Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

Bule, Mohammed Hussen; Abdurahman, Ahmed Abdulahi; Nikfar, Shekoufeh; Amini, Mohsen

doi:10.1016/j.fct.2019.01.037

Cited by 129 publications

(64 citation statements)

References 61 publications

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“…Procyanidins are related to a decrease in the risk of developing cardiovascular diseases . Isorhamnetins have anticancer activity and are known to promote the apoptosis of colon cancer cells, whereas quercetins are related to antidiabetic activity …”

Section: Resultsmentioning

confidence: 99%

“…41 Isorhamnetins have anticancer activity and are known to promote the apoptosis of colon cancer cells, 42,43 whereas quercetins are related to antidiabetic activity. 44 Regardless of the method adopted, grouping analyses based on flavonoids were successful in identifying genotypes adapted to dry environments. Flavonoids, known for a wide range of health benefits such as anticancer, anti-inflammatory, cardiovascular and cerebrovascular activities, [45][46][47] were found in high concentrations in BR1 and Senegal 55 437, genotypes that are highly tolerant to drought.…”

Section: Cluster Analyses Based On Flavonoids (Flavanols Flavonols Amentioning

confidence: 99%

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Polyphenol analysis using high‐resolution mass spectrometry allows differentiation of drought tolerant peanut genotypes

et al. 2019

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BACKGROUND Peanut (Arachis hypogaea L.) is an important economic food crop highly appreciated worldwide. Although peanut cultivation has been expanding to dry regions, with water stress during growth stages, current genotypes are not adapted to drought. This study aimed to identify and quantify the full range of polyphenols in five peanut genotypes with different degrees of drought tolerance developed by Embrapa (Brazil) using ultra‐high‐definition accurate‐mass liquid chromatography–electrospray ionization–LTQ‐Orbitrap–mass spectrometry. RESULTS Fifty‐eight polyphenols of the classes hydroxybenzoic acids, hydroxycinnamic acids, flavanols, flavonols and flavanones were identified and quantified using high mass accuracy data and confirmed by tandem mass spectrometric experiments. High‐definition mass spectrometric analyses revealed nine phenolic compounds that have never been reported in peanuts before. Polyphenol assessment using multivariate analysis allowed identification of the level of similarities among the five peanut genotypes studied. CONCLUSION Higher drought‐tolerant genotypes exhibited higher content of flavonoids, which suggests a relationship between these compounds and drought tolerance traits. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Section: Cluster Analyses Based On Flavonoids (Flavanols Flavonols Amentioning

confidence: 99%

Polyphenol analysis using high‐resolution mass spectrometry allows differentiation of drought tolerant peanut genotypes

et al. 2019

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“…In recent years, quercetin has become a rising concern in nutritional and therapeutic potential, owning to its multiple pharmacological effects (Russo, Spagnuolo, Tedesco, Bilotto, & Russo, ). In addition to antitumor, antiobesity, antihypertensive, and significant heart‐related benefits, a large number of in vivo studies have shown that quercetin had a strong potential for antidiabetes and its complications (Bule, Abdurahman, Nikfar, Abdollahi, & Amini, ; Hu et al, ; Lu et al, ; Marunaka et al, ; Patel et al, ; Shi et al, ; Y. Zhao et al, ; X. Zhu, Cheng, et al, ; Y. Zhu, Teng, et al, ). It has been found that quercetin prevents diabetes mellitus by decreasing blood glucose via enhancing insulin sensitivity and stimulating insulin secretion from β cells (Gaballah, Zakaria, Mwafy, Tahoon, & Ebeid, ; Jeong, Kang, Choi, Kim, & Kim, ).…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Yang

Cai

et al. 2019

Phytotherapy Research

185

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Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated. T2DM‐induced NAFLD and quercetin treatment models were established in vivo and in vitro. The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers. Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid (p = .0001) and the decreased liver total bile acid (p = .0005), quercetin could reduce lipid accumulation in the liver of db/db mice. Further mechanism studies showed that farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathways was involved in quercetin regulation of lipid metabolism in T2DM‐induced NAFLD. In high D‐glucose and free fatty acid cocultured HepG2 cells model, quercetin eliminated lipid droplets and restored the upregulated total cholesterol and triglyceride levels. Similar to the findings in mice, quercetin could also activate farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathway. These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.

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“…Quercetin has a bitter avor and is used as an ingredient in foods, beverages, and dietary supplements [14]. This compound has been reported to have pharmacological effects, such as anti-oxidant [15], anti-in ammatory [16,17], anti-virus [18], anti-diabetic effect [19]and anti-tumor activities [15,20,21]. However, the ExoS inhibitory effect of quercetin has not been reported.…”

mentioning

confidence: 99%

Quercetin attenuates the production of pro-inflammatory cytokines in H292 human lung epithelial cells infected with Pseudomonas aeruginosa, by modulating ExoS production

Ahn

Park

Jang

et al. 2020

Preprint

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Background: The type three secretion system (T3SS) is a major virulence system of Pseudomonas aeruginosa (P. aeruginosa). The effector protein Exotoxin S (ExoS) produced by P. aeruginosa is secreted into the host cells via the T3SS. For the purpose of screening the inhibitors with regard to ExoS secretion, we developed the sandwich-type enzyme-linked immunosorbent assay (ELISA) system. From the initial screening, quercetin was selected because it has the prominent effect of ExoS inhibition and also is known to have anti-inflammatory and antioxidant effects on mammalian cells.Results: In this study, we investigated the effects of quercetin on the expression and secretion of ExoS using the ELISA and Western blot analysis methods. The results showed that the secretion of ExoS was significantly decreased by 10, 20uM quercetin. Also, pscF and popD, which are composed of the T3SS needle, are reduced by quercetin at the mRNA level, and we confirmed the inhibitory effect of quercetin on cytokines in P. aeruginosa-infected H292 cells by real-time polymerase chain reaction (PCR). Conclusion: Collectively, quercetin inhibits the secretion of ExoS by reducing both ExoS production and the expression of the needle protein of T3SS. Furthermore, these results suggest that quercetin has the potential to be used as an anti-toxic treatment for the disease caused by P. aeruginosa infection.

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Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

Cited by 129 publications

References 61 publications

Polyphenol analysis using high‐resolution mass spectrometry allows differentiation of drought tolerant peanut genotypes

Polyphenol analysis using high‐resolution mass spectrometry allows differentiation of drought tolerant peanut genotypes

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Quercetin attenuates the production of pro-inflammatory cytokines in H292 human lung epithelial cells infected with Pseudomonas aeruginosa, by modulating ExoS production

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