addition, it seems that hyperglycemia is accompanied by an increase in free radicals in the body. Furthermore, food antioxidants are effective in reducing the complex effects resulting from oxidative stress of diabetes type I (20). Chronic hyperglycemia induces carbonyl stress, which in turn increases lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Effects of Oleuropein in Streptozotocin Induced Diabetic Male Rat

Amirnahavandirahbar

Nasirzadeh

2018

Macedonian Veterinary Review

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Diabetes is a chronic disease characterized by a disorder in the metabolism of proteins, fats, and carbohydrates. The liver as a non-insulin dependent organ plays an important role in the regulation of blood fat and glucose. Most blood glucose lowering drugs that are introduced for treatment have side effects in long-term consumption. Therefore, to control diabetes and its complications, the use of herbal drugs is widely considered nowadays. The present study investigates the biochemical effects of oleuropein in diabetic male rats. In this study, 30 adult male Wistar rats with a weight range of 190±30 gr were equally divided into 3 groups randomly: 1) control group or intact animals, 2) diabetic animals, and 3) treatment group, which received 60 mg/kg oleuropein for 30 days by gastric gavage. Diabetes was induced in diabetic and treatment groups by injection of streptozotocin (60 mg/kg) intraperitoneally. At the end of the treatment, the levels of triglyceride, cholesterol, LDL, HDL, VLDL, blood glucose, HbA1C, and activity of AST and ALT were determined. The results showed that the serum lipid profile and blood glucose increased significantly in the diabetic group compared with the control group (p<0.05). Also, HbA1C and atherogenic index decreased significantly in the treatment group compared with the diabetic group (p<0.05). This study showed that oral administration of oleuropein has hypoglycemic effects, which can reduce the serum levels of the lipids profile and the atherogenic index in streptozotocin-induced diabetic male rats.

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“…A negative correlation was noticed between GSH and hyperglycemia, which means that rising serum glucose reduced the antioxidant capacity (Qadir et al, 2016). There is an inverse correlation which has been revealed among glucose level and enzymatic and non-enzymatic antioxidants (Qadir et al, 2016).…”

Section: Changes In Mda and Gsh Of Normal And Diabetic Ratsmentioning

confidence: 93%

“…In fact, oleuropein represented more than 50% of the total recognized compounds in olive leaves,followed by hydroxytyrosol, then many other phenolics (Charoenprasert and Mitchell, 2012). Oleuropein inhibitted the activities of free radicals and inhibitted oxidative stress in diabetic-induced rats (Qadir et al, 2016). The potent antioxidant activity of olive leaf extract could be attributed to its high total polyphenolic compound content, and oleuropein (Salah et al, 2012).…”

Section: Dpph Free Radical Scavenging Activity Of Olive Leaf Extractmentioning

confidence: 99%

“…There is an inverse correlation which has been revealed among glucose level and enzymatic and non-enzymatic antioxidants (Qadir et al, 2016). The consumption oleuropein-rich olive leaf extract reduced plasma MDA levels in subjects, which was associated with higher plasma levels of metabolites derived from oleuropein (GarciaVillalba et al, 2014).…”

Section: Changes In Mda and Gsh Of Normal And Diabetic Ratsmentioning

confidence: 99%

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<em>In vivo</em> correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats

et al. 2018

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SUMMARY:Diabetes mellitus type two (T2DM) is one of the most extensive diseases in the world. Herbal therapy remains a possible adjunct therapy to sustain better glycemic control and reduce complications arising from diabetes. In order to evaluate the curative impacts of olive leaf extract (OLE) on streptozotocin (STZ)-induced diabetic rats, twenty-four Wistar male adult rats were divided into four equal groups; control, diabetic control (45 mg/kg STZ), normal rats treated with OLE (17.8 mg/kg b.wt.), and diabetic rats treated with OLE (45 mg/kg STZ + 17.8 mg/kg b.wt.). The OLE extract was investigated for in vitro antioxidant activity using the DPPH • assay. The phenolic, tannin, and flavonoid contents were determined. The activity of GPX, SOD, and GSH in RBC lysate, CAT in plasma and MDA in serum were measured. The OLE prevented the decrease in GSH and kept MDA around the normal range in the treated diabetic rats. The current study suggests that OLE might be used safely to ameliorate T2DM and its accompanying oxidative stress. KEYWORDS: Antioxidant enzymes activity; Diabetes mellitus type two; Flavonoids; Olive leaves extract; Oxidative stress; PhenolicsRESUMEN: Acción de extractos de hojas de olivo sobre marcadores del estrés oxidativo en diabetes mellitus inducida por estreptozotocina en ratas. La diabetes mellitus tipo dos (DM2) es una de las enfermedades más extensas en el mundo. La terapia con hierbas sigue siendo una terapia complementaria para mantener un mejor control de la glucemia y reducir las complicaciones de la diabetes. Con el fin de evaluar los efectos curativos del extracto de hojas de olivo (OLE) en ratas diabéticas inducidas por estreptozotocina (STZ), veinticuatro ratas Wistar machos adultos se dividieron en cuatro grupos iguales; control, control diabético (45 mg/ kg STZ), ratas normales tratadas con OLE (17.8 mg/kg b.wt) y ratas diabéticas tratadas con OLE (45 mg / kg STZ + 17.8 mg / kg b.wt.). El extracto OLE se investigó para determinar la actividad antioxidante in vitro usando ensayos DPPH • . Se determinaron los fenoles, los taninos y el contenido de flavonoides. Se midió la actividad de GPX, SOD y GSH en lisado de RBC, CAT en plasma y MDA en suero. El OLE evitó la disminución de GSH y mantuvo MDA alrededor del rango normal en las ratas diabéticas tratadas. El estudio actual sugiere que OLE podría utilizarse de forma segura para mejorar la DM2 y el estrés oxidativo que le acompaña. PALABRAS CLAVE: Actividad de enzimas antioxidantes; Diabetes mellitus tipo dos; Estrés oxidativo; Extracto de hojas de olivo; Fenólicos FlavonoidesORCID ID: Afify AMR https://orcid.org/0000-0001-8096-7649, El-Beltagi HS https://orcid.org/0000-0003-4433-2034, Fayed SA https://orcid.org/0000-0002-3449-6679, El-Ansary AE https://orcid.org/0000-0003-0585-1229Citation/Cómo citar este artículo: Afify AMR, El-Beltagi HS, Fayed SA, El-Ansary AE. 2108. In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats. Grasas Aceites 69 (1), e243. https:/...

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Antidiabetic Effect of Oleuropein from Olea europaea Leaf against Alloxan Induced Type 1 Diabetic in Rats

Abstract: ABSTRACT

Cited by 21 publications

References 25 publications

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Biochemical Effects of Oleuropein in Streptozotocin Induced Diabetic Male Rat

<em>In vivo</em> correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats

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