Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats

Antidiabetic Effects and Enzymatic Antioxidant Activity of Chicken Drumstick Mushroom (Coprinus comatus) Extract in Diabetic Rats Model

“…Previous studies have shown qualitative identification of the fruiting bodies of C. comatus ethyl acetate extract containing a moderate concentration of flavonoids compound (++), low levels of alkaloids (+), and saponins (+). 7 In the qualitative test of other studies, the mycelium extract of C. comatus using ethyl acetate solvent with a concentration of 100 parts per million (ppm) was identified to contain a strong concentration of flavonoids (+++), polyphenols (+++) and terpenoids (+). 2 The same results were also shown from the qualitative identification of the C. comatus ethanol extract of fruiting bodies containing moderate and low flavonoids (++) and saponins (+).…”

“…11 Additionally, saponins play a role in preventing excess glucose uptake in the intestinal mucosa to minimize catabolism by increasing the activity of adenosine monophosphate kinase (AMPK). 7 Another role is increasing insulin signalling to maintain consistent production and reduce blood glucose levels. Previous research has also shown that saponins reduce and minimize complications due to obesity and inflammation and alleviate liver necrosis, injury, and pain in insulin hormone-resistant rats while exhibiting signal transduction.…”

“…A previous study has also shown that the ethyl acetate extract of C. comatus at 250 mg doses can reduce blood glucose levels by 23.92% compared to the initial levels after 15 days of treatment using the extract. 7 In addition, the administration at a dose of 750 mg can reduce the level by 26.69%. 5 STZ induction in all treatment groups of rats not treated showed an increase of >230 mg/dL of fasting blood glucose levels after 14 days.…”

“…This needs to be conducted considering that DPP-4 plays a vital role in metabolism within the intestinal mucosa and affects the hormone GLP-1 as an insulinotropic. 7 Furthermore, ethyl acetate as a solvent in extracting fruit bodies of C. comatus and streptozotocin (STZ) induction to produce hyperglycemic rat permanent is still rare. Based on this, there is a need to determine the activity of the fruit body extract of C. comatus by using ethyl acetate solvent on Wistar rats (R. norvegicus) induced STZ.…”

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

“…The results confirmed this raw material as promising agents through key enzyme inhibition. Other mushrooms with antihyperglycaemic benefits are Coprinus comatus , since its ethyl acetate extract showed in vivo antidiabetic and antioxidant properties, an effect possible due to their composition in bioactive compounds (Husen et al ., 2021). Ethanolic extracts from H. erinaceus mycelium stood out by their potential myelin reparation in several neurodevelopmental disorders as demyelination.…”