Antidiabetic Effect Test of Combination of Ginger (Zingiber officinale), Lemongrass (Cymbopogon citratus), and Cinnamon (Cinnamomum verum) on Male Mice (Mus musculus)

Abstract

Diabetes mellitus (DM) or diabetes is a disease caused by disorders related to the hormone insulin. Ginger, lemongrass and cinnamon are traditional plants that have the potential to be developed as herbal medicines. The combination of these traditional plants can be used as an alternative treatment for diabetes mellitus. Infusions of ginger, lemongrass and cinnamon contain secondary metabolites, namely flavonoids, terpenoids and tannins. These three active compounds have antioxidant, antidiabetic, and anti-inflammatory activities. The aim of this study was to determine the antidiabetic effect of the infusion of a combination of JSKM (ginger (Zingiber officinale), lemongrass (Cymbopogon citratus) and cinnamon (Cinnamomum verum)) on male mice (Mus Musculus). The design of this research is experimental with data analysis method using SPSS 16.0. Observation of healing time is done by observing the decrease in blood sugar levels for 7 days. In this study, 5 treatment groups were used, namely the negative control group (aquadest), the positive control group (glibenclamide), the P1 dose (162 mg/kgBW), the P2 dose (324 mg/kgBW), and the P3 dose (486 mg/kgBW). The most effective dose of the antidiabetic effect of JSKM infusion in male mice was in the P3 group with a dose of 486 mg mg/kgBW.

Effectivity Between Lemongrass Stew and Cinnamon Infusion in Reducing Blood Glucose Level in Diabetes Mellitus Patients

“…DM sufferers cannot produce enough insulin, or the body is unable to use insulin effectively resulting in excess glucose in the body (Susanti, 2019). Researchers argue that consuming cinnamon infusion once per day for 7 days is sufficient to lower blood glucose levels in DM patients, this is in accordance with Dewanti (2023) who says that consuming cinnamon infusion for 7 days influences reducing blood glucose levels. Researchers argue that cinnamon and lemon grass have the same effectiveness in lowering blood glucose levels when consumed regularly.…”

“…Evaluation of blood glucose levels after giving intervention is carried out after 7 days of administration which has decreased blood glucose levels blood. Like consuming lemongrass stew, cinnamon infusion can lower blood glucose levels for people with diabetes mellitus (Dewanti, 2023).…”