Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Bagri, Priyanka; Ali, Mohd.; Aeri, Vidhu; Bhowmik, Malay; Sultana, Shahnaz

doi:10.1016/j.fct.2008.09.058

Cited by 207 publications

(155 citation statements)

References 32 publications

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“…Diabetes mediated oxidative stress also correlates with depletion in the activity of non-enzymatic antioxidants such as GSH, and Vit-C (Ramar et al 2012). An elevated GSH ratio in EFSD (200, 400 and 800 mg/kg b.wt) treated groups showed that EFSD increases the GSH biosynthesis and prevents toxic effects against the increased ROS (Bagri et al 2009). The increased level of Vit-C in EFSD (200, 400 and 800 mg/kg b.wt) treated groups confirms the reduced utilisation of Vit-C against the augmented ROS (Srinivasan & Pari 2012).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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“…Diabetes was induced through a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (60 mg/kg) in overnight fasted rats (Bagri et al, 2009). After 72 hours, fasting blood glucose level were measured using glucometer (ACCU-CHEK® Performa, Roche Diagnostics).…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Zainalabidin¹,

Budin²,

Anuar³

et al. 2018

J App Pharm Sci

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Chronic hyperglycaemia produces excessive free radicals which could lead to diabetic complications. Hibiscus sabdariffa Linn. is proven to have high antioxidant and antihyperlipidemic properties. The aim of the study was to investigate the effects of H. sabdariffa polyphenol-rich extract (HPE) in the aorta of diabetic rats. Twenty-four male rats were randomly divided into three groups, i.e. non-diabetes mellitus (NDM), diabetes mellitus (DM) and diabetes mellitus with HPE (DM + HPE). HPE at 100 mg/kg or saline as control vehicle were administered daily through oral gavage for 28 days prior to sacrification and the aorta was isolated for further analysis. The glucose level in DM + HPE was significantly lower compared to DM, indicating its potential as an antidiabetic agent. Conversely, catalase (CAT), superoxide dismutase (SOD) activity and the level of glutathione (GSH) in DM + HPE were significantly higher than DM. The level of malondialdehyde (MDA) and protein carbonyl were significantly lower in DM + HPE than DM. Lipid profile analysis demonstrated a significant decrease in triglyceride, total cholesterol and LDL-C in DM + HPE compared to DM, however, HDL-C was significantly increased. Microscopic observation showed a disrupted morphology of the thoracic aorta in diabetic rats. HPE may exert protective effects by acting as an antidiabetic, antihyperlipidemic and antioxidant agent to the thoracic aorta in diabetic rats.

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“…The protective effect of pomegranate flowers' extracts (PFLE) was investigated by some authors on blood glucose level, serum lipid profile, total cholesterol, LDL, pancreatic lipid peroxidation and activities of both enzymatic and non-enzymatic antioxidant status in diabetic rats (Huang et al, 2005a,b;Lei et al, 2007;Lan et al, 2009;Bagri et al, 2009). The authors reported that the increase in blood glucose level, total cholesterol, triglycerides, LDL-cholesterol, very low density lipoproteins, lipid peroxidation level with decrease in high density lipoprotein (HDL)-cholesterol, glutathione content and antioxidant enzymes namely, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase and catalase can be reversed by administration of aqueous PFLE.…”

Section: Antidiabetic Properties (Glucose and Lipid Metabolism Activity)mentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Cited by 207 publications

References 32 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

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