Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice

Hua, Ping-Rang; Zhang, Guijun; Ren, Guixing

doi:10.1016/j.fct.2010.05.069

Cited by 88 publications

(44 citation statements)

References 34 publications

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“…[47] In another study, applying 100 mg/kg of cinnamon essential oil (containing cinnamaldehyde 78.51%) to KK-Ay mice resulted in a similar phenomenon during 35 days of investigation. [37] In an advanced study of chronic kidney disease associated with diabetes, Yan et al [48] found that 50 μM C. cassia bark extract, which contains sesquiterpenoids, has antidiabetic nephropathy activity.…”

Section: Antitumor and Anticancermentioning

confidence: 99%

“…[13] In previous publications, [14,36] linalool (50 mg/kg body weight) and citral (50 µg/mL) have also been confirmed to have essential contributions to inflammatory inhibition. According to Ping et al, [37] type-A procyanidin polyphenol (TAPP) isolated from C. zeylanicum bark plays a key role as an antiinflammatory agent when administered orally at a dose of 8 mg/kg body weight. Moreover, TAPP has been reported to inhibit LOX activity, leukotrienes synthesis, COX enzyme activity, and proinflammatory cytokines production (IL-1β and TNF-α).…”

Section: µG/mlmentioning

confidence: 99%

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Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

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Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antitumor, anticancer, antidiabetic, and anti-hypertriglyceridemia agent, mainly due to its phytochemical constituents such as phenolic and volatile compounds. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and by solvent extraction. The use of cinnamon in food and its ability to prevent oxidation and inhibit microbial growth are covered in this review. Its bioaccessibility, safety, and consumer acceptance are comprehensively discussed. This review also clearly shows a route to the use of cinnamon as an ingredient in functional foods. ARTICLE HISTORY

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Section: Antitumor and Anticancermentioning

confidence: 99%

Section: µG/mlmentioning

confidence: 99%

Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

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“…Hence, we aimed at designing and characterizing biologically acceptable novel cinnamon oil-based microemulsion system as drug delivery vehicle for azithromycin with minimum components in them. Cinnamon oil, chosen in this study, is known to possess diverse functions including analgesic, antiallergic, antidiabetic, antimicrobial, antioxidant, antipyretic, antispastic, antithrombotic, antiulcerogenic, anxiolytic, and antiulcerous effects (33)(34)(35)(36)(37)(38). Also, Cinnamomum zeylanicum has eugenol and transcinnamaldehyde as the major components in them (39).…”

Section: A R T I C L E C Lmentioning

confidence: 99%

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

2013

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Abstract. Azithromycin, an important member of the azalide subclass is effective against both Grampositive and Gram-negative organisms. Certain physicochemical properties of the drug like poor water solubility and relatively low bioavailability of 37% due to incomplete absorption after ingestion, aroused the need for the development of a novel drug delivery system to enhance the solubilization potential and antibacterial activity against Staphylococcus aureus at a very low concentration. Cinnamon oil (Cinnamonum zeylanicum)-based microemulsion system formulated using non-ionic surfactant, Tween 20, and water was characterized. The drug-incorporated system F4 (oil to surfactant ratio of 1:4 (v/v)) showed enhanced solubilization of the drug, droplet diameter of 5-8 nm, and a good thermodynamic stability. The effect of surfactant concentration exhibited a negative correlation with droplet size diameter and turbidity and a positive correlation with stability and viscosity. The system was investigated for its antibacterial activity that demonstrated a significantly higher activity at a minimum concentration (4 μg/ ml) of the novel drug-loaded system in comparison with the conventional formulation (128 μg/ml). Examination through scanning electron microscopy analysis further confirmed a considerable morphologic variation due to alteration in the membrane permeability of the microemulsion-treated system. The small droplet size of the microemulsion system and the antibacterial property of cinnamon oil, together, accounts clearly for the enhanced efficacy of the new formulated system F4 and not just azithromycin alone. Staining with acridine orange/ethidium bromide dyes as examined through fluorescence microscopy also substantiated with the results of membrane permeability of bacteria. Thus, our study discloses a potential oral drug delivery system of azithromycin with improved biocompatibility.

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“…It is showed that Cinnamon extracts (50, 100, 150 and 200 mg/kg) which include cinnamic acid significantly, decreased the blood glucose and lipid levels in mice 57 . Ping et al (2010) have studied the hypoglycemic effect of cinnamon oil which contains water soluble polyphenol type A polymer, cinnemaldehyde and cinnamic acid as active com-pounds, in type 2 diabetic animal model 58 . They found that fasting blood glucose concentration was significantly decreased with the 100 mg/kg group compared to other groups.…”

Section: Cinnamic Acidmentioning

confidence: 99%

Beneficial effects of commonly used phytochemicals in diabetes mellitus

Bacanlı¹,

Göktaş²,

Başaran³

et al. 2016

actapharm

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Diabetes mellitus, a metabolic disorder, is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycemia. The prevalence of diabetes is increasing worldwide, especially in developing countries. The diabetes treatment has higher costs, limited efficacy and side effects. As a result of these factors, patients often have used alternative forms of therapy such as herbal medicines. Plants often contain various amounts of phenolics, flavonoids and tannins and most of the studies are focused on the antidiabetic effects of these phytochemicals due to their antioxidant properties. In this review, the role of oxidative stress on diabetes and the effects of different phytochemicals (limonene, sinnamic acid and ursolic acid) to diabetes mellitus therapy will be discussed.

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Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice

Cited by 88 publications

References 34 publications

Cinnamon and its derivatives as potential ingredient in functional food—A review

Cinnamon and its derivatives as potential ingredient in functional food—A review

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

Beneficial effects of commonly used phytochemicals in diabetes mellitus

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