Antidiabetic Effect of Seishin-kanro-to in KK-Ay Mice

Abstract

The hypoglycemic effect of Seishin-kanro-to (SK) was investigated in KK-Ay mice, one of the non-insulin dependent diabetic mellitus types. SK (1700 mg/kg) reduced the blood glucose of KK-Ay mice from 557 +/- 17 to 383 +/- 36 mg/100 ml 7 hours after single oral administration (P < 0.001). SK also decreased the blood glucose and improved glucose tolerance 5 weeks after repeated administration in KK-Ay mice. These results support, therefore, the use of SK in patients with diabetes and confirm its role as a traditional medicine. In addition, the active plants of SK were identified as the rhizome of Anemarrhena asphodeloides Bunge and the radix of Rehmannia glutinosa Liboschitz.

Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer

“…Radix Rehmanniae was described to have hypoglycemic effects from traditional practice of Chinese medicine, and was also observed from some other scientific research studies (Kiho et al, 1992;Miura et al, 1997). However, in this study, RR extract was only associated with a drop of plasma glucose at one time point after single treatment, probably due to the fact that time is required for the digestion and absorption of RR.…”

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

“…Indeed, studies have shown that SJH has hypoglycemic effects [21,48]. The water extract of Rehmannia glutinosa Libosch.…”

An in vivo Investigation on the Wound-Healing Effect of Two Medicinal Herbs Using an Animal Model with Foot Ulcer

“…In fact, RA has been used in inflammation control and prevention of insulin resistance [15,16] , and RR has been shown to elicit antihyperglycemic and anti-inflammatory effects [17][18][19][20][21] . However, the direct effects of RA and RR on diabetic foot ulcer have not been studied.…”